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Family dissolution and children’s social well-being at school: a historic cohort study
BackgroundFamily dissolution has become more common and one third of the child population in most Western countries now experience family...
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Development and characterization of solid dispersion-based orodispersible tablets of cilnidipine
BackgroundCilnidipine, a calcium channel blocker, is the first-line drug for hypertension and belongs to Biopharmaceutics Classification System II....
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Dose-dependent bioavailability, absorption-rate limited elimination, and tissue distribution of the ATR inhibitor BAY-1895344 (elimusertib) in mice
PurposeAtaxia Telangiectasia and Rad3-related (ATR) is a pivotal component of the DNA damage response and repair pathways that is activated in...
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Characterization and pharmacokinetics of cinnamon and star anise compound essential oil pellets prepared via centrifugal granulation technology
Cinnamon and star anise essential oils are extracted from natural plants and provide a theoretical basis for the development and clinical application...
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Solubility enhancing lipid-based vehicles for artemether and lumefantrine destined for the possible treatment of induced malaria and inflammation: in vitro and in vivo evaluations
BackgroundThe lipid self-emulsifying system has been advanced as a promising delivery vehicle for improving the solubility and bioavailability of...
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PGT-A is associated with reduced cumulative live birth rate in first reported IVF stimulation cycles age ≤ 40: an analysis of 133,494 autologous cycles reported to SART CORS
PurposeTo evaluate the impact of preimplantation genetic testing for aneuploidy (PGT-A) on cumulative live birth rate (CLBR) in IVF cycles.
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Preparation, optimization, and characterization of genistein-ginseng long-acting polymeric gel as a breast cancer treatment alternative
To address the prevalent genistein (GST) metabolism and inadequate intestinal absorption, an oral long-acting and gastric in-situ gelling gel was...
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Solid self-nanoemulsifying drug delivery systems of nimodipine: development and evaluation
BackgroundThis study aimed to formulate solid self-nanoemulsifying drug delivery systems (SNEDDS) for nimodipine (NIM). The selection of Cremophor RH...
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Modified medication use in dysphagia: the effect of thickener on drug bioavailability—a systematic review
IntroductionDysphagia is associated with long-term conditions including strokes, dementia, Parkinson’s disease and frailty. Dysphagia affects 30–40%...
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Application of Box–Behnken design and desirability function in the development and optimization of self-nanoemulsifying drug delivery system for enhanced dissolution of ezetimibe
BackgroundThis study is focused on develo** and optimizing a self-nanoemulsifying drug delivery system (SNEDDS) of BCS class II drug (ezetimibe)...
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Lymph node retrieval after colorectal cancer surgery: a comparative study of the efficacy between the conventional manual method and a new fat dissolution method
PurposeThis study compared the efficacy of two different methods for lymph node (LN) searching after colorectal cancer surgery: the fat dissolution...
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Exploring the evolution of engagement between academic public health researchers and decision-makers: from initiation to dissolution
ContextRelationships between researchers and decision-makers have demonstrated positive potential to influence research, policy and practice. Over...
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Unique Psychological Mechanisms Underlying Psilocybin Therapy Versus Escitalopram Treatment in the Treatment of Major Depressive Disorder
The mechanisms by which Psilocybin Therapy (PT) improves depression remain an important object of study, with scientists actively exploring acute...
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Dose-response relationships of LSD-induced subjective experiences in humans
Lysergic acid diethylamide (LSD) is a potent classic serotonergic psychedelic, which facilitates a variety of altered states of consciousness. Here...
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Static and Dynamic Filler-Associated Tear Trough Deformities: Manifestations and Treatment Algorithm
BackgroundFillers are popular substances for the correction of tear trough deformity. Despite well-documented complications increasing gradually,...
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Dystrophic calcinosis: structural and morphological composition, and evaluation of ethylenediaminetetraacetic acid (‘EDTA’) for potential local treatment
BackgroundTo perform a detailed morphological analysis of the inorganic portion of two different clinical presentations of calcium-based deposits...
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Evaluation of a dry therapeutic urinary diet and concurrent administration of antimicrobials for struvite cystolith dissolution in dogs
BackgroundStruvite urolithiasis with bacterial urinary tract infection (UTI) is commonly reported in dogs; few data exist to describe successful...
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Interpreting the efficacy enhancement mechanism of Chinese medicine processing from a biopharmaceutic perspective
Chinese medicine processing (CMP) is a unique pharmaceutical technology that distinguishes it from natural medicines. Current research primarily...
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Preparation, characterization and evaluation of fenofibrate: benzoic acid cocrystals with enhanced pharmaceutical properties
BackgroundCocrystallization process involved the understanding of interaction at molecular level between two molecules in context to their crystal...
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Bioavailability of Cariban® Capsules: A Modified-Release Fixed-Dose Combination of Doxylamine and Pyridoxine to Relieve Nausea and Vomiting During Pregnancy
BackgroundNausea and vomiting is a very prevalent condition during pregnancy. Combination of doxylamine and pyridoxine is placed as first-line...
