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Brivaracetam Retention Rate and Seizure Outcomes in Patients with Drug-Resistant Focal Epilepsy Included in the Medical Need Program in Belgium: A Real-World, Multicenter, Chart Review
BackgroundNew treatments are needed for patients with drug-resistant epilepsy to improve seizure control without decreasing quality of life.
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Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A
BackgroundAntiepileptic drugs, levetiracetam (LEV) and brivaracetam (BRV), bind to synaptic vesicle glycoprotein 2A (SV2A). In their anti-seizure...
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Effect of Number of Previous Antiseizure Medications on Efficacy and Tolerability of Adjunctive Brivaracetam for Uncontrolled Focal Seizures: Post Hoc Analysis
IntroductionThe aim was to evaluate the efficacy and tolerability of adjunctive brivaracetam (BRV) in adults with severely drug-resistant focal...
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Newer Antiseizure Medications and Suicidality: Analysis of the Food and Drug Administration Adverse Event Reporting System (FAERS) Database
BackgroundThe association between antiseizure medications (ASMs) and suicidality remains controversial. Analyses of additional datasets are needed to...
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Third-Generation Antiseizure Medication in the Treatment of Benzodiazepine-Refractory Status Epilepticus in Poststroke Epilepsy: A Retrospective Observational Register-Based Study
Background and ObjectiveStatus epilepticus in poststroke epilepsy is a challenging condition because of multiple vascular comorbidities and the...
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Die neuen anfallsunterdrückenden Medikamente für das Kindes- und Jugendalter
Since the introduction of bromide into epilepsy treatment one third of all patients in childhood and adolescence are still resistant to treatment....
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Economic Value of Adjunctive Brivaracetam Treatment Strategy for Focal Onset Seizures in Finland
IntroductionThere is an unmet need for well-tolerated antiepileptic drugs (AEDs) that effectively control focal onset seizures. This study aimed to...
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Rapidity of CNS Effect on Photoparoxysmal Response for Brivaracetam vs. Levetiracetam: A Randomized, Double-blind, Crossover Trial in Photosensitive Epilepsy Patients
IntroductionBoth levetiracetam (LEV) and brivaracetam (BRV) eliminate the electroencephalogram photoparoxysmal response (PPR) in the human phase IIa...
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Intravenous Brivaracetam in the Treatment of Status Epilepticus: A Systematic Review
BackgroundBrivaracetam is a high-affinity synaptic vesicle glycoprotein 2A ligand with high brain permeability and rapid onset of action. These...
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Neue Entwicklungen in der antikonvulsiven Therapie bei Menschen mit Intelligenzminderung
The frequency of epilepsy is significantly higher in people with intellectual disability (PID) compared to other patients. Epilepsy in PID is often...