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Interferon-stimulated gene 15 modulates cell migration by interacting with Rac1 and contributes to lymph node metastasis of oral squamous cell carcinoma cells
In an effort to understand the underlying mechanisms of lymph node metastasis in oral squamous cell carcinoma (OSCC), through in vivo selection,...
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Progression in translational research on spinal cord injury based on microenvironment imbalance
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level and imposes a considerable burden on patients, families,...
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Application of Natural Medicinal Plants Active Ingredients in Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is the most common malignant cancer of the head and neck, with high morbidity and mortality, ranking as the sixth...
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MRE11 promotes oral cancer progression through RUNX2/CXCR4/AKT/FOXA2 signaling in a nuclease-independent manner
MRE11, the nuclease component of RAD50/MRE11/NBS1 DNA repair complex which is essential for repair of DNA double-strand-breaks in normal cells, has...
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A Fc-VEGF chimeric fusion enhances PD-L1 immunotherapy via inducing immune reprogramming and infiltration in the immunosuppressive tumor microenvironment
BackgroundImmunotherapy is an emerging cancer therapy with potential great success; however, immune checkpoint inhibitor ( e.g ., anti-PD-1) has...
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Alpha7 nicotinic acetylcholine receptor expression in Sorafenib-resistant Hepatocellular carcinoma cells
Hepatocellular carcinoma (HCC), the most prevalent kind of liver cancer, remains one of the world’s main causes of death. The alpha7 nicotinic...
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The role of lipopolysaccharides in diabetic retinopathy
Diabetes mellitus (DM) is a complex metabolic syndrome characterized by hyperglycemia. Diabetic retinopathy (DR) is the most common complication of...
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Spinal cord injury: molecular mechanisms and therapeutic interventions
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate. The challenges of SCI repair include its complex...
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Resveratrol effects in oral cancer cells: a comprehensive review
Oral cancer is a very common tumor worldwide with high incidence and mortality. The treatment of oral cancer involves surgery, radio- and...
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New insights into inflammatory osteoclast precursors as therapeutic targets for rheumatoid arthritis and periodontitis
Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases leading to increased bone resorption. Preventing this inflammatory bone...
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Danshen extract circumvents drug resistance and represses cell growth in human oral cancer cells
BackgroundDanshen is a common traditional Chinese medicine used to treat neoplastic and chronic inflammatory diseases in China. However, the effects...
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Molecular mechanisms of exercise contributing to tissue regeneration
Physical activity has been known as an essential element to promote human health for centuries. Thus, exercise intervention is encouraged to battle...
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C1GALT1 predicts poor prognosis and is a potential therapeutic target in head and neck cancer
Core 1 β1,3-galactosyltransferase (C1GALT1) controls the crucial step of GalNAc-type O-glycosylation and is overexpressed in various human...
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Behavioral training rescues motor deficits in Cyfip1 haploinsufficiency mouse model of autism spectrum disorders
Deletions in the 15q11.2 region of the human genome are associated with neurobehavioral deficits, and motor development delay, as well as in some...
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Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation
Aberrant protein glycosylation could be a distinct surface-marker of cancer cells that influences cancer progression and metastasis because...
