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Hypoprolactinemia. Does it matter? Redefining the hypopituitarism and return from a mumpsimus
Prolactin (PRL) is secreted by the lactotroph cells in the anterior pituitary gland which is under inhibitory control of dopamine. The mature human...
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Toxic interactions between dopamine, α-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson’s disease
Parkinson’s disease is characterized by its distinct pathological features; loss of dopamine neurons in the substantia nigra pars compacta and...
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A phase I trial of caffeine to evaluate safety in infants with hypoxic-ischemic encephalopathy
ObjectiveCaffeine provides neuroprotection following hypoxic-ischemic injury in animals. We characterized the safety of escalating doses of caffeine...
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Therapeutic hypothermia modulates the neurogenic response of the newborn piglet subventricular zone after hypoxia-ischemia
BackgroundNeuroprotection combined with neuroregeneration may be critical for optimizing functional recovery in neonatal encephalopathy. To...
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The effect of cinnamic acid on fetal hippocampus in pregnant rats
Uteroplacental insufficiency (UPI) causes neurodevelopmental deficits in the brain of intrauterine growth-restricted offspring, even though the...
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Neuroprotective therapies in the NICU in term infants: present and future
AbstractOutcomes of neonatal encephalopathy (NE) have improved since the widespread implementation of therapeutic hypothermia (TH) in high-resource...
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Fetal brain damage in congenital hydrocephalus
BackgroundCongenital hydrocephalus (HCP) is a developmental brain disorder characterized by the abnormal accumulation of cerebrospinal fluid within...
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Clinical practice guidelines for the antenatal management of dichorionic diamniotic twin pregnancies: a systematic review
ObjectiveThis review aimed to identify guidelines with recommendations applicable to the antenatal management of dichorionic diamniotic twin...
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Anti-infectious and anti-inflammatory effect of amniopatch in the treatment of spontaneous previable rupture of membranes
Spontaneous previable rupture of membranes complicates approximately 0.4–0.7% of pregnancies and is associated with severe maternal and neonatal...
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Delayed interval delivery in a quadruplet pregnancy: a case report and literature review
BackgroundAs the rate of multiple pregnancies increases, delayed interval delivery (DID) is increasingly being implemented to improve perinatal...
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Melatonin 1A and 1B Receptors’ Expression Decreases in the Placenta of Women with Fetal Growth Restriction
Melatonin and its metabolites prevent oxidative stress and apoptosis, and it is actively produced by the placenta during pregnancy. Melatonin 1A and...
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Rudimentary horn pregnancy, a differential diagnosis of an intraabdominal pregnancy: a case report
BackgroundRudimentary horn pregnancy is a rare life-threatening obstetric condition with clinical and sonographic presentation resembling that of an...
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Lithium rescues cultured rat metatarsals from dexamethasone-induced growth failure
BackgroundGlucocorticoids are commonly used in children with different chronic diseases. Growth failure represents a so far untreatable undesired...
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Repurposing azithromycin for neonatal neuroprotection
BackgroundInflammation contributes to neonatal hypoxic–ischemic brain injury pathogenesis. We evaluated the neuroprotective efficacy of azithromycin,...
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Emergency cervical cerclage in delayed-interval delivery of twin pregnancies: a sco** review
BackgroundThe protocol for delayed-interval delivery of the second twin in twin pregnancies has not been standardized. Cervical cerclage is often...
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Neuroprotective therapies in the NICU in preterm infants: present and future (Neonatal Neurocritical Care Series)
AbstractThe survival of preterm infants has steadily improved thanks to advances in perinatal and neonatal intensive clinical care. The focus is now...
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Time to regain birthweight and association with neurodevelopmental outcomes among extremely preterm newborns
ObjectiveDetermine association between time to regain birthweight and 2-year neurodevelopment among extremely preterm (EP) newborns.
Study design ...
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Postnatal cerebral hemodynamics in infants with severe congenital heart disease: a sco** review
AbstractPatients with severe congenital heart disease (CHD) are at risk for impaired neurodevelopment. Cerebral blood supply may be diminished by...
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Maternal and neonatal outcomes following magnesium sulfate in the setting of chorioamnionitis: a meta-analysis
PurposeMagnesium sulfate (MgSO 4 ) has been widely used in obstetrics as a mean to help decrease maternal and neonatal morbidity in various antenatal...
