Search
Search Results
-
Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice
Aims/hypothesisBeta cells control glucose homeostasis via regulated production and secretion of insulin. This function arises from a highly...
-
Intra-islet insulin synthesis defects are associated with endoplasmic reticulum stress and loss of beta cell identity in human diabetes
Aims/hypothesisEndoplasmic reticulum (ER) stress and beta cell dedifferentiation both play leading roles in impaired insulin secretion in overt type...
-
Progressive endoplasmic reticulum stress over time due to human insulin gene mutation contributes to pancreatic beta cell dysfunction
Aims/hypothesisWe studied the effects of heterozygous human INS gene mutations on insulin secretion, endoplasmic reticulum (ER) stress and other...
-
-
Apolipoprotein L genes are novel mediators of inflammation in beta cells
Aims/hypothesisInflammation induces beta cell dysfunction and demise but underlying molecular mechanisms remain unclear. The apolipoprotein L (APOL)...
-
Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped
Aims/hypothesisThe rapid remission of type 2 diabetes by a diet very low in energy correlates with a marked improvement in glucose-stimulated insulin...
-
The efficiency of stem cell differentiation into functional beta cells for treating insulin-requiring diabetes: Recent advances and current challenges
In recent years, the potential of stem cells (SCs) to differentiate into various types of cells, including β-cells, has led to a significant boost in...
-
Endocrinopathies in beta thalassemia: a narrative review
Beta thalassemia is the most common genetic blood disorder, characterized by reduced production or complete absence of beta-globin chains. The...
-
Higher systolic blood pressure is specifically associated with better islet beta-cell function in T2DM patients with high glycemic level
BackgroundPatients with type 2 diabetes mellitus (T2DM) usually have higher blood viscosity attributed to high blood glucose that can decrease blood...
-
Effect of hydroxychloroquine on beta cell function, insulin resistance, and inflammatory markers in type 2 diabetes patients uncontrolled on glimepiride and metformin therapy
BackgroundVery few studies have assessed the impact of hydroxychloroquine (HCQ) on insulin resistance, beta cell function, and inflammatory markers...
-
Congenital beta cell defects are not associated with markers of islet autoimmunity, even in the context of high genetic risk for type 1 diabetes
Aims/hypothesisA key unanswered question in type 1 diabetes is whether beta cells initiate their own destruction or are victims of an aberrant immune...
-
A new beta cell-specific mitophagy reporter mouse shows that metabolic stress leads to accumulation of dysfunctional mitochondria despite increased mitophagy
Aims/hypothesisMitophagy, the selective autophagy of mitochondria, is essential for maintenance of mitochondrial function. Recent studies suggested...
-
Beta-Blockers in Pregnancy: Clinical Update
Purpose of ReviewThe aim of this review was to determine the anticipated benefits and adverse effects of beta-blockers in pregnant women with...
-
Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia
Obesity and insulin resistance are associated with the development of type 2 diabetes. It is well accepted that beta cell dysfunction is required for...
-
Urolithin C alleviates pancreatic β-cell dysfunction in type 1 diabetes by activating Nrf2 signaling
AimsType 1 diabetes (T1D) is an autoimmune disorder that destroys insulin-generating pancreatic β-cells. Preserving pancreatic β-cell function is...
-
Differential patterns of lysosomal dysfunction are seen in the clinicopathological forms of primary progressive aphasia
Increasing evidence implicates endo-lysosomal dysfunction in frontotemporal dementia (FTD). 18 proteins were quantified using a mass spectrometry...
-
Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function
Aims/hypothesisSouth Asians in general, and Asian Indians in particular, have higher risk of type 2 diabetes compared with white Europeans, and a...
-
B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis
Hyperhomocysteinemia (HHcy) is a risk factor for chronic kidney diseases (CKDs) that affects about 85% CKD patients. HHcy stimulates B cells to...
-
Role of angiogenesis in beta-cell epithelial–mesenchymal transition in chronic pancreatitis-induced diabetes
Clinical evidence suggests that patients with chronic pancreatitis (CP) are prone to development of diabetes (chronic pancreatitis-related diabetes;...
-
Beta cell dysfunction in diabetes: the islet microenvironment as an unusual suspect
Cells in different tissues, including endocrine cells in the pancreas, live in complex microenvironments that are rich in cellular and acellular...
