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Ezabenlimab (BI 754091), an anti-PD-1 antibody, in patients with advanced solid tumours
BackgroundEzabenlimab (BI 754091) is a humanised monoclonal antibody targeting programmed cell death protein-1. We report results from open-label,...
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Phase I study of the VEGF/Ang-2 inhibitor BI 836880 alone or combined with the anti-programmed cell death protein-1 antibody ezabenlimab in Japanese patients with advanced solid tumors
PurposeThis two-part, open-label, non-randomized dose-escalation study aimed to define the maximum tolerated dose (MTD) of BI 836880 (humanized...
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A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease
Purpose of ReviewMajor Depressive Disorder (MDD) is characterized by persistent symptoms such as fatigue, loss of interest in activities, feelings of...
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Safety, tolerability, pharmacokinetics and pharmacodynamics of single oral doses of BI 187004, an inhibitor of 11beta-hydroxysteroid dehydrogenase-1, in healthy male volunteers with overweight or obesity
BackgroundThe study characterizes safety, tolerability, pharmacokinetic and pharmacodynamic profiles of single rising doses of the...
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Insulin Rescued MCP-1-Suppressed Cholesterol Efflux to Large HDL2 Particles via ABCA1, ABCG1, SR-BI and PI3K/Akt Activation in Adipocytes
PurposeIntracellular cholesterol imbalance plays an important role in adipocyte dysfunction of obesity. However, it is unclear whether obesity...
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DNA-PKcs promotes cardiac ischemia reperfusion injury through mitigating BI-1-governed mitochondrial homeostasis
DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel inducer to promote mitochondrial apoptosis and suppress tumor growth in a...
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The Role of Elastography in Reducing Unnecessary Biopsies in BI-RADS 4a and 4b Breast Lesions
Many benign breast lesions in the Breast Imaging Reporting and Data System (BI-RADS) 4 category defined by ultrasonography (US) undergo unnecessary...
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A polo-like kinase 1 inhibitor enhances erastin sensitivity in head and neck squamous cell carcinoma cells in vitro
BackgroundPolo-like kinase 1 (PLK1) is a critical therapeutic target in the treatment of head and neck squamous cell carcinoma (HNSCC). The objective...
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The effectiveness of a brief intervention for intensive care unit patients with hazardous alcohol use: a randomized controlled trial
BackgroundScreening for hazardous alcohol use and performing brief interventions (BIs) are recommended to reduce alcohol-related negative health...
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Breast lesions on MRI in mass and non-mass enhancement: Kaiser score and modified Kaiser score + for readers of variable experience
ObjectivesTo compare the diagnostic performance of three readers using BI-RADS and Kaiser score (KS) based on mass and non-mass enhancement (NME)...
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Open questions on basal insulin therapy in T2D: a Delphi consensus
AimsThe revolution in the therapeutic approach to type 2 diabetes (T2D) requires a rethinking of the positioning of basal insulin (BI) therapy. Given...
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Preclinical evaluation of the VEGF/Ang2 bispecific nanobody BI 836880 in nasopharyngeal carcinoma models
Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) is endemic to parts of Asia and overexpression of vascular endothelial growth...
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Effects of Single and Multiple Ascending Doses of BI 1358894 in Healthy Male Volunteers on Safety, Tolerability and Pharmacokinetics: Two Phase I Partially Randomised Studies
IntroductionThe transient receptor potential canonical (TRPC) ion channels have been implicated in the pathophysiology of major depressive disorder...
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Correlates of breakthrough COVID-19 in vaccinated patients with systemic sclerosis: survival analysis from a multicentre international patient-reported survey
This study aimed to assess the incidence, predictors, and outcomes of breakthrough infection (BI) following coronavirus disease (COVID-19)...
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Mammographic calcifications undergoing percutaneous biopsy: outcome in women with and without a personal history of breast cancer
PurposeTo compare the positive predictive values (PPVs) of BI-RADS categories used to assess pure mammographic calcifications in women with and...
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Biomechanical Integrity Score of the Female Pelvic Floor for Stress Urinary Incontinence
Introduction and hypothesisThis study is aimed at develo** and validating a new integral parameter, the Biomechanical Integrity score (BI-score) of...
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Breast Cancer Screening and BI-RADS Scoring Trends Before and During the COVID-19 Pandemic in an Academic Safety-Net Hospital
BackgroundLittle is known about how the COVID-19 pandemic affected screening mammography rates and Breast Imaging Reporting and Data Systems...
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An RBD bispecific antibody effectively neutralizes a SARS-CoV-2 Omicron variant
Potent neutralizing antibodies (nAbs) against SARS-CoV-2 are a promising therapeutic against the ongoing COVID-19 pandemic. However, the continuous...
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Characteristics and evaluation of C1 posterior arch variation for transpedicular screw placement between patients with and without basilar invagination
BackgroundC1 transpedicular screw (C1TS) placement provided satisfactory pullout resistance and 3D stability, but its application might be limited in...
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A Multicenter, Phase II Trial of Schedule Modification for Nab-Paclitaxel in Combination with Ramucirumab for Patients with Previously Treated Advanced Gastric or Gastroesophageal Junction Cancer: The B-RAX Trial (JACCRO GC-09)
BackgroundThis study investigated whether schedule modification of bi-weekly nanoparticle albumin-bound paclitaxel (nab-PTX) plus ramucirumab (RAM)...
