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Expert Consensus on the Use of the PRESERFLO™ MicroShunt Device in the Treatment of Glaucoma: A Modified Delphi Panel
IntroductionThe implantation of the PRESERFLO™ MicroShunt (PMS) device has been shown to significantly lower increased intraocular pressure (IOP) in...
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Women in a situation of homelessness and violence: a single-case study using the photo-elicitation technique
BackgroundViolence against women places them in a vulnerable position with regard to homelessness. Although sometimes invisible, women’s homelessness...
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Use of Systemic Therapies for Treatment of Psoriasis in Patients with a History of Treated Solid Tumours: Inference-Based Guidance from a Multidisciplinary Expert Panel
BackgroundPatients with treated solid tumours (TSTs) are a highly heterogeneous population at an increased risk for malignancy compared with the...
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The elicitation of patient and physician preferences for calculating consumer-based composite measures on hospital report cards: results of two discrete choice experiments
PurposeThe calculation of aggregated composite measures is a widely used strategy to reduce the amount of data on hospital report cards. Therefore,...
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Expert consensus on the management of infusion-related reactions (IRRs) in patients with sickle cell disease (SCD) receiving crizanlizumab: a RAND/UCLA modified Delphi panel
Crizanlizumab, a monoclonal antibody against P-selectin, has been shown to reduce vaso-occlusive crises (VOCs) compared to placebo in patients ≥ 16...
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Rewiring care delivery through Digital Therapeutics (DTx): a machine learning-enhanced assessment and development (M-LEAD) framework
BackgroundDigital transformation has sparked profound change in the healthcare sector through the development of innovative digital technologies....
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Comprehensive Review of Methods to Assess Uncertainty in Health Economic Evaluations
Uncertainty assessment is a cornerstone in model-based health economic evaluations (HEEs) that inform reimbursement decisions. No comprehensive...
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Trust me; I know what I am doing investigating the effect of choice list elicitation and domain-relevant training on preference reversals in decision making for others
One core assumption of standard economic theory is that an individual’s preferences are stable, irrespective of the method used to elicit them. This...
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A Qualitative Study to Develop and Evaluate the Content Validity of the Vitiligo Patient Priority Outcome (ViPPO) Measures
IntroductionVitiligo can be associated with a psychological burden, stigmatization and impaired quality of life. Tools to assess the impact of...
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Including Young Children in the Development and Testing of Patient Reported Outcome (PRO) Instruments: A Sco** Review of Children’s Involvement and Qualitative Methods
BackgroundQualitative research during the development/testing of Patient Reported Outcome Measures (PROMs) is recommended to support content...
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Develo** a Natural History Model for Duchenne Muscular Dystrophy
BackgroundThe aim of this study was to pool multiple data sets to build a patient-centric, data-informed, natural history model (NHM) for Duchenne...
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Development and psychometric validation of a patient-reported outcome measure of recurrent urinary tract infection impact: the Recurrent UTI Impact Questionnaire
PurposeRecurrent urinary tract infection (rUTI) is a highly prevalent condition associated with significant poor quality of life outcomes. A...
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Local Level Economic Evaluation: What is it? What is its Value? Is it Sustainable?
In Australia, local health services with allocated budgets manage public hospital services for defined geographical areas. The authors were embedded...
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Assessing the patient experience of respiratory syncytial virus infection: development of a patient-reported outcome measure
BackgroundRespiratory syncytial virus (RSV) causes significant morbidity and mortality in older adults. Despite a number of RSV vaccine candidates in...
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Integrating expert opinions with clinical trial data to analyse low-powered subgroup analyses: a Bayesian analysis of the VeRDiCT trial
BackgroundTypically, subgroup analyses in clinical trials are conducted by comparing the intervention effect in each subgroup by means of an...
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Development of the Cutaneous Dermatomyositis Investigator Global Assessment (CDM-IGA): A De Novo IGA of Cutaneous Manifestations of Dermatomyositis
IntroductionDermatomyositis (DM) is a rare systemic autoimmune disease characterized by a distinctive debilitating skin rash and skeletal muscle...
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Incremental cost and health gains of the 2016 WHO antenatal care recommendations for Rwanda: results from expert elicitation
ObjectivesHigh-quality evidence of effectiveness and cost-effectiveness is rarely available and relevant for health policy decisions in low-resource...
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Development of Novel Patient-Reported Outcome (PRO) and Observer-Reported Outcome (ObsRO) Instruments in Retinitis Pigmentosa (RP) and Leber Congenital Amaurosis (LCA): ViSIO-PRO and ViSIO-ObsRO
IntroductionRetinitis pigmentosa (RP) and Leber congenital amaurosis (LCA) are rare inherited retinal degenerative disorders resulting in visual...
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Use of Systemic Therapies for Treatment of Psoriasis in People Living with Controlled HIV: Inference-Based Guidance from a Multidisciplinary Expert Panel
BackgroundPeople living with human immunodeficiency virus (PLHIV) have a similar prevalence of psoriasis as the general population, though incidence...