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Identification of CTNNB1-PLAG1 gene rearrangement in a patient with pulmonary pleomorphic adenoma
Pulmonary pleomorphic adenoma (PA) is a rare salivary gland-type neoplasm, which predominantly occurs in the proximal airway. Rearrangement of the...
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Identification of key eRNAs for intervertebral disc degeneration by integrated multinomial bioinformatics analysis
BackgroundIntervertebral disc degeneration (IVDD) is a common degenerative condition leading to abnormal stress distribution under load, causing...
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Molecular analysis of apocrine mixed tumors and cutaneous myoepitheliomas: a comparative study confirming a continuous spectrum of one entity with near-ubiquitous PLAG1 and rare mutually exclusive HMGA2 gene rearrangements
Myoepithelial neoplasms of the skin and soft tissue still represent a confusing and somewhat controversial field in pathology as it appears that this...
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SNHG10 Promotes Cell Proliferation and Migration in Gastric Cancer by Targeting miR-495-3p/CTNNB1 Axis
BackgroundLong non-coding RNAs have been acknowledged as the crucial regulators in the progression of human cancers, including gastric cancer (GC)....
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Das Two-in-one-hit-Modell der beschleunigten Genese von kolorektalen Karzinomen beim MLH1-assoziierten Lynch-Syndrom
In a recently published study a new genetic hypothesis was established that explained the existence of CTNNB1 mutations in Lynch syndrome-associated...
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The correlation between KRAS and TP53 gene mutations and early growth of pulmonary nodules
PurposeThe purpose of this study is to investigate whether gene mutations can lead to the growth of malignant pulmonary nodules.
Methods ... -
Genomic drivers in craniopharyngiomas: Analysis of the AACR project GENIE database
PurposeCraniopharyngiomas are rare tumors originating in the sellar region, with limited information on their somatic mutational landscape. In this...
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Pleomorphic Adenoma with a Novel Gene Rearrangement—LINC01606::PLAG1
BackgroundPleomorphic adenoma is a well-known benign salivary gland neoplasm characterized by the presence of varying proportions of three different...
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A programmed cell death-related gene signature to predict prognosis and therapeutic responses in liver hepatocellular carcinoma
BackgroundProgrammed cell death (PCD) functions critically in cancers and PCD-related genes are associated with tumor microenvironment (TME),...
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Characterization of the congenital diaphragmatic hernia model in C57BL/6J fetal mice: a step toward lineage tracing experiments
PurposeLineage tracing is key to study the fate of individual cells and their progeny especially in developmental biology. To conduct these studies,...
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Disrupted extracellular matrix and cell cycle genes in autism-associated Shank3 deficiency are targeted by lithium
The Shank3 gene encodes the major postsynaptic scaffolding protein SHANK3. Its mutation causes a syndromic form of autism spectrum disorder (ASD):...
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Comparing gene expression in deep infiltrating endometriosis with adenomyosis uteri: evidence for dysregulation of oncogene pathways
BackgroundThe pathogenesis of deep infiltrating endometriosis (DIE) is poorly understood. It is considered a benign disease but has histologic...
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High Expression of CARM1 Inhibits Lung Cancer Progression by Targeting TP53 by Regulating CTNNB1
ObjectiveTo explore the role of CARM1 in lung cancer (LC) and its relationship with TP53 and CTNNB1.
MethodsLung cells H1299 and PC14 were randomly...
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Network pharmacology identifies fisetin as a treatment for osteoporosis that activates the Wnt/β-catenin signaling pathway in BMSCs
BackgroundAlthough fisetin may exist widely in many natural herbs, its anti-OP mechanism is still unclear. The aim of this study is to explore the...
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Fibrolamellar hepatocellular carcinoma: a case report and gene analysis
BackgroundFibrolamellar hepatocellular carcinoma (HCC) (FL-HCC) is rare in Japan. FL-HCC develops in young patients with no history of cirrhosis and...
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Study of sex-biased differences in genomic profiles in East Asian hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is characterized by a notable sex disparity in incidence and tumor aggressiveness. Revealing differences in genetic...
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Gene expression and demographic analyses in women with the poor ovarian response: a computational approach
PurposePoor response to ovarian stimulation (POR) typically is reflected as decreased follicular response and low estradiol (E2) levels...
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β-CATENIN is a positive prognostic marker for HPV-positive head and neck squamous cell carcinoma
PurposeThe evolutionary-conserved Wnt/β-CATENIN (WBC) pathway has been implicated in the pathogenesis of different solid malignant tumors. We...
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Comparison of gene mutation profile in different lung adenocarcinoma subtypes by targeted next-generation sequencing
BackgroundDisease prognosis after resection of lung cancer could be affected by pathological subtypes. In this study, we investigated the difference...
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Can MRI features predict clinically relevant hepatocellular carcinoma genetic subtypes?
PurposeRecent studies in cancer genomics have revealed core drivers for hepatocellular carcinoma (HCC) pathogenesis. We aim to study whether MRI...
