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Mining the interpretable prognostic features from pathological image of intrahepatic cholangiocarcinoma using multi-modal deep learning
BackgroundThe advances in deep learning-based pathological image analysis have invoked tremendous insights into cancer prognostication. Still, lack...
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Clinical and genetic analysis of Niemann-Pick disease type C with a novel NPC1 variant
BackgroundNiemann-Pick disease type C poses a significant challenge within the landscape of rare genetic disorders, marked by its connection to...
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A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori
Helicobacter pylori ( H. pylori ) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high...
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Health outcomes and healthcare utilization associated with four undiagnosed chronic conditions: evidence from nationally representative survey data in Sri Lanka
BackgroundLow awareness of chronic conditions raises the risk of poorer health outcomes and may result in healthcare utilization and spending in...
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Effect of combined physical–cognitive training on the functional and cognitive capacity of older people with mild cognitive impairment: a randomized controlled trial
BackgroundThe increase in population aging highlights the growing prevalence of mild cognitive impairment, prompting the adoption of interventions...
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A longitudinal multi-centric cohort study assessing infant neurodevelopment delay among women with persistent postpartum depression in Nepal
BackgroundInfant neurodevelopment in the first years after birth is determined by multiple factors, including parental care and maternal mental...
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Diffuse pulmonary arteriovenous malformation presenting with secondary polycythemia and headaches: a case report
BackgroundPulmonary arteriovenous malformations are a relatively uncommon medical condition, affecting roughly 1 in every 2500 individuals. Of those...
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Breaking down barriers: rationalisations and motivation to stop among Chinese male smokers under cigarette dependence
BackgroundSmoking rationalisation beliefs are a huge barrier to quitting smoking. What types of rationalisations should be emphasised in smoking...
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Contact-force local impedance algorithm to guide effective pulmonary vein isolation in AF patients: 1-year outcome from an international multicenter clinical setting
BackgroundThe combination of highly localized impedance (LI) and contact force (CF) may improve tissue characterization and lesion prediction during...
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Global incidence and characteristics of spinal cord injury since 2000–2021: a systematic review and meta-analysis
BackgroundThis study employs systematic review and meta-analysis to explore the incidence and characteristics of spinal cord injury (SCI) between...
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Vaginal and rectal microbiome contribute to genital inflammation in chronic pelvic pain
BackgroundChronic pelvic pain (CPP) is a multifactorial syndrome that can substantially affect a patient’s quality of life. Endometriosis is one...
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Surviving laryngotracheal mucormycosis: conquering central airway challenges
Laryngotracheal mucormycosis presents a rare but critical challenge, particularly in immunocompromised individuals. This report details the case of a...
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Neonatal dysglycemia: a review of dysglycemia in relation to brain health and neurodevelopmental outcomes
AbstractNeonatal dysglycemia has been a longstanding interest of research in neonatology. Adverse outcomes from hypoglycemia were recognized early...
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Epidemic modelling suggests that in specific circumstances masks may become more effective when fewer contacts wear them
BackgroundThe effectiveness of non-pharmaceutical interventions to control the spread of SARS-CoV-2 depends on many contextual factors, including...
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Novel genomic variants related to visceral adiposity index (VAI) and body adiposity index (BAI) in Indian sib-pairs
BackgroundObesity is among the leading public health threats globally. Over the last few years, visceral adiposity index (VAI), and body adiposity...
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An unexpected case of an adnexal hydatid cyst in a pregnant woman: a case report
BackgroundCystic echinococcosis, also known as hydatid disease, is a chronic and endemic illness caused by infection with a parasite called Echinococc...
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Work ability and return-to-work of patients with post-COVID-19: a systematic review and meta-analysis
BackgroundIn addition to several sequelae of post-COVID-19, individuals also experience significant limitations in work ability, resulting in...
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Unified metagenomic method for rapid detection of microorganisms in clinical samples
BackgroundClinical metagenomics involves the genomic sequencing of all microorganisms in clinical samples ideally after depletion of human DNA to...
