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Proteomic comparison between physiological degeneration and needle puncture model of disc generation disease
BackgroundThe completeness of the intervertebral disc proteome is fundamental to the integrity and functionality of the intervertebral disc.
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Development of a rat model with lumbar vertebral endplate lesion
PurposeVertebral endplate lesion (EPL) caused by severe disc degeneration is associated with low back pain. However, there is no suitable animal...
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Transcriptional profiling of human cartilage endplate cells identifies novel genes and cell clusters underlying degenerated and non-degenerated phenotypes
BackgroundLow back pain is a leading cause of disability worldwide and is frequently attributed to intervertebral disc (IVD) degeneration. Though the...
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Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases
Degenerative musculoskeletal diseases are structural and functional failures of the musculoskeletal system, including osteoarthritis, osteoporosis,...
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A roadmap for delivering a human musculoskeletal cell atlas
Advances in single-cell technologies have transformed the ability to identify the individual cell types present within tissues and organs. The...
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Single-cell RNA-seq analysis reveals the Wnt/Ca2+ signaling pathway with inflammation, apoptosis in nucleus pulposus degeneration
BackgroundIncreasing studies have shown degeneration of nucleus pulposus cells (NPCs) as an critical part of the progression of intervertebral disc...
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A Heterologous Fibrin Glue Enhances the Closure Effect of Surgical Suture on the Repair of Annulus Fibrous Defect in a Sheep Model
Improving the closure effect of surgical suture for repair of annulus fibrosus defects remains an unsolved problem. A new type of porcine fibrin glue...
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Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy
PurposeTo construct an injectable, sustained-release fibrin gel containing rhein to solve the problem of low bioavailability of rhein, and observe...
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Interleukin-1β and cathepsin D modulate formation of the terminal complement complex in cultured human disc tissue
PurposeFormation of terminal complement complex (TCC), a downstream complement system activation product inducing inflammatory processes and cell...
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Percutaneous endoscopic lumbar discectomy combined with platelet-rich plasma injection for lumbar disc herniation: analysis of clinical and imaging outcomes
ObjectiveTo evaluate the clinical efficacy and imaging outcomes of percutaneous endoscopic lumbar discectomy (PELD) combined with platelet-rich...
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Intradiscal injection of monosodium iodoacetate induces intervertebral disc degeneration in an experimental rabbit model
BackgroundEstablishing an optimal animal model for intervertebral disc (IVD) degeneration is essential for develo** new IVD therapies. The...
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Icariin regulates stem cell migration for endogenous repair of intervertebral disc degeneration by increasing the expression of chemotactic cytokines
BackgroundIcariin (ICA) can promote the migration and bone formation of bone marrow mesenchymal stem cells. This study explored a potential role of...
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Nutritional deficiency induces nucleus pulposus cell apoptosis via the ATF4-PKM2-AKT signal axis
BackgroundThe intervertebral disc is the largest avascular tissue in the human body. The nucleus pulposus (NP) consumes glucose and oxygen to...
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Serum and nutrient deprivation increase autophagic flux in intervertebral disc annulus fibrosus cells: an in vitro experimental study
PurposeThe loss of nutrient supply is a suspected contributor of intervertebral disc degeneration. However, the extent to which low nutrition affects...
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Influence of endplate avulsion and Modic changes on the inflammation profile of herniated discs: a proteomic and bioinformatic approach
PurposeThe aim of this observational radiographic and proteomic study is to explore the influence of both Modic change (MC) and endplate avulsion...
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Intervertebral disc degeneration and osteoarthritis: a common molecular disease spectrum
Intervertebral disc degeneration (IDD) and osteoarthritis (OA) affecting the facet joint of the spine are biomechanically interdependent, typically...
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Bionate® nucleus disc replacement: bench testing comparing two different designs
BackgroundIntervertebral disc nucleus degeneration initiates a degenerative cascade and can induce chronic low back pain. Nucleus replacement aims to...
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Molecular Regulation of Cardiac Conduction System Development
Purpose of reviewThe cardiac conduction system, composed of pacemaker cells and conducting cardiomyocytes, orchestrates the propagation of electrical...
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Comparisons between needle puncture and chondroitinase ABC to induce intervertebral disc degeneration in rabbits
PurposeThis study aimed to compare the effect of needle puncture and chondroitinase ABC (ChABC) injection on inducing intervertebral disc (IVD)...
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Low back pain and osteoarthritis pain: a perspective of estrogen
Low back pain (LBP) is the world’s leading cause of disability and is increasing in prevalence more rapidly than any other pain condition....
