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Vitamin D, chronic pain, and depression: linear and non-linear Mendelian randomization analyses
Vitamin D deficiency has been linked to various chronic pain conditions. However, randomized trials of vitamin D supplementation have had mixed...
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Epigenetic signals associated with delirium replicated across four independent cohorts
Delirium is risky and indicates poor outcomes for patients. Therefore, it is crucial to create an effective delirium detection method. However, the...
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Gestational valproic acid exposure enhances facial stimulation-evoked cerebellar mossy fiber-granule cell transmission via GluN2A subunit-containing NMDA receptor in offspring mice
Valproic acid (VPA) is one of the most effective antiepileptic drugs, and exposing animals to VPA during gestation has been used as a model for...
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Influenza A virus during pregnancy disrupts maternal intestinal immunity and fetal cortical development in a dose- and time-dependent manner
Epidemiological studies link exposure to viral infection during pregnancy, including influenza A virus (IAV) infection, with increased incidence of...
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Genetic analyses point to alterations in immune-related pathways underpinning the association between psychiatric disorders and COVID-19
Current literature suggests that people with psychiatric disorders have a higher risk of COVID-19 infection and a worse prognosis of the disease. We...
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Neuroglia in cognitive reserve
The concept of cognitive reserve was born to account for the disjunction between the objective extent of brain damage in pathology and its clinical...
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A discrete subpopulation of PFC-LHb neurons govern cocaine place preference
Addiction is a complex behavioral disorder characterized by compulsive drug-seeking and drug use despite harmful consequences. The prefrontal cortex...
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Factors underlying the neurofunctional domains of the Addictions Neuroclinical Assessment assessed by a standardized neurocognitive battery
The Addictions Neuroclinical Assessment (ANA) is a neurobiologically-informed framework designed to understand the etiology and heterogeneity of...
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The impact of REM sleep loss on human brain connectivity
Brain function is vulnerable to the consequences of inadequate sleep, an adverse trend that is increasingly prevalent. The REM sleep phase has been...
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Coupled changes between ruminating thoughts and resting-state brain networks during the transition into adulthood
Perseverative negative thoughts, known as rumination, might arise from emotional challenges and preclude mental health when transitioning into...
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Breakthroughs and challenges for generating brain network-based biomarkers of treatment response in depression
Treatment outcomes widely vary for individuals diagnosed with major depressive disorder, implicating a need for deeper understanding of the...
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Distinct synaptic mechanisms drive the behavioral response to acute stress and rapid correction by ketamine
Prevailing hypotheses on the mechanisms of antidepressant action posit that antidepressants directly counteract deficiencies in major...
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Interaction of perceived social support and childhood maltreatment on limbic responsivity towards negative emotional stimuli in healthy individuals
Childhood maltreatment (CM) is associated with increased limbic activity, while social support is linked to decreased limbic activity towards...
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Identification of novel genetic loci and candidate genes for progressive ethanol consumption in diversity outbred mice
Mouse behavioral genetic map** studies can identify genomic intervals modulating complex traits under well-controlled environmental conditions and...
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Dynamicity of brain network organization & their community architecture as characterizing features for classification of common mental disorders from whole-brain connectome
The urgency of addressing common mental disorders (bipolar disorder, attention-deficit hyperactivity disorder (ADHD), and schizophrenia) arises from...
