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Effect of co-trimoxazole and N-acetylcysteine alone and in combination on bacterial adherence on ureteral stent surface
To assess the effect of co-trimoxazole and N-acetylcysteine (NAC), alone and in combination, on bacterial adherence to biofilm formed on ureteral...
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The Evaluation of Mass/DNA Copy Number of Mitochondria in Umbilical Cord Blood-derived Hematopoietic Stem Cells Cocultured with MSCs
Over recent decades, UCB has been widely used as an excellent alternative source of HSCs for treating many hematologic disorders. Recent studies...
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A case series of co-infection in Mycobacterium tuberculosis and other pathogens: insights from nanopore sequencing
BackgroundTuberculosis (TB) continues to be a major global health burden, and co-infection with other pathogens further complicates the diagnosis and...
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Respiratory co-infections in COVID-19-positive patients
BackgroundOpportunistic respiratory infections may complicate critically ill patients with COVID-19. Early detection of co-infections helps to...
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In vitro CAR-T cell killing: validation of the potency assay
For advanced therapy medicinal products, the development and validation of potency assays are required, in accordance with international guidelines,...
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Granulocyte macrophage colony-stimulating factor-induced macrophages of individuals with autism spectrum disorder adversely affect neuronal dendrites through the secretion of pro-inflammatory cytokines
BackgroundA growing body of evidence suggests that immune dysfunction and inflammation in the peripheral tissues as well as the central nervous...
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Colonic TRPV4 overexpression is related to constipation severity
BackgroundChronic constipation is prevalent and involves both colon sensitivity and various changes in intestinal bacteria, particularly...
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Rescue in vitro maturation using ovarian support cells of human oocytes from conventional stimulation cycles yields oocytes with improved nuclear maturation and transcriptomic resemblance to in vivo matured oocytes
PurposeDetermine if the gene expression profiles of ovarian support cells (OSCs) and cumulus-free oocytes are bidirectionally influenced by...
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Cervical carcinoma induces NLRP3 inflammasome activation and IL-1ß release in human peripheral blood monocytes affecting patients’ overall survival
PurposeOur group previously demonstrated that genetic variants in inflammasome genes contribute to protection against the establishment of human...
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COVID-19 bacteremic co-infection is a major risk factor for mortality, ICU admission, and mechanical ventilation
BackgroundRecent single-center reports have suggested that community-acquired bacteremic co-infection in the context of Coronavirus disease 2019...
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Human Hematopoietic Stem Cells Co-cultured in 3D with Stromal Support to Optimize Lentiviral Vector-mediated Gene Transduction
HSC transplantation (HSCT) has emerged as a promising treatment option for hematological and immunological disorders. Unfortunately, many viral...
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Development of two multiplex PCR assays for rapid detection of eleven Gram-negative bacteria in children with septicemia
AimThis study aimed to develop a multiplex PCR assay for simultaneous detection of major Gram-negative etiologies of septicemia and evaluate its...
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Identification and validation of tumor-specific T cell receptors from tumor infiltrating lymphocytes using tumor organoid co-cultures
T cell receptor-engineered T cells (TCR-Ts) therapy is promising for cancer immunotherapy. Most studies have focused on identifying tumor-specific T...
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The expression analysis of SerpinB9 in hepatoblastoma microenvironment
PurposeIn this research, we analyzed the expression of serpinB9 in hepatoblastoma and investigated the factors which enhance its expression.
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IL-25 induces airway remodeling in asthma by orchestrating the phenotypic changes of epithelial cell and fibrocyte
BackgroundPrevious studies have shown that IL-25 levels are increased in patients with asthma with fixed airflow limitation (FAL). However, the...
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Reduced regulatory effects of bone marrow-derived mesenchymal stem cells on activated T lymphocytes and Th1/Th2 cytokine secretion in children with aplastic anemia
Acquired aplastic anemia (AA) is a recognized immune-mediated disorder and abnormally activated T lymphocyte-mediated bone marrow destruction is...
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M2-type tumor-associated macrophages upregulated PD-L1 expression in cervical cancer via the PI3K/AKT pathway
Background and purposePD-1/PD-L1 inhibitors have become a promising therapy. However, the response rate is lower than 30% in patients with cervical...
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Hepatic recruitment of myeloid-derived suppressor cells upon liver injury promotes both liver regeneration and fibrosis
BackgroundThe liver regeneration is a highly complicated process depending on the close cooperations between the hepatocytes and non-parenchymal...
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The effect of PD-1/PD-L1 signaling axis on the interaction between CD19+B cells and CD4+T cells in peripheral blood of patients with systemic lupus erythematosus
BackgroundThe defect of B cell self-tolerance and the continuous antigen presentation by T cells (TCs) mediated by autoreactive B cells (BCs) play a...
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IL-6-induced response of human osteoblasts from patients with rheumatoid arthritis after inhibition of the signaling pathway
Interleukin (IL-) 6 is a critical factor in inflammatory processes of rheumatoid arthritis (RA). This is of high interest as the progression of RA...
