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Durvalumab-induced thyroiditis in a patient with non-small cell lung carcinoma: a case report and review of pathogenic mechanisms
BackgroundImmune checkpoint inhibitors (ICI) targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 and its...
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Association between the single-nucleotide polymorphism (rs1030868) variant in matrix metallopeptidase 2 gene and the development of lymphedema
BackgroundUnderstanding the genetic and molecular pathophysiology of lymphedema contributes to the identification of the complex interaction of genes...
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Inflammatory human leucocyte antigen genotypes are not a risk factor in chronic subdural hematoma development
BackgroundChronic subdural hematoma (CSDH) pathophysiology has undergone a paradigm shift from being regarded as solely traumatic to be driven mainly...
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Large-scale integrative analysis of juvenile idiopathic arthritis for new insight into its pathogenesis
BackgroundJuvenile idiopathic arthritis (JIA) is one of the most prevalent rheumatic disorders in children and is classified as an autoimmune disease...
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DON in pediatric cerebral malaria, a phase I/IIA dose-escalation safety study: study protocol for a clinical trial
BackgroundDespite treatment with highly effective antimalarial drugs, malaria annually claims the lives of over half a million children under 5-years...
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Adaptive immune receptor features related to breast cancer tissue in Kenyan patients: high immunoglobulin gene expression and high levels of gamma-delta T-cells
BackgroundCharacterization of the breast cancer (BC) immune response may provide information for a point of intervention, such as application of...
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Prevalence and risk factors of antibodies towards HLA Class I and Class II in Malaysian renal transplant candidates
Antibody-mediatedrejection (AMR) still persists as the major hurdle towards successful renal allograft survival. This paper aims to report on the...
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Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system
BackgroundPost-acute sequelae of COVID-19 (PASC), also now known as long COVID, has become a major global health and economic burden. Previously, we...
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Differential Levels of mRNAs in Normal B Lymphocytes, Monoclonal B Lymphocytosis and Chronic Lymphocytic Leukemia Cells from the Same Family Identify Susceptibility Genes
IntroductionPeople with a family history of chronic lymphocytic leukemia (F-CLL) have an increased risk of monoclonal B lymphocytosis (F-MBL), which...
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The Evolving Landscape of Cutaneous Sarcoidosis: Pathogenic Insight, Clinical Challenges, and New Frontiers in Therapy
Sarcoidosis is a multisystem disorder of unknown etiology characterized by accumulation of granulomas in affected tissue. Cutaneous manifestations...
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An immunogenetic perspective of ANCA-associated vasculitides
BackgroundAnti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are a group of small vessel vasculitides characterized by...
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Frequency of HLA alleles and KIR Ligands in Acute Myeloid Leukemia in Indian Cohort
Relationship between various combinations of KIR ligands and HLA alleles have been studied in several diseases. The aim of this retrospective study...
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Oral Psoriasis—An Overlooked Entity: Current Paradigms and Future Perspectives
Purpose of ReviewPsoriasis is a chronic, genetically determined, scaly, and inflammatory disease of the skin. Pathogenesis is multi-factorial,...
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Clinical evaluation of droplet digital pcr for suspected ascites infection in patients with liver cirrhosis
BackgroundDroplet digital PCR (ddPCR) is increasingly used in diagnosing clinical pathogens, but its effectiveness in cirrhosis patients with...
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The pediatric common variable immunodeficiency — from genetics to therapy: a review
Common variable immunodeficiency (CVID) is the most prevalent antibody deficiency, characterized by remarkable genetic, immunological, and clinical...
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Implication of single nucleotide polymorphisms in Interleukin-10 gene (rs1800896 and rs1800872) with severity of COVID-19
BackgroundCoronavirus disease 2019 (COVID-19) is an ongoing pandemic which has emerged as a new challenge for the medical sciences. Severity of...
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Audit of donor centre: guidelines by the World Marrow Donor Association Quality and Regulation Working Group
According to the Standards of the World Marrow Donor Association (WMDA) 2020 [1] unrelated stem cell donor registries are responsible for compliance...
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First-line disease modifying treatments in pediatric-onset multiple sclerosis in Greece: therapy initiation at more advanced age is the main cause of treatment failure, in a retrospective observational study, with a cohort from a single Multiple Sclerosis Center
ObjectivesLong-term immunomodulatory therapy of pediatric onset-multiple sclerosis (POMS) is based mainly on published case series and...
