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Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?
A perplexing feature of type 1 diabetes (T1D) is that the immune system destroys pancreatic β-cells but not neighbouring α-cells, even though both...
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First-appearing islet autoantibodies for type 1 diabetes in young children: maternal life events during pregnancy and the child’s genetic risk
Aims/hypothesisPsychological stress has long been considered a possible trigger of type 1 diabetes, although prospective studies examining the link...
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Blood levels of T-Cell Receptor Excision Circles (TRECs) provide an index of exposure to traumatic stress in mice and humans
Exposure to stress triggers biological changes throughout the body. Accumulating evidence indicates that alterations in immune system function are...
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Dendritic cell-derived IL-27 p28 regulates T cell program in pathogenicity and alleviates acute graft-versus-host disease
Interleukin 27 (IL-27), a heterodimeric cytokine composed of Epstein-Barr virus-induced 3 and p28, is a pleiotropic cytokine with both pro-and...
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Immune Memory in Aging: a Wide Perspective Covering Microbiota, Brain, Metabolism, and Epigenetics
Non-specific innate and antigen-specific adaptive immunological memories are vital evolutionary adaptations that confer long-lasting protection...
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Mitigating Serious Adverse Events in Gene Therapy with AAV Vectors: Vector Dose and Immunosuppression
Gene transfer with high doses of adeno-associated viral (AAV) vectors has resulted in serious adverse events and even death of the recipients....
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The dual role and mutual dependence of heme/HO-1/Bach1 axis in the carcinogenic and anti-carcinogenic intersection
IntroductionIn physiological concentrations, heme is nontoxic to the cell and is essential for cell survival and proliferation. Increasing...
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Novel Genetic Discoveries in Primary Immunodeficiency Disorders
The field of Immunology is one that has undergone great expansion in recent years. With the advent of new diagnostic modalities including a variety...
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Necroptosis-related genes are associated with prognostic features of kidney renal clear cell carcinoma
IntroductionRenal clear cell carcinoma is a common type of cancer in the adult urological system. It has a high mortality rate, with 30% of patients...
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Novel Developments in Primary Immunodeficiencies (PID)—a Rheumatological Perspective
Purpose of ReviewThe purpose of this review is to provide an overview of the most relevant new disorders, disease entities, or disease phenotypes of...
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Genomic landscape of mature B-cell non-Hodgkin lymphomas — an appraisal from lymphomagenesis to drug resistance
BackgroundMature B-cell non-Hodgkin lymphomas are one of the most common hematological malignancies with a divergent clinical presentation,...
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Association of rare variants in genes of immune regulation with pediatric autoimmune CNS diseases
BackgroundThere is a gap in the literature regarding genetic underpinnings of pediatric autoimmune CNS diseases. This study explored rare gene...
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Reflections on the state of diabetes research and prospects for treatment
Research on the etiology and treatment of diabetes has made substantial progress. As a result, several new classes of anti-diabetic drugs have been...
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Neues zu Pathogenese und molekularem Verständnis bei kutanen T-Zell-Lymphomen
The pathogenesis of cutaneous T‑cell lymphomas (CTCL) is still an enigma. Therefore, extensive translational research efforts have been undertaken in...
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Autoimmune liver disease and multiple sclerosis: state of the art and future perspectives
Clinical observations suggest that the prevalence of autoimmune diseases is changing over time. Both autoimmune liver diseases and multiple sclerosis...
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The pediatric common variable immunodeficiency — from genetics to therapy: a review
Common variable immunodeficiency (CVID) is the most prevalent antibody deficiency, characterized by remarkable genetic, immunological, and clinical...
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Treg-associated monogenic autoimmune disorders and gut microbial dysbiosis
AbstractPrimary immunodeficiency diseases (PIDs) caused by a single-gene defect generally are referred to as monogenic autoimmune disorders. For...
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Association of rs4711998 of IL-17A, rs2275913 of IL-17A and rs763780 IL-17F gene polymorphisms with non-segmental vitiligo in a Mexican population
Vitiligo is the most common depigmenting disease characterized by achromic macules due to selective loss of melanocytes. The pathogenesis remains...