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  1. Deciphering glutamine metabolism patterns for malignancy and tumor microenvironment in clear cell renal cell carcinoma

    Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer characterized by metabolic reprogramming. Glutamine metabolism is...

    Gengrun Wu, Teng Li, ... Hailiang Zhang in Clinical and Experimental Medicine
    Article Open access 06 July 2024
  2. LncRNA LBX2-AS1 promotes proliferation and migratory capacity of clear cell renal cell carcinoma through mitophagy

    Background

    Long non-coding RNAs (lncRNAs) have been extensively investigated in the field of cancer, among which, lncRNA ladybird homeobox 2-antisense...

    Bao Wang, Yuang Wei, ... Pengfei Shao in European Journal of Medical Research
    Article Open access 07 February 2024
  3. Diagnostic efficacy of [68Ga]Ga-NY104 PET/CT to identify clear cell renal cell carcinoma

    Purpose

    Most clear cell renal cell carcinoma (ccRCC) overexpresses carbonic anhydrase IX (CAIX). [ 68 Ga]Ga-NY104 is a small-molecule PET agent...

    Wenjia Zhu, Guoyang Zheng, ... Li Huo in European Journal of Nuclear Medicine and Molecular Imaging
    Article 25 June 2024
  4. Increased level of serum leucine-rich-alpha-2-glycoprotein 1 in patients with clear cell renal cell carcinoma

    Background

    Currently, no useful serum markers exist for clear cell renal cell carcinoma (ccRCC), making early detection challenging as diagnosis...

    Shotaro Nakanishi, Masato Goya, ... Seiichi Saito in BMC Urology
    Article Open access 24 April 2024
  5. Necroptosis-related genes are associated with prognostic features of kidney renal clear cell carcinoma

    Introduction

    Renal clear cell carcinoma is a common type of cancer in the adult urological system. It has a high mortality rate, with 30% of patients...

    Yiduo Wang, Ke-Hao Pan, Ming Chen in Discover Oncology
    Article Open access 25 October 2023
  6. Serum IgA as a Prognostic Beacon: Anticipating Systemic Therapy Efficacy in Metastatic Clear Cell Renal Cell Carcinoma

    Objective

    Immunotherapy-tyrosine kinase inhibitor (IO-TKI) therapy has revolutionized the treatment landscape for metastatic clear cell renal cell...

    Hong-Lei Cui, Jie Wu, ... Jian-Zhong Shou in Annals of Surgical Oncology
    Article 20 May 2024
  7. Renal cell carcinoma

    Kidney cancer accounts for 5% and 3% of all adult malignancies in men and women. Renal cell carcinoma (RCC) accounts for approximately 80% of all...

    Article Open access 07 November 2023
  8. GALNT2 targeted by miR-139-5p promotes proliferation of clear cell renal cell carcinoma via inhibition of LATS2 activation

    Polypeptide N -Acetylgalactosaminyltransferase (GALNTs) are critical enzymes that initiate mucin type-O glycosylation, and are closely associated with...

    Haisheng Yi, Lingyun Liu, ... Hongliang Wang in Discover Oncology
    Article Open access 13 March 2024
  9. Clear cell renal cell carcinoma cells show diffuse expression of phagocytotic markers through the identification of lysosome-rich eosinophilic granules

    Background

    Paneth cell-like granules (PCLG) in clear cell renal cell carcinomas (RCC) have previously been reported but were not found to express...

    Vasudevan D. Mahalingam, Oumaima S. Chaib, ... ** L. Zhang in International Urology and Nephrology
    Article 30 September 2023
  10. Upregulation of CCNB2 and a novel lncRNAs-related risk model predict prognosis in clear cell renal cell carcinoma

    Background

    Clear cell renal cell carcinoma (ccRCC) is the main type of renal cell carcinoma. Cyclin B2 (CCNB2) is a subtype of B-type cyclin that is...

