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Interleukin-21 modulates balance between regulatory T cells and T-helper 17 cells in chronic hepatitis B virus infection
BackgroundChronic HBV infection is always accompanied by differences in the balance between regulatory T cells (Tregs) and T-helper 17 (Th17) cells...
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Direct-Acting Antiviral Therapy for Patients with Chronic Hepatitis C Infection and Decompensated Cirrhosis
Patients with chronic hepatitis C virus (HCV) infection and decompensated cirrhosis are an important population for antiviral therapy yet...
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Metabolic interventions improve HBV envelope-specific T-cell responses in patients with chronic hepatitis B
BackgroundRestoration of HBV-specific T cell immunity is a promising approach for the functional cure of chronic Hepatitis B (CHB), necessitating the...
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Immune therapies against chronic hepatitis B
Patients with chronic hepatitis B (CHB) represent a living and permanent reservoir of hepatitis B virus (HBV). Millions of these CHB patients will...
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Outcome of Infants Born to Women with Chronic Hepatitis B: A Local Risk-Based Strategy in a Low Prevalence Country
BackgroundChronic hepatitis-B virus (HBV) infection due to mother-to-child transmission (MTCT) during the perinatal period is an important global...
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Viscoelastic parameters derived from multifrequency MR elastography for depicting hepatic fibrosis and inflammation in chronic viral hepatitis
ObjectivesThe capability of MR elastography (MRE) to differentiate fibrosis and inflammation, and to provide precise diagnoses is crucial, whereas...
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Evaluation of patients treated with direct-acting anti-viral therapy for chronic hepatitis C and their risk of hepatocellular carcinoma in Hong Kong
Background & aimTo evaluate the risk of early hepatocellular carcinoma (HCC) in chronic hepatitis C patients treated with direct-acting antivirals...
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Noninvasive Tests for Liver Fibrosis in Chronic Hepatitis B Virus
Purpose of ReviewHepatitis B virus (HBV) can be a potentially life-threatening liver infection. Prior to starting therapy, the first step is to...
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Association of chronic hepatitis B infection with hepatic steatosis and injury in nonalcoholic fatty liver disease children
BackgroundThe influence of chronic hepatitis B infection (CBI) on hepatic steatosis, necroinflammation, and fibrosis in nonalcoholic fatty liver...
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Risk of dyslipidemia in chronic hepatitis B patients taking tenofovir alafenamide: a systematic review and meta-analysis
BackgroundThe aim of this study was to demonstrate how tenofovir alafenamide (TAF) and other hepatitis B treatment drugs differentially impact lipid...
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B-Clear Phase 2b Study Design: Establishing the Efficacy and Safety of Bepirovirsen in Patients with Chronic Hepatitis B Virus Infection
IntroductionBepirovirsen (GSK3228836) is an antisense oligonucleotide that induced rapid and prolonged hepatitis B surface antigen (HBsAg) reduction...
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Graves’ disease overlap** with chronic hepatitis B and methimazole-induced liver injury and autoimmune hepatitis: a case report
BackgroundLiver injury related to Graves’ Disease (GD) includes hepatotoxicity of thyroid hormone excess, drug-induced liver injury, and changes...
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When to Stop Antiviral Therapy in HBeAg-Negative Patients with Chronic Hepatitis B?
Purpose of ReviewThe strategy of finite nucleos(t)ide analogue (Nuc) therapy in HBeAg-negative patients has been increasingly accepted globally, and...
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Novel Combination Strategies With Investigational Agents for Functional Cure of Chronic Hepatitis B Infection
Purpose of ReviewFunctional cure, defined as sustained seroclearance of hepatitis B surface antigen (HBsAg), is a favorable treatment endpoint in...
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Effect of aerobic exercise training on the fat fraction of the liver in persons with chronic hepatitis B and hepatic steatosis: Trial protocol for a randomized controlled intervention trial— The FitLiver study
BackgroundThe global prevalence of chronic hepatitis B is more than 300 million people, and in Denmark, 17,000 people are estimated to have chronic...
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High-risk population of progressive hepatic fibrosis in chronic hepatitis B patients on antiviral therapy
BackgroundProgressive hepatic fibrosis leads to hepatocellular carcinoma (HCC) and decompensated cirrhosis. The aim of this study was to identify the...
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Superoxide dismutase 2 as a predictor in patients with hepatitis B virus-associated acute-on-chronic liver failure
The prognosis of hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) is critical in clinical management. We aimed to assess the...
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HBV pregenome RNA as a predictor of spontanous HBeAg seroconversion in HBeAg-positive chronic hepatitis B patients
BackgroundPrevious studies have indicated that HBV pregenome RNA (HBV pgRNA) could predict HBeAg seroconversion among the chronic hapatitis B (CHB)...
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Characteristics, Treatment Patterns, and Clinical Outcomes of Chronic Hepatitis B Across 3 Continents: Retrospective Database Study
IntroductionThe prevalence of chronic hepatitis B virus (HBV) infection is high in many countries; however, robust, real-world epidemiological data...
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Effects of entecavir and tenofovir disoproxil fumarate on the incidence and severity of COVID-19 in patients with chronic hepatitis B
BackgroundWhether different anti-hepatitis B virus (HBV) drugs have different effects on COVID-19 is controversial. We aimed to evaluate the...
