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Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major public health burden worldwide. The most common form of NCD is...
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Chronic myeloid leukemia stem cells
Chronic myeloid leukemia (CML) is caused by BCRABL1 in a cell with the biological potential, intrinsic or acquired, to cause leukemia. This cell is...
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Controlled drug delivery vehicles for cancer treatment and their performance
Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose...
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Inflammation and tumor progression: signaling pathways and targeted intervention
Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses tumor progression, potentially...
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Review on antioxidants and evaluation procedures
Antioxidants are the substances that are capable of counteracting the damaging effects of the physiological process of oxidation occur in animal...
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Cysteinyl-glycine reduces mucosal proinflammatory cytokine response to fMLP in a parenterally-fed piglet model
Background:PepT1 transports dietary and bacterial peptides in the gut. We hypothesized that cysteinyl-glycine would ameliorate the inflammatory...
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Nod2–Rip2 Signaling Contributes to Intestinal Injury Induced by Muramyl Dipeptide Via Oligopeptide Transporter in Rats
Background and AimsPepT1 can transport bacterial oligopeptide products and induce intestinal inflammation. Our aim was to investigate the mechanism...
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Site-Specifically Labeled Immunoconjugates for Molecular Imaging—Part 1: Cysteine Residues and Glycans
Due to their remarkable selectivity and specificity for cancer biomarkers, immunoconjugates have emerged as extremely promising vectors for the...
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An insight into the potentially old-wonder molecule—quercetin: the perspectives in foresee
Use of phyto-medicine and digitalization of phyto-compounds has been fallen enthralling field of science in recent years. Quercetin, a flavonoid with...