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The Bone-Vascular Axis in Chronic Kidney Disease: From Pathophysiology to Treatment
Purpose of ReviewThis review aims to describe the pathogenic factors involved in bone-vessel anomalies in CKD which are the object of numerous...
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Fragile X Messenger Ribonucleoprotein 1 (FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice
Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene mutations lead to fragile X syndrome, cognitive disorders, and, in some individuals, scoliosis...
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Bone and growth: basic principles behind rare disorders
The heterogeneity of “rare bone disorders” can be explained by the number of molecules and regulatory pathways which are responsible for bone health...
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Latent metabolic bone disease, skeletal dysplasia and other conditions related to low bone formation among 38 patients with subtrochanteric femoral fractures: a retrospective observational study
SummarySubtrochanteric femoral fracture is rare and intractable due to the possible association with low bone formation. Retrospective analysis of 38...
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Disorders of phosphate homeostasis in children, part 1: primer on mineral ion homeostasis and the roles of phosphate in skeletal biology
Phosphate has extensive physiological roles including energy metabolism, genetic function, signal transduction and membrane integrity. Regarding the...
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Bone metabolism – an underappreciated player
Bone is constantly being remodeled, and this process is orchestrated by a dynamic crosstalk of bone cells, including osteoclasts, osteoblasts, and...
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ERK-estrogen receptor α signaling plays a role in the process of bone marrow mesenchymal stem cell-derived exosomes protecting against ovariectomy-induced bone loss
BackgroundExosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) are considered as candidates for osteoporosis (OP) therapy. Estrogen...
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SP7: from Bone Development to Skeletal Disease
Purpose of ReviewThe purpose of this review is to summarize the different roles of the transcription factor SP7 in regulating bone formation and...
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One musculoskeletal health: towards optimizing musculoskeletal health in Egypt—how to be a bone and muscle builder by the Egyptian Academy of Bone Health and Metabolic Bone Diseases
BackgroundMusculoskeletal disorders are common problems that affect the elderly. They severely restrict mobility and dexterity, resulting in early...
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Bone-organ axes: bidirectional crosstalk
In addition to its recognized role in providing structural support, bone plays a crucial role in maintaining the functionality and balance of various...
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Association of chronic liver disease with bone diseases and muscle weakness
The liver is a vital organ involved in nutrient metabolism, hormone regulation, immunity, cytokine production, and gut homeostasis. Impairment in...
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Bone quality in endocrine diseases: determinants and clinical relevance
PurposeBone is one of the main targets of hormones and endocrine diseases are frequent causes of secondary osteoporosis and fractures in real-world...
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The brain–bone axis: unraveling the complex interplay between the central nervous system and skeletal metabolism
The brain–bone axis has emerged as a captivating field of research, unveiling the intricate bidirectional communication between the central nervous...
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Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status
Bone formation is a highly energy-demanding process that can be impacted by metabolic disorders. Glucose has been considered the principal substrate...
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Low bone mineral density is associated with fatty liver disease and respiratory illness in a pediatric mortality sample
SummaryThis study finds that fatty liver disease is associated with low bone density in a pediatric mortality sample. Since non-alcoholic fatty liver...
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Hypopituitarism and bone disease: pathophysiology, diagnosis and treatment outcomes
Hypopituitarism is a rare but significant endocrine disorder characterized by the inadequate secretion of one or more pituitary hormones. The...
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Methods for bone quality assessment in human bone tissue: a systematic review
BackgroundFor biomechanical investigations on bone or bone implants, bone quality represents an important potential bias. Several techniques for...
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Secreted microRNAs in bone metastasis
Bone metastasis is a common complication in several solid cancers, including breast, prostate, and lung. In the bone microenvironment, metastatic...
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Bone Trans-omics: Integrating Omics to Unveil Mechanistic Molecular Networks Regulating Bone Biology and Disease
Purpose of ReviewRecent advancements in “omics” technologies and bioinformatics have afforded researchers new tools to study bone biology in an...
