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Understanding caregiver descriptions of initial signs and symptoms to improve diagnosis of metachromatic leukodystrophy
BackgroundMetachromatic leukodystrophy (MLD), a relentlessly progressive and ultimately fatal condition, is a rare autosomal recessive lysosomal...
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Development and Psychometric Validation of a Patient-Reported Outcome Measure to Assess the Signs and Symptoms of Chronic Hand Eczema: The Hand Eczema Symptom Diary (HESD)
IntroductionChronic Hand Eczema (CHE) is an inflammatory skin disease of the hands. The Hand Eczema Symptom Diary (HESD) is a new patient-reported...
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The lack of correlation between symptoms and signs in patients with meibomian gland dysfunction: a secondary analysis of the multicenter, randomized controlled trial
BackgroundThis study was performed to investigate the association between symptoms and signs in patients with meibomian gland dysfunction (MGD).
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Awareness of colorectal cancer signs and symptoms: a national cross-sectional study from Palestine
BackgroundIn low-resource settings, the awareness level of colorectal cancer (CRC) signs and symptoms plays a crucial role in early detection and...
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Diagnostic prediction of gastrointestinal graft-versus-host disease based on a clinical- CT- signs nomogram model
ObjectiveGastrointestinal graft-versus-host disease (GI-GVHD) is one of the complications that can easily occur after hematopoietic stem cell...
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The effects of probiotics supplements on metabolic indices and clinical signs in patients with diabetic retinopathy, a randomized double blind clinical trial
PurposeThis study was carried out to evaluate the effects of probiotics administration on clinical status and metabolic profiles in diabetic...
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Selected autonomic signs and symptoms as risk markers for phenoconversion and functional dependence in prodromal Parkinson’s disease
PurposeTo determine whether dysautonomia can stratify individuals with other prodromal markers of Parkinson’s disease (PD) for risk of...
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Primary healthcare professionals’ perspectives on patient help-seeking for lung cancer warning signs and symptoms: a qualitative study
BackgroundLung cancer is the leading cause of cancer incidence and mortality worldwide. Prompt patient help-seeking for signs and symptoms suggestive...
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Neurological signs, symptoms and MRI abnormalities in patients with congenital melanocytic naevi and evaluation of routine MRI-screening: systematic review and meta-analysis
BackgroundA congenital melanocytic naevus (CMN) is a rare skin condition that can be associated with abnormalities of the central nervous system...
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A new classification of lumbar Basstrup’s disease based on radiographic and clinical symptoms
ObjectiveTo propose a new classification method for lumbar Basstrup’s disease based on radiographic and clinical symptoms, and to test its...
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Symptoms and signs of conjunctivitis as predictors of disease course in COVID-19 syndrome
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can induce conjunctivitis signs and symptoms. However, limited information is...
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Significance of clinical symptoms and red flags in early differential diagnosis of Parkinson’s disease and atypical Parkinsonian syndromes
The clinical presentation of Parkinson’s disease and atypical Parkinsonian syndromes is often heterogeneous. Additional diagnostic procedures...
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Musculoskeletal pain and muscular weakness as the main symptoms of adult hypophosphatasia in a Spanish cohort: clinical characterization and identification of a new ALPL gene variant
IntroductionHypophosphatasia (HPP) is a rare inherited disorder, caused by mutations in the alkaline phosphatase ( ALPL) gene, which encodes for the...
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Effectiveness of a New Active Tear Substitute Containing 0.2% Hyaluronic Acid and 0.001% Hydrocortisone on Signs and Symptoms of Dry Eye Disease by Means of Low- and High-Tech Assessments
IntroductionAn innovative eye drops formulation containing 0.2% hyaluronic acid and a low concentration of hydrocortisone (0.001%; hereafter HALH)...
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Public knowledge of risk factors and warning signs of heart attack and stroke
BackgroundKnowledge of the predisposing risk factors and prompt recognition of the warning signs for heart attack and stroke is fundamental in...
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Detecting subtle signs of depression with automated speech analysis in a non-clinical sample
BackgroundAutomated speech analysis has gained increasing attention to help diagnosing depression. Most previous studies, however, focused on...
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Clinical features of acute attacks, chronic symptoms, and long-term complications among patients with acute hepatic porphyria in Japan: a real-world claims database study
BackgroundAcute hepatic porphyria (AHP) is a family of rare genetic diseases, including acute intermittent porphyria, variegate porphyria, hereditary...
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Levoketoconazole improves clinical signs and symptoms and patient-reported outcomes in patients with Cushing’s syndrome
PurposeThe efficacy of levoketoconazole in treating hypercortisolism was demonstrated in an open-label phase 3 study (SONICS) of adults with...
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Dry eye signs and symptoms in patients on aromatase inhibitor therapy
PurposeThe study aimed to test whether symptomatic dry eye in aromatase inhibitor (AI) patients is associated with the clinical features of...
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Psychometric evaluation of the Symptoms of Infection with Coronavirus-19 (SIC): results from a cross-sectional study and a phase 3 clinical trial
BackgroundThe Symptoms of Infection with Coronavirus-19 (SIC) is a 30-item patient-reported outcome (PRO) measure scored by body system composites to...
