Search
Search Results
-
Effects of glutamine on plasma protein and inflammation in postoperative patients with colorectal cancer: a meta-analysis of randomized controlled trials
ObjectiveTo evaluate the effects of glutamine on the plasma protein and inflammatory responses in colorectal cancer (CRC) patients following radical...
-
Characterization of Plasma SDS-Protein Aggregation Profile of Patients with Heart Failure with Preserved Ejection Fraction
This study characterizes the plasma levels and composition of SDS-resistant aggregates (SRAs) in patients with heart failure with preserved ejection...
-
Diagnostic accuracy of pancreatic stone protein in patients with sepsis: a systematic review and meta-analysis
BackgroundSepsis is a common syndrome of multiorgan system dysfunction secondary to the dysregulated inflammatory response to infection. The role of...
-
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders
Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors. Identifying treatment targets is challenging because the...
-
Destroying pathogen-tumor symbionts synergizing with catalytic therapy of colorectal cancer by biomimetic protein-supported single-atom nanozyme
The crucial role of intratumoral bacteria in the progression of cancer has been gradually recognized with the development of sequencing technology....
-
Human papillomavirus E7 protein induces homologous recombination defects and PARPi sensitivity
PurposeCervical cancer is a common gynecological malignancy, pathologically associated with persistent infection of high-risk types of human...
-
The effects of higher versus lower protein delivery in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials with trial sequential analysis
BackgroundA recent large multicentre trial found no difference in clinical outcomes but identified a possibility of increased mortality rates in...
-
Cryo-EM structures of prion protein filaments from Gerstmann–Sträussler–Scheinker disease
Prion protein (PrP) aggregation and formation of PrP amyloid (APrP) are central events in the pathogenesis of prion diseases. In the dominantly...
-
The RING finger protein family in health and disease
Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in all eukaryotes regulating thousands of proteins. The...
-
Preparation and characterization of BSA as a model protein loaded chitosan nanoparticles for the development of protein-/peptide-based drug delivery system
BackgroundThe purpose of this study was to develop protein-/peptide-loaded nanoparticle-based delivery system, which can efficiently deliver...
-
Harmonization of maternal balanced energy-protein supplementation studies for individual participant data (IPD) meta-analyses – finding and creating similarities in variables and data collection
BackgroundPublic health and clinical recommendations are established from systematic reviews and retrospective meta-analyses combining effect sizes,...
-
Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses
Chronic mental illnesses (CMIs) pose a significant challenge to global health due to their complex and poorly understood etiologies and hence,...
-
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein
Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however, an increasing number of reports indicate that SARS-CoV-2 infection...
-
Identification of hot regions in hub protein–protein interactions by clustering and PPRA optimization
BackgroundProtein–protein interactions (PPIs) are the core of protein function, which provide an effective means to understand the function at cell...
-
Protein clearance strategies for disease intervention
Protein homeostasis, or proteostasis, is essential for cell function and viability. Unwanted, damaged, misfolded and aggregated proteins are degraded...
-
Expression of phosphorylated ribosomal protein S6 in mesothelioma patients - correlation with clinico-pathological characteristics and outcome: results from the European Thoracic Oncology Platform (ETOP) Mesoscape project
Pleural mesothelioma (PM) is an aggressive malignancy with poor prognosis. Although histology and pathologic stage are important prognostic factors,...
-
Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential
Pathology consisting of intracellular aggregates of alpha-Synuclein (α-Syn) spread through the nervous system in a variety of neurodegenerative...
-
Prion-like properties of the mutant huntingtin protein in living organisms: the evidence and the relevance
If theories postulating that pathological proteins associated with neurodegenerative disorders behave similarly to prions were initially viewed with...
-
Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrPC, in type 1 diabetes
Aims/hypothesisNormal cellular prion protein (PrP C ) is a conserved mammalian glycoprotein found on the outer plasma membrane leaflet through a...