    Congzhe Ren, Qihua Wang, ... **aoqiang Liu in Journal of Cancer Research and Clinical Oncology
    Article Open access 01 February 2024
  11. Upregulation of BMP1 through ncRNAs correlates with adverse outcomes and immune infiltration in clear cell renal cell carcinoma

    Background

    Renal cell carcinoma (RCC) accounts for approximately 2–3% of all adult malignancies. Clear cell renal cell carcinoma (ccRCC), which...

    Mancheng Gong, Shengxing Feng, ... Wen**g Dong in European Journal of Medical Research
    Article Open access 17 October 2023
  12. Establishment and validation of a novel disulfidptosis-related immune checkpoint gene signature in clear cell renal cell carcinoma

    Background

    Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal tumors and is associated with a unfavorable prognosis....

    Lihuan Du, Nan Zhang, ... Jiaming Wen in Discover Oncology
    Article Open access 21 June 2024
  13. Prognostic impact and immunotherapeutic implications of NETosis-related prognostic model in clear cell renal cell carcinoma

    Background

    The ramifications of necroptosis on the prognostication of clear cell renal cell carcinoma (ccRCC) remain inadequately expounded.

    ...
    **ngjun Mao, Wen Huang, ... **aolei Zhang in Journal of Cancer Research and Clinical Oncology
    Article Open access 27 May 2024
  14. High risk clear cell renal cell carcinoma microenvironments contain protumour immunophenotypes lacking specific immune checkpoints

    Perioperative immune checkpoint inhibitor (ICI) trials for intermediate high-risk clear cell renal cell carcinoma (ccRCC) have failed to consistently...

    Arti M. Raghubar, Nicholas A. Matigian, ... Andrew J. Mallett in npj Precision Oncology
    Article Open access 11 September 2023
  15. A promising natural killer cell-based model and a nomogram for the prognostic prediction of clear-cell renal cell carcinoma

    Background

    Clear-cell renal cell carcinoma (ccRCC) is one of prevalent kidney malignancies with an unfavorable prognosis. There is a need for a robust...

    Qinfan Yao, **uyuan Zhang, ... Da** Chen in European Journal of Medical Research
    Article Open access 24 January 2024
  16. Deep learning using contrast-enhanced ultrasound images to predict the nuclear grade of clear cell renal cell carcinoma

    Purpose

    To assess the effectiveness of a deep learning model using contrastenhanced ultrasound (CEUS) images in distinguishing between low-grade...

    Yun Bai, Zi-Chen An, ... Ying-Yu Cai in World Journal of Urology
    Article 21 March 2024
  17. STING is a prognostic factor related to tumor necrosis, sarcomatoid dedifferentiation, and distant metastasis in clear cell renal cell carcinoma

    STING is a molecule involved in immune reactions against double-stranded DNA fragments, released in infective and neoplastic diseases, whose role in...

    Stefano Marletta, Anna Caliò, ... Guido Martignoni in Virchows Archiv
    Article Open access 29 April 2023
  18. High Hepcidin expression predicts poor prognosis in patients with clear cell renal cell carcinoma

    Clear cell renal cell carcinoma (ccRCC) is a growing public health challenge worldwide. Hepcidin antimicrobial peptide (HAMP) is differentially...

    Yuting Tang, Shengdong Ge, ... Jiejiao Zheng in Diagnostic Pathology
    Article Open access 31 December 2022
  19. Kidney scoring surveillance: predictive machine learning models for clear cell renal cell carcinoma growth using MRI

    Introduction

    Classification of clear cell renal cell carcinoma (ccRCC) growth rates in patients with Von Hippel–Lindau (VHL) syndrome has several...

    Pouria Yazdian Anari, Aryan Zahergivar, ... Ashkan A. Malayeri in Abdominal Radiology
    Article 12 February 2024
  20. Elevated histone deacetylase 10 expression promotes the progression of clear cell renal cell carcinoma by Notch-1-PTEN signaling axis

    Background

    Clear cell renal cell carcinoma (ccRCC), the most common pathological subtype of kidney cancer, accounts for approximately 70% to 80% of...

    Bin Zheng, Xue Jiang, ... Wei He in Discover Oncology
    Article Open access 11 May 2024
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