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Construction and validation of a risk prediction model for postoperative ICU admission in patients with colorectal cancer: clinical prediction model study
BackgroundTransfer to the ICU is common following non-cardiac surgeries, including radical colorectal cancer (CRC) resection. Understanding the...
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Urinary metabolomics signature of animal and plant protein intake and its association with 24-h blood pressure: the African-PREDICT study
The contrasting relationships of plant and animal protein intake with blood pressure (BP) may be partially attributed to the differential non-protein...
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Comparison of different concentrations of ropivacaine in epidural anesthesia for percutaneous transforaminal endoscopic discectomy: a randomized controlled trial
BackgroundThis study investigated the optimal concentration of ropivacaine epidural anesthesia for clinical use in percutaneous transforaminal...
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Prognostic Implications of Coronary Artery Sclerosis in Troponin-Positive Patients with Non-Obstructive Coronary Arteries
IntroductionCoronary sclerosis is a risk factor for the progression to obstructive coronary artery disease (CAD). However, understanding its impact...
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Frontiers in Acute Pain Management: Emerging Concepts in Pain Pathways and the Role of VX-548 as a Novel NaV1.8 Inhibitor: A Narrative Review
Purpose of ReviewDespite ongoing research into alternative postsurgical pain treatments, opioids remain widely used analgesics regardless of...
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Diagnostic and therapeutic delays in lung cancer during the COVID-19 pandemic: a single center experience at a German Cancer center
BackgroundThe COVID-19 pandemic has had negative drawbacks on the healthcare system worldwide and on individuals other than those directly affected...
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Bioelectrical impedance and lung function—associations with gender and central obesity: results of the EpiHealth study
BackgroundObesity is a major public health concern associated with various health problems, including respiratory impairment. Bioelectrical impedance...
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Immune checkpoint inhibitor-associated new-onset hypophysitis: a retrospective analysis using the FAERS
BackgroundOur study aimed to investigate the prevalence and demographic characteristics of immune checkpoint inhibitor-associated hypophysitis...
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Diagnostic accuracy of the Xpert® MTB/XDR assay for detection of Isoniazid and second-line antituberculosis drugs resistance at central TB reference laboratory in Tanzania
IntroductionEarly diagnosis of tuberculosis (TB) and universal access to drug-susceptibility testing (DST) are critical elements of the WHO End TB...
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A “Prime and Expand” strategy using the multifunctional fusion proteins to generate memory-like NK cells for cell therapy
Adoptive cellular therapy (ACT) using memory-like (ML) natural killer (NK) cells, generated through overnight ex vivo activation with IL-12, IL-15,...
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Pyroptosis-related long-noncoding RNA signature predicting survival and immunotherapy efficacy in patients with lung squamous cell carcinoma
Pyroptosis-related long-noncoding RNAs (PRlncRNAs) play an important role in cancer progression. However, their role in lung squamous cell carcinoma...
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Timely initiation of complementary feeding and associated factors among mothers having children aged 6 to 24 months in North-West Ethiopia: a comparative cross-sectional study
BackgroundThe timely introduction of complementary foods during infancy is necessary for nutritional reasons, and to enable the transition from milk...
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Progressive encephalomyelitis with rigidity and myoclonus: a pediatric case report and literature review
BackgroundProgressive encephalomyelitis with rigidity and myoclonus (PERM) is a rare and life-threatening autoimmune disease of the central nervous...
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Conservative Management of Occipital Neuralgia Supported by Physical Therapy: A Review of Available Research and Mechanistic Rationale to Guide Treatment
Purpose of ReviewConservative management is consistently recommended as a first line intervention for occipital neuralgia (ON); however, there is...
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Radiopalmar ganglion cysts: prevalence, morphology, and clinical significance in wrist MRI
ObjectivesTo assess radiopalmar ganglion cysts’ (RPG) prevalence, morphology, and clinical significance in consecutive patients.
Materials and methods ...
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Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression
More than 90% of hepatocellular carcinoma (HCC) cases develop in the presence of fibrosis or cirrhosis, making the tumor microenvironment (TME) of...
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Prolonged water-only fasting in the management of low-grade follicular lymphoma: a case series
BackgroundFollicular lymphoma typically follows an indolent and relapsing course often requiring several treatment cycles to achieve remission. Some...
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Insomnia During Late Life: Potential Pathways Toward Suicide Risk
Purpose of ReviewAs the global population continues to age, the identification of drivers of suicide risk in older adults is of increasing...
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Drug-related emergency department visits: external validation of an assessment tool in a general emergency department population
BackgroundThe process of identifying drug-related hospitalisations is subjective and time-consuming. Assessment tool for identifying hospital...
