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Down-regulation of platelet adhesion receptors is a controlling mechanism of thrombosis, while also affecting post-transfusion efficacy of stored platelets
Physiologically, upon platelet activation, uncontrolled propagation of thrombosis is prevented by regulating mechanisms which affect the expression...
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Conservative Hypomethylation of Mesenchymal Stem Cells and Their Secretome Restored the Follicular Development in Cisplatin-Induced Premature Ovarian Failure Mice
Premature ovarian failure (POF) is one of the main causes of infertility in women under the age of 40 years. Recently , epigenetic reprogramming,...
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Anti-inflammatory and antioxidant efficacy of lavender oil in experimentally induced thrombosis
BackgroundLavender oil (LO) possesses anti-inflammatory, antioxidant, antifungal, antibacterial, sedative, cardio-protective, and antinociceptive...
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SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism
Evidence suggests that platelets may directly interact with SARS-CoV-2, raising the concern whether ACE2 receptor plays a role in this interaction....
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Fruitflow inhibits platelet function by suppressing Akt/GSK3β, Syk/PLCγ2 and p38 MAPK phosphorylation in collagen-stimulated platelets
BackgroundPlatelets play an important role in the progression of atherosclerosis and cardiovascular events. The inhibition of platelet function is a...
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Sodium bicarbonate as a local adjunctive agent for limiting platelet activation, aggregation, and adhesion within cardiovascular therapeutic devices
Cardiovascular therapeutic devices (CTDs) remain limited by thrombotic adverse events. Current antithrombotic agents limit thrombosis partially,...
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RASopathies and hemostatic abnormalities: key role of platelet dysfunction
BackgroundBleeding anomalies have been reported in patients affected by Noonan syndrome. No study has been performed in patients with molecularly...
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P2Y12-dependent activation of hematopoietic stem and progenitor cells promotes emergency hematopoiesis after myocardial infarction
Emergency hematopoiesis is the driving force of the inflammatory response to myocardial infarction (MI). Increased proliferation of hematopoietic...
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Thrombo-inflammation in acute ischaemic stroke — implications for treatment
Ischaemic stroke elicits a strong neuroinflammatory response, but the functional relevance and therapeutic potential of neuroinflammation has only...
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Platelets in pediatric and neonatal sepsis: novel mediators of the inflammatory cascade
AbstractSepsis, a dysregulated host response to infection, has been difficult to accurately define in children. Despite a higher incidence,...
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Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury
BackgroundThe essential roles of platelets in thrombosis have been well recognized. Unexpectedly, thrombosis is prevalent during thrombocytopenia...
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Poly (ADP-ribose) Polymerase-1 modulations in the genesis of thrombosis
Thrombosis, a coagulation disorder, occurs due to altered levels of coagulation, fibrinolytic and immune factors, which are otherwise known to...
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Lipoxin A4 analogue, BML-111, reduces platelet activation and protects from thrombosis
Formyl peptide receptors (FPRs) are members of seven transmembrane G protein-coupled receptors superfamily that exhibit different responses based on...
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The effects of tranexamic acid on platelets in patients undergoing cardiac surgery: a systematic review and meta-analysis
AbstractThis meta-analysis was designed to evaluate the effects of tranexamic acid (TXA) on platelets in patients undergoing cardiac surgery (CS)....
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Modifying strategies for SDF-1/CXCR4 interaction during mesenchymal stem cell transplantation
Mesenchymal stem cell (MSC) transplantation is regarded as a promising candidate for the treatment of ischaemic heart disease. The major hurdles for...
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SLA2 is a prognostic marker in HNSCC and correlates with immune cell infiltration in the tumor microenvironment
PurposeTo investigate Src-like adaptor 2 gene ( SLA2 ) expression in head and neck squamous cell carcinoma (HNSCC), its potential prognostic value,...
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Oseltamivir as rescue therapy for persistent, chronic, or refractory immune thrombocytopenia: a case series and review of the literature
Immune thrombocytopenia (ITP) is an autoimmune disease that results from antibody-mediated platelet destruction and impaired platelet production....
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Bioactive potential of natural biomaterials: identification, retention and assessment of biological properties
Biomaterials have had an increasingly important role in recent decades, in biomedical device design and the development of tissue engineering...
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C-type lectin-like receptor 2: roles and drug target
C-type lectin-like receptor-2 (CLEC-2) is a member of the C-type lectin superfamily of cell surface receptors. The first confirmed endogenous and...
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