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More efficient adaptation of cardiovascular response to repeated restraint in spontaneously hypertensive rats: the role of autonomic nervous system
We hypothesized that sympathetic hyperactivity and parasympathetic insuficiency in spontaneously hypertensive rats (SHR) underlie their exaggerated...
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Some Perceptions Differ, Match Outcomes Do Not: A Multisite Retrospective Cross-Sectional Comparison of Virtual vs. In-Person Recruitment
BackgroundVirtual interviewing for residency provides considerable savings. Its impact on match outcomes remains unclear.
ObjectiveEvaluate the...
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B cell lymphoma 6 promotes hepatocellular carcinoma progression by inhibiting tumor infiltrating CD4+T cell cytotoxicity through ESM1
Immunotherapy exhibited potential effects for advanced hepatocellular carcinoma, unfortunately, the clinical benefits are often countered by cancer...
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Revisiting the role of mesenchymal stromal cells in cancer initiation, metastasis and immunosuppression
Immune checkpoint blockade (ICB) necessitates a thorough understanding of intricate cellular interactions within the tumor microenvironment (TME)....
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Resolution of extravascular hemolysis with oral iptacopan monotherapy in a patient with treatment experienced paroxysmal nocturnal hemoglobinuria (PNH)
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematologic disorder characterized by a loss of glycosyl-phosphatidyl-inositol-linked (GPI)...
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Mental health outcomes of offspring exposed to parental intimate partner violence in Rwanda
BackgroundChildren who witness parental intimate partner violence (IPV) are more likely to develop mental health issues compared to those who do not...
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Knowledge of hepatitis B infection, hepatitis B vaccine, and vaccination status with its associated factors among healthcare workers in Kampot and Kep Provinces, Cambodia
BackgroundHealthcare Workers (HCWs) are susceptible to hepatitis B virus (HBV) infection and are advised to receive vaccination. However, vaccination...
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Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions
The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial...
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Progression of brain injuries associated with methotrexate chemotherapy in childhood acute lymphoblastic leukemia
BackgroundBrain bases and progression of methotrexate-associated neurotoxicity and cognitive disturbances remain unknown. We tested whether brain...
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Evaluation of nanocellulose-based anthraquinone from marine fungi Penicillium flavidorsum as an alternative therapy for skin wound healing: histopathological and immunohistochemical evidences from a rat model
BackgroundWound healing represents a complex clinical challenge, necessitating the selection of appropriate wound dressings to facilitate an...
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Develo** inclusive public involvement and engagement activities with secondary school students and educational professionals: a protocol
BackgroundPublic involvement and engagement (PI&E) is increasingly recognised as an important component of research. It can offer valuable insights...
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Antibody–Drug Conjugates in the Pipeline for Treatment of Melanoma: Target and Pharmacokinetic Considerations
Melanoma is an aggressive, rapidly develo** form of skin cancer that affects about 22 per 100,000 individuals. Treatment options for melanoma...
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Pulmonary embolism in patients with chronic coronary syndrome masquerading as acute coronary syndrome: a case report and literature review
BackgroundPulmonary embolisms (PEs) exhibit clinical features similar to those of acute coronary syndrome (ACS), including electrocardiographic...
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Classification of the oesophageal perforation
ObjectivesEsophageal perforations are a complex clinical scenario that have been poorly studied. To date, there is no grading of esophageal...
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Psychological Distress in the Era of Psychological Safety
There has been a growing disconnect between learners and educators within medical education. As the landscape of medical education has been altered...
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The role of histamine and its receptors in breast cancer: from pathology to therapeutic targets
Breast cancer is the most common malignancy in women, and despite the development of new treatment methods and the decreasing mortality rate in...
