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The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control
Acute promyelocytic leukemia (APL) is characterized by a block in myeloid cell differentiation. As a result of a chromosomal translocation in these...
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Reisebedingte Erkrankungen in Deutschland Ergebnisse der Einzelfall-Erhebungen des Robert Koch-Institutes
Persons who cross international boundaries are at increased risk of contracting infectious diseases. An analysis of the reported communicable...
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Management und Kontrolle lebensbedrohender hochkontagiöser Infektionskrankheiten
At present, the importation into Germany of life-threatening and highly contagious diseases such as pneumonic plague and Ebola is unlikely, but...
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Recent developments in the epidemiology of virus diseases and BSE
There is a continuous change in viral epidemics with respect to clinical symptoms, their duration or disappearence and the emergence of new diseases....
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Seroprevalence of dengue, chikungunya and sindbis virus infections in German aid workers
Vector-borne virus infections were studied in 670 German overseas aid workers who had spent an average of 37.7 months in tropical areas of Africa and...
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Lymphocytic choriomeningitis virus in southern France: Four case reports and a review of the literature
Infections due to choriomeningitis virus have been only infrequently reported in humans. Most cases have been diagnosed during laboratory outbreaks...
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Prevention and Treatment Recommendations for Respiratory Syncytial Virus Infection
Though 40 years have passed since its discovery, respiratory syncytial virus (RSV), one of the most ubiquitous viruses known, continues to evade most...
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Improving the prognostic value of CD4+ count using IgA and clinical signs in HIV-seropositive i.v. drug users
A population of 549 HIV-positive intravenous drug users, 140 of whom were women, recruited between June 1985 and June 1991, were studied to determine...
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Evaluation of the amplicor HCV test: Experiences after 1 year of routine use in a diagnostic laboratory
To evaluate the usefulness of a standardized commercial amplification assay for detection of hepatitis C virus (HCV) RNA, Amplicor® HCV Test (Roche),...
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Gene therapy in surgical oncology
Background: Surgery remains the only potentially curative treatment modality for the majority of patients with solid tumors. Conventional...
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Ribavirin therapy for hepatitis C infection following liver transplantation
Hepatitis C infection following orthotopic liver transplantation may lead to progressive chronic graft dysfunction. In this study, seven liver...
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Viral Encephalitis
Viral infections of the CNS are typically associated with mortality and morbidity. These infections are caused by a variety of both DNA and RNA...
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Syndromes with renal failure and shock
Renal failure occurs commonly in children with shock, coagulopathy and multi-organ failure. Successful management of these patients requires not only...
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Adverse Effects and Drug Interactions of Clinical Importance with Antiviral Drugs
Most antiviral drugs are nucleoside analogues with potential teratogenic, embryotoxic, carcinogenic and antiproliferative activities. They must be...