Search
Search Results
-
Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
SF3B1 mutations frequently occur in cancer yet lack targeted therapies. Clinical trials of XPO1 inhibitors, selinexor and eltanexor, in high-risk...
-
-
Rare tumours of the pancreas: monocentric study
PurposeThe biology of rare pancreatic tumours, which differs from that of ductal pancreatic cancer, requires increased attention. Although the...
-
Re-administration of platinum-based chemotherapy for recurrent endometrial cancer: an ancillary analysis of the SGSG-012/GOTIC-004/Intergroup study
BackgroundWe previously demonstrated the applicability of the concept of “platinum sensitivity” in recurrent endometrial cancer. Although immune...
-
Targeting CD73 limits tumor progression and enhances anti-tumor activity of anti-PD-1 therapy in intrahepatic cholangiocarcinoma
Background & aimsPatients with intrahepatic cholangiocarcinoma (iCCA) respond poorly to immune checkpoint blockades (ICBs). In this study, we aimed...
-
Multimodal training protocols on unstable rather than stable surfaces better improve dynamic balance ability in older adults
BackgroundThere has been growing interest in using unstable devices in training protocols. This study aimed to assess the effectiveness of two...
-
Hepatocellular Carcinoma in Asia: Physician and Patient Perspectives on Surveillance, Diagnosis, and Treatment
PurposeIn several Asian countries, hepatocellular carcinoma (HCC) is a leading cause of cancer deaths. HCC risk factors in Asia differ from those...
-
Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases
Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether...
-
CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy
NKT cells, unique lymphocytes bridging innate and adaptive immunity, offer significant potential for managing inflammatory disorders like asthma....
-
An analysis of the role of GAB2 in pan-cancer from a multidimensional perspective
BackgroundTo explore the role of GAB2 in pan-cancer based on bioinformatics analysis.
MethodsBased on TCGA and GTEx databases, we used TIMER2.0...
-
Patientenbefragung zum Einsatz von Videosprechstunden in der ambulanten Behandlung von chronischem Pruritus
BackgroundAnalyses of patient evaluations and barriers to the implementation of teledermatology procedures are still rare. The aim of this study was...
-
The diagnostic and prognostic value of tartrate-resistant acid phosphatase isoform 5b for giant cell tumor of bone
BackgroundSerum level of tartrate-resistant acid phosphatase 5b (TRACP5b) is an excellent serum marker of bone resorption. In patients with giant...
-
Neues in der Diagnostik und Therapie der aktinischen Keratose
Actinic keratosis (AK) is among the most common conditions in dermatology in an increasingly aging population. However, the presence of severe field...
-
MICAL1 promotes the proliferation in acute myeloid leukemia and is associated with clinical prognosis and immune infiltration
Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies that has a poor prognosis and a high rate of relapse. Dysregulated...
-
-
Biliary atresia
Biliary atresia (BA) is a progressive inflammatory fibrosclerosing disease of the biliary system and a major cause of neonatal cholestasis. It...
-
Budesonide in Liver Immunology: A Therapeutic Opportunity in Liver Transplantation
Purpose of ReviewA major remaining challenge in liver transplantation is achieving the balance between adequate immunosuppression to prevent...
-
A systematic review on the effectiveness of robot-assisted minimally invasive gastrectomy
BackgroundRobot-assisted minimally invasive gastrectomy (RAMIG) is increasingly used as a surgical approach for gastric cancer. This study assessed...
-
A joint model of longitudinal pharmacokinetic and time-to-event data to study exposure–response relationships: a proof-of-concept study with alectinib
PurposeIn exposure–response analyses of oral targeted anticancer agents, longitudinal plasma trough concentrations are often aggregated into a single...
-
