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Neuroprotective effect of levetiracetam on hypoxic ischemic brain injury in neonatal rats
PurposeHypoxic-ischemic brain injury that occurs in the perinatal period is one of the leading causes of mental retardation, visual and auditory...
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Synaptisches Vesikelprotein 2A
Both levetiracetam (LEV) and brivaracetam (BRV) specifically bind to the synaptic vesicle protein 2A (SV2A). Synaptic vesicle protein 2A is part of...
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The role of genes co-amplified with nicastrin in breast invasive carcinoma
Breast cancer accounts for more than 450,000 deaths per year worldwide. Discovery of novel therapeutic targets that will allow patient-tailored...
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Newer anti-epileptic drugs
Need and Purpose of reviewA number of newer anti-epileptic drugs have been developed in the last few years to improve the treatment outcomes in...
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Stress and corticosterone increase the readily releasable pool of glutamate vesicles in synaptic terminals of prefrontal and frontal cortex
Stress and glucocorticoids alter glutamatergic transmission, and the outcome of stress may range from plasticity enhancing effects to noxious,...
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Levetiracetam Has Opposite Effects on Alcohol- and Cocaine-Related Behaviors in C57BL/6J Mice
The antiepileptic drug levetiracetam (LEV) is a potential treatment for alcohol use disorders, yet few preclinical studies exist on its effects in...
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Levetiracetam add-on therapy in Japanese patients with refractory partial epilepsy
The aim of this observational study was to obtain information regarding efficacy and safety of add-on levetiracetam (LEV; n =32) in Japanese patients...
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Retinal proteome alterations in a mouse model of type 2 diabetes
Aims/hypothesisDiabetic retinopathy is a major complication of type 2 diabetes and the leading cause of blindness in adults of working age. Neuronal...
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What can we learn from animal models of convulsive status epilepticus?
Animal models of convulsive status epilepticus (SE) are essential tools for studying human SE and develo** novel therapies. Although they do not...
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Quantitative RT-PCR analyses of five evolutionary conserved genes in Alligator brains during development
Gene expression was investigated in the major brain subdivisions (telencephalon, diencephalon, midbrain and hindbrain) in a representative reptile, All...
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Pharmacokinetic of Antiepileptic Drugs in Patients with Hepatic or Renal Impairment
Many factors influence choice of antiepileptic drugs (AEDs), including efficacy of the drug for the indication (epilepsy, neuropathic pain, affective...
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Differential gene expression in ERα-positive and ERα-negative breast cancer cells upon leptin stimulation
In postmenopausal women, adipositas represents a serious risk factor for cancer development and progression. White adipose tissue secretes the 16 kDa...
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Effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline on the protective action of various antiepileptic drugs in the maximal electroshock-induced seizure model: a type II isobolographic analysis
The aim of this study was to characterize the interaction between 1-methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTHIQ—an endogenous...
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Probable levetiracetam-related serum alkaline phosphatase elevation
BackgroundLevetiracetam (LEV) is an antiepileptic drug with a favorable tolerability and safety profile with little or no effect on liver function.
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Clinical Management of Seizures in Newborns
Neonatal seizures can be classified as tonic, clonic, myoclonic, and subtle. A clinical diagnosis is not easy as seizures are usually subtle in...