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Baseline symptom-related white matter tracts predict individualized treatment response to 12-week antipsychotic monotherapies in first-episode schizophrenia
There is significant heterogeneity in individual responses to antipsychotic drugs, but there is no reliable predictor of antipsychotics response in...
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A data-driven approach to categorizing early life adversity exposure in the ABCD Study
BackgroundAdversity occurring during development is associated with detrimental health and quality of life outcomes, not just following exposure but...
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Combination of UGT1A1 polymorphism and baseline plasma bilirubin levels in predicting the risk of antipsychotic-induced dyslipidemia in schizophrenia patients
The prolonged usage of atypical antipsychotic drugs (AAPD) among individuals with schizophrenia often leads to metabolic side effects such as...
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Tofacitinib as a maintenance therapy in patients with ulcerative colitis stratified by OCTAVE Sustain baseline Mayo endoscopic subscore
BackgroundTofacitinib is an oral small molecule Janus kinase inhibitor for the treatment of ulcerative colitis. We evaluated tofacitinib efficacy and...
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Statins and new-onset diabetes in primary prevention setting: an updated meta-analysis stratified by baseline diabetes risk
AimsThe use of statins has been associated with an increased risk of new-onset diabetes. The characteristics of the population could influence this...
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Can peripheral psychophysiological markers predict response to exposure-based cognitive behavioral therapy in youth with severely impairing irritability? A study protocol
BackgroundIrritability, an increased proneness to anger, is a primary reason youth present for psychiatric care. While initial evidence supports the...
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Consistent Efficacy of Apremilast in Patients with Psoriasis Regardless of Baseline Disease Severity or Special Area Involvement: Subgroup Analysis from PROMINENT
IntroductionPsoriasis involvement in special areas (e.g., scalp or nails) is associated with a great disease burden yet it is often inadequately...
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Cumulative exposure to AHA Life's Essential 8 is associated with nonalcoholic fatty liver disease: a large cohort study
Background and AimWe aimed to explore the associations of baseline and cumulative cardiovascular health with nonalcoholic fatty liver disease (NAFLD)...
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Aqueous shunt exposure repair: outcomes and risk factors for recurrence
ObjectiveTo investigate the outcomes of aqueous shunt exposure repair and to identify risk factors for recurrent exposure after surgical repair.
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Medication exposure of the dyad patient-caregiver in Alzheimer’s disease and related dementias: a cross-sectional study
BackgroundPatients with Alzheimer’s disease and related dementias and their caregivers can be defined as people with higher risk of develo**...
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Predicting personal PAH exposure using high dimensional questionnaire and wristband data
BackgroundPolycyclic aromatic hydrocarbons (PAHs) are a class of pervasive environmental pollutants with a variety of known health effects. While...
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Declining incidence rate of tuberculosis among close contacts in five years post-exposure: a systematic review and meta-analysis
BackgroundIndividuals in close contact with active pulmonary tuberculosis (TB) patients showed a high risk of recent infection and, once infected,...
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Consequences of ionizing radiation exposure to the cardiovascular system
Ionizing radiation is widely used in various industrial and medical applications, resulting in increased exposure for certain populations. Lessons...
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Sha** tomorrow’s support: baseline clinical characteristics predict later social functioning and quality of life in schizophrenia spectrum disorder
PurposeWe aimed to explore the multidimensional nature of social inclusion (mSI) among patients diagnosed with schizophrenia spectrum disorder (SSD),...
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Longitudinal predictors of post-exposure prophylaxis awareness among latino sexual minority men in South Florida
Biomedical tools for HIV prevention such as post-exposure prophylaxis (PEP) continue to be underutilized by subgroups experiencing significant HIV...
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Baseline characteristics from a 3-year longitudinal study to phenotype subjects with COPD: the FOOTPRINTS study
BackgroundFOOTPRINTS ® is a prospective, longitudinal, 3-year study assessing the association between biomarkers of inflammation/lung tissue...
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Risk factors of adolescent exposure to violence in Burkina Faso
BackgroundGlobally violence against children and adolescents is a significant public health problem. Since children rely on family for early learning...
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Exposure–Response Efficacy Modeling to Support Trofinetide Dosing in Individuals with Rett Syndrome
IntroductionTrofinetide was recently approved for the treatment of Rett syndrome (RTT) on the basis of the efficacy and safety findings of the...
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Impact of low-level prenatal alcohol exposure and maternal stress on autonomic regulation
BackgroundPrenatal alcohol exposure (PAE) impacts the neurodevelopment of the fetus, including the infant’s ability to self-regulate. Heart rate...
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Nasal oxidative stress mediating the effects of colder temperature exposure on pediatric asthma symptoms
BackgroundColder temperature exposure is a known trigger for pediatric asthma exacerbation. The induction of oxidative stress is a known...
