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Combined RT-qPCR and pyrosequencing of a Spike glycoprotein polybasic cleavage motif can uncover pediatric SARS-CoV-2 infections associated with heterogeneous presentation
BackgroundReverse transcription of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (+)RNA genome and subgenomic RNAs (sgRNAs) and...
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A shared motif of hla-dpb1 affecting the susceptibility to pr3-anca positive granulomatosis with polyangiitis: comparative analysis of a Turkish cohort with matched healthy controls
We aimed to analyse the distribution of HLA Class 2 genotypes which were reported among the genetic risk factors for ANCA-associated vasculitis (AAV)...
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Characterization of extrachromosomal circular DNAs in plasma of patients with clear cell renal cell carcinoma
Background and PurposeExtrachromosomal circular DNAs (eccDNAs) have been recognized for their significant involvement in numerous biological...
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ChIP-seq analysis found IL21R, a target gene of GTF2I–the susceptibility gene for primary biliary cholangitis in Chinese Han
AimsAimed to identify a new susceptibility gene associated with primary biliary cholangitis (PBC) in Chinese Han and investigate the possible...
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Clinical significance of urinary inflammatory biomarkers in patients with IgA nephropathy
BackgroundIgA nephropathy (IgAN) is the most common type of primary glomerulonephritis, although the definitive markers are unknown. We aimed to...
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Asperuloside inhibits the activation of pancreatic cancer-associated fibroblasts via activating transcription factor 6
BackgroundPancreatic cancer-associated fibroblasts (CAFs) play a crucial role in tumor progression and immune evasion. Asperuloside (ASP) is an...
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CCL11/CCR3-dependent eosinophilia alleviates malignant pleural effusions and improves prognosis
Malignant pleural effusion (MPE) is a common occurrence in advanced cancer and is often linked with a poor prognosis. Eosinophils were reported to...
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YAP/TAZ interacts with RBM39 to confer resistance against indisulam
The Hippo pathway and its downstream effectors, Yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ), are essential...
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Discovery of circulating blood biomarkers in patients with and without Modic changes of the lumbar spine: a preliminary analysis
PurposeThe following study aimed to determine the existence of blood biomarkers in symptomatic patients with or without lumbar Modic changes (MC).
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The Role of CCL3 in the Pathogenesis of Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease of unexplained causes. Its pathological features include synovial tissue hyperplasia,...
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RNA-binding motif protein 10 induces apoptosis and suppresses proliferation by activating p53
RNA-binding motif protein 10 (RBM10) is an RNA-binding protein frequently deleted or mutated in lung cancer cells. Recent reports showed that the...
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CXCL5 suppression recovers neovascularization and accelerates wound healing in diabetes mellitus
BackgroundHigher chemokine C-X-C motif ligand 5 (CXCL5) level was observed in type 2 diabetes mellitus (DM) patients; however, its role in diabetic...
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Autocrine pro-legumain promotes breast cancer metastasis via binding to integrin αvβ3
Tumor metastasis is the leading cause of cancer-associated mortality. Unfortunately, the underlying mechanism of metastasis is poorly understood....
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Novel mutations in the 3-box motif of the BACK domain of KLHL7 associated with nonsyndromic autosomal dominant retinitis pigmentosa
BackgroundMutations in the Kelch-like protein 7 ( KLHL7) represent a recently described and, to date, poorly characterized etiology of inherited...
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Deregulation in adult IgA vasculitis skin as the basis for the discovery of novel serum biomarkers
IntroductionImmunoglobulin A vasculitis (IgAV) in adults has a variable disease course, with patients often develo** gastrointestinal and renal...
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Combination of urinary biomarkers and machine-learning models provided a higher predictive accuracy to predict long-term treatment outcomes of patients with interstitial cystitis/bladder pain syndrome
PurposeTo identify predictive factors for satisfactory treatment outcome of the patients with IC/BPS using urine biomarkers and machine-learning...
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Cytokine profiles in the aqueous humor following brolucizumab administration for exudative age-related macular degeneration
PurposeTo identify the inflammatory cytokine profile in the aqueous humor (AH) of patients with intraocular inflammation (IOI) after intravitreal...
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Analysis and occurrence of biallelic pathogenic repeat expansions in RFC1 in a German cohort of patients with a main clinical phenotype of motor neuron disease
Biallelic pathogenic repeat expansions in RFC1 were recently identified as molecular origin of cerebellar ataxia, neuropathy, vestibular areflexia...
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Pathogenic missense variation in PABPC1L/EPAB causes female infertility due to oocyte maturation arrest at the germinal vesicle stage
Women undergoing controlled ovarian hyperstimulation prior to in vitro fertilization (IVF) are treated using various protocols to induce multiple...
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Prevalence of intronic repeat expansions in RFC1 in Dutch patients with CANVAS and adult-onset ataxia
Recently, an intronic biallelic (AAGGG) n repeat expansion in RFC1 was shown to be a cause of CANVAS and adult-onset ataxia in multiple populations....
