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Tendon stem/progenitor cells are promising reparative cell sources for multiple musculoskeletal injuries of concomitant articular cartilage lesions associated with ligament injuries
BackgroundTrauma-related articular cartilage lesions usually occur in conjunction with ligament injuries. Torn ligaments are frequently reconstructed...
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Inhibition of HOXD11 promotes cartilage degradation and induces osteoarthritis development
The 5′-HOXD genes are important for chondrogenesis in vertebrates, but their roles in osteoarthritis (OA) are still ambiguous. In our study, 5′-HOXD ...
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Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis
Fractures are frequently occurring diseases that endanger human health. Crucial to fracture healing is cartilage formation, which provides a...
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Pannexins in the musculoskeletal system: new targets for development and disease progression
During cell differentiation, growth, and development, cells can respond to extracellular stimuli through communication channels. Pannexin (Panx)...
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Development of primary osteoarthritis during aging in genetically diverse UM-HET3 mice
BackgroundPrimary osteoarthritis (OA) occurs without identifiable underlying causes such as previous injuries or specific medical conditions. Age is...
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The effect of hypoxia on chondrogenesis of equine synovial membrane-derived and bone marrow-derived mesenchymal stem cells
BackgroundJoint injury is extremely common in equine athletes and post-traumatic osteoarthritis (PTOA), a progressive and debilitating disease, is...
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Articular cartilage repair using autologous collagen-induced chondrogenesis (ACIC): a pragmatic and cost-effective enhancement of a traditional technique
PurposeThe autologous collagen-induced chondrogenesis technique is described, and the results of a 6-year follow-up clinical study using this...
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Sustained benefit of autologous matrix-induced chondrogenesis for hip cartilage repair in a recreational athletic population
PurposeTo investigate the clinical outcome of autologous matrix-induced chondrogenesis (AMIC) implementation for mid-sized chondral lesions of the...
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Palovarotene: First Approval
Palovarotene (Sohonos™) is an orally bioavailable selective retinoic acid receptor (RAR)γ agonist being developed by Ipsen for the reduction of...
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Characteristics of gene expression in frozen shoulder
BackgroundSevere frozen shoulder (FS) is often resistant to treatment and can thus result in long-term functional impairment. However, its etiology...
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Do Interactions of Vitamin D3 and BMP Signaling Hold Implications in the Pathogenesis of Fibrodysplasia Ossificans Progressiva?
Purpose of ReviewFibrodysplasia ossificans progressiva (FOP) is a debilitating rare disease known for episodic endochondral heterotopic ossification...
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SPECT/CT imaging features of cystic degeneration of the talus and their relation to pathological findings
BackgroundOsteochondral lesions of the talus (OLTs) are a common orthopedic condition. The image presentation is very similar to that of ischemic...
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H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair
Chondrocyte differentiation is a critical process for endochondral ossification, which is responsible for long bone development and fracture repair....
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Low-intensity photobiomodulation at 632.8 nm increases tgfβ3, col2a1, and sox9 gene expression in rat bone marrow mesenchymal stem cells in vitro
The high incidence of cartilage destructions, as well as the social and economic importance of this pathology attracted great interest to the...
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Limited evidence in support of bone marrow aspirate concentrate as an additive to the bone marrow stimulation for osteochondral lesions of the talus: a systematic review and meta-analysis
PurposeBone marrow aspirate concentrate can be used as an additive to surgical treatment of osteochondral lesions of the talus. This systematic...
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CD34+THY1+ synovial fibroblast subset in arthritic joints has high osteoblastic and chondrogenic potentials in vitro
ObjectiveSynovial fibroblasts (SFs) in rheumatoid arthritis (RA) and osteoarthritis (OA) play biphasic roles in joint destruction and regeneration of...
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Fgfr1 conditional-knockout in neural crest cells induces heterotopic chondrogenesis and osteogenesis in mouse frontal bones
Most facial bones, including frontal bones, are derived from neural crest cells through intramembranous ossification. Fibroblast growth factor...
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Hyaluronic Acid Dermal Filler Promotes Cartilage Resha** in Rabbit Ears
BackgroundNeonatal ear is more malleable and soft, allowing the correction of deformities by using external molding. This is mainly attributed to...
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Nanotechnology development in surgical applications: recent trends and developments
This paper gives a detailed analysis of nanotechnology's rising involvement in numerous surgical fields. We investigate the use of nanotechnology in...
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Recent progress on the role of miR-140 in cartilage matrix remodelling and its implications for osteoarthritis treatment
Cartilage matrix remodelling homeostasis is a crucial factor in maintaining cartilage integrity. Loss of cartilage integrity is a typical...