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Effects of Levetiracetam on neural tube development and closure of the chick embryos in ovo
PurposeEffects of Levetiracetam (LEV) within its therapeutic range at a 50 mg/kg dose for the chick embryo in ovo has been studied in order to...
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Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder
Major depressive disorder (MDD) is a common psychiatric illness characterized by low mood and loss of interest in pleasurable activities. Despite...
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Seizure control with antiepileptic drug therapy in 517 consecutive adult outpatients at the Kork Epilepsy Centre
In order to assess the efficacy of modern antiepileptic drug (AED) therapy, we collected data from 517 consecutive adult outpatients referred to our...
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Therapeutisches Management bei Patienten mit tumorassoziierter Epilepsie
Epileptic seizures are common in patients with brain tumors. They occur in up to 60–80% of patients and depend on entity, malignancy, location, and...
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Drug Interactions with the Newer Antiepileptic Drugs (AEDs)—Part 1: Pharmacokinetic and Pharmacodynamic Interactions Between AEDs
Since 1989 there has been an exponential introduction of new antiepileptic drugs (AEDs) into clinical practice and these include eslicarbazepine...
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Treatment of Nonconvulsive Status Epilepticus
Status epilepticus is a neurologic emergency with significant potential morbidity and even mortality. It should be diagnosed and treated as quickly...
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Seizure prophylaxis and melanoma brain metastases
Melanoma has a high propensity to metastasize to the brain. In patients with brain metastases (BM) survival is limited, neurologic morbidity is high,...
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Spotlight on Levetiracetam in Epilepsy
Levetiracetam (Keppra®, E Keppra®) is an established second-generation antiepileptic drug (AED). Worldwide, levetiracetam is most commonly approved...
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Evidence of novel fine-scale structural variation at autism spectrum disorder candidate loci
BackgroundAutism spectrum disorders (ASD) represent a group of neurodevelopmental disorders characterized by a core set of social-communicative and...
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Review of Therapeutic Options for Adjuvant Treatment of Focal Seizures in Epilepsy
Epilepsy is one of the most common serious neurological conditions worldwide, with an age-adjusted incidence of approximately 50 per 100 000 persons...
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Treatment of Pediatric Status Epilepticus
Status epilepticus is characterized by a prolonged, self-sustaining seizure or repeated seizures without return to baseline. The clinical...
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Levetiracetam
Levetiracetam (Keppra®, E Keppra®) is an established second-generation anti-epileptic drug (AED). Worldwide, levetiracetam is most commonly approved...
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Clavulanic acid does not affect convulsions in acute seizure tests in mice
Clavulanic acid (CLAV) inhibits bacterial β-lactamases and is commonly used to aid antibiotic therapy. Prompted by the initial evidence suggestive of...
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Antiepileptika bei Kindern
More than 20 approved substances are currently available for the treatment of epilepsy, doubling the number of antiepileptics (AE) available 20 years...
