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Decompression for lumbar spinal stenosis at the intrathecal catheter insertion site during intrathecal baclofen therapy: a case report
BackgroundIntrathecal baclofen therapy can substantially improve symptoms in most patients with severe spasticity due to traumatic spinal cord...
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Early Experiences with Intrathecal Administration of Amphotericin B Liposomal Formulation at a Neurosurgical Center
BackgroundIntrathecal administration of amphotericin B represents an important adjunctive therapy for management of severe fungal meningitis....
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Prospective T1 map** to assess gadolinium retention in brain after intrathecal gadobutrol
PurposeA possible pathway behind gadolinium retention in brain is leakage of contrast agents from blood to cerebrospinal fluid and entry into brain...
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Monkeypox virus-associated meningoencephalitis diagnosed by detection of intrathecal antibody production
BackgroundIn the 2022 mpox-outbreak most patients presented with mild symptoms. Central nervous system (CNS) involvement has previously been...
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Accidental intrathecal injection of tranexamic acid: a case report
BackgroundTranexamic acid is a well-known antifibrinolytic medication frequently prescribed to individuals with bleeding disorders. Following...
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Evaluation of adding magnesium sulphate to intrathecal bupivacaine in lower limb orthopedic surgery
BackgroundA subarachnoid block is the cheaper and widely used regional block for lower limb surgery. Postoperative pain occurs after lower limb...
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Spinal adhesive arachnoiditis in an adult patient with spinal muscular atrophy type 3 treated with intrathecal therapy
BackgroundSpinal adhesive arachnoiditis is a chronic inflammatory process of the leptomeninges and intrathecal neural elements. The possible causes...
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Comparison of the effect of dexmedetomidine intrathecal injection and intravenous infusion on subarachnoid blockade during knee arthroscopy procedures: a randomized controlled trial
BackgroundComparison of whether intrathecal dexmedetomidine prolongs spinal anesthesia-associated sensorimotor blockade more than intravenous...
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Intrathecal magnesium delivery for Mg++-insensitive NMDA receptor activity due to GRIN1 mutation
BackgroundMutations in the NMDA receptor are known to disrupt glutamatergic signaling crucial for early neurodevelopment, often leading to severe...
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Refractory Cancer Pain and Intrathecal Therapy: Critical Review of a Systematic Review
This critical review assessed the advantages of invasive procedures that were recently included in systematic reviews, to evaluate whether the...
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Intrathecal chemotherapy for leptomeningeal disease in high-grade gliomas: a systematic review
BackgroundLeptomeningeal disease (LMD) secondary to high grade glioma (HGG), such as glioblastoma (GBM), are characterized by the spread of tumor...
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Iatrogenic lumbosacral infiltration with petroleum (hydrodesulfurized heavy) with secondary intrathecal distribution—a case report
Petroleum is commonly used as a solvent, and primary intrathecal administration or secondary diffusion and subsequent clinical management has not...
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Current Review of the Use of Intrathecal Morphine for Postoperative Analgesia in Total Joint Arthroplasty
Purpose of ReviewThe use of neuraxial opioids (NAO) as a method for postoperative analgesia for patients undergoing total joint arthroplasty (TJA) is...
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Intrathecal Pump Drug Delivery
This book is a comprehensive guide to Targeted Drug Delivery (TDD), also known as Intrathecal Drug Delivery (IDD), and offers an overview to this...
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Effects of palliative intrathecal analgesia on patients with refractory cancer bone pain
This study examined the effects of intrathecal analgesia (ITA) using an extracorporeal pump with a subcutaneous port system in cancer patients with...
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Antibiotic therapy by intrathecal or intraventricular approach for postsurgical meningitis or ventriculitis: a systematic review and meta-analysis
ObjectiveTo systematically review the evidence for intrathecal or intraventricular plus intravenous administration of antibiotics compared with...
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Revisiting intrathecal thiotepa: Efficacy and safety in secondary CNS malignancies
Treating metastatic malignancies to the central nervous system (CNS) is challenging because many drugs cannot cross the blood-brain-barrier (BBB)....
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Intrathecal injection of methotrexate and dexamethasone for vasculitis granuloma of the fourth ventricle: a case report and literature review
Granulomatosis with polyangiitis (GPA) is a pauci-immune small vessel vasculitis characterised by neutrophil-mediated vasculitis and granuloma. The...
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Intrathecal morphine delivery at prepontine cistern to control refractory cancer-related pain: a case report of extensive metastatic and refractory cancer pain
BackgroundExtensive metastatic and refractory cancer pain is common, and exhibits a dissatisfactory response to the conventional intrathecal infusion...
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The potent analgesia of intrathecal 2R, 6R-HNK via TRPA1 inhibition in LF-PENS-induced chronic primary pain model
BackgroundChronic primary pain (CPP) is an intractable pain of unknown cause with significant emotional distress and/or dysfunction that is a leading...
