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Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases
Proteolytic cell surface release (‘shedding’) of the prion protein (PrP), a broadly expressed GPI-anchored glycoprotein, by the metalloprotease...
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Neural correlates of depression-related smartphone language use in adolescents
Magnetic resonance imaging has provided pathophysiological insights into adolescent depression but is a relatively inaccessible technology....
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Self-expanding intracranial drug-eluting stent system in patients with symptomatic intracranial atherosclerotic stenosis: initial experience and midterm angiographic follow-up
BackgroundSymptomatic intracranial atherosclerotic stenosis (ICAS) is a major cause of ischemic stroke worldwide. In patients undergoing endovascular...
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Defining tumor growth in vestibular schwannomas: a volumetric inter-observer variability study in contrast-enhanced T1-weighted MRI
PurposeFor patients with vestibular schwannomas (VS), a conservative observational approach is increasingly used. Therefore, the need for accurate...
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Impairment of the GABAergic system in the anterior insular cortex of heroin-addicted males
Opioid addiction is a global problem, causing the greatest health burden among drug use disorders, with opioid overdose deaths top** the statistics...
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Impact of post-thrombectomy isolated subarachnoid hemorrhage on neurological outcomes in patients with anterior ischemic stroke – a retrospective single-center observational study
PurposeWe aimed to investigate the impact of post-thrombectomy isolated subarachnoid hemorrhage (i-SAH) and other types of intracranial hemorrhage...
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Strength in silence: the journey of mothers raising children with hydrocephalus
BackgroundRaising a child with hydrocephalus can be very challenging, especially in low- and middle-income countries. In Pakistan, mothers being the...
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Dimethyl fumarate preserves brainstem and cervical spinal cord integrity in radiologically isolated syndrome
Background and PurposeThe first randomized placebo-controlled therapeutic trial in radiologically isolated syndrome (RIS), ARISE, demonstrated that...
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Resolution of anti-LGI1-associated autoimmune encephalitis in a patient after treatment with efgartigimod
BackgroundAnti leucine-rich, glioma inactivated 1 (LGI1) antibody-associated autoimmune encephalitis (AE) is the second most common AE, where the...
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Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status
This study investigates various pathological tau isoforms in the retina of individuals with early and advanced Alzheimer’s disease (AD), exploring...
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Serum dysregulation of serine and glycine metabolism as predictive biomarker for cognitive decline in frail elderly subjects
Frailty is a common age-related clinical syndrome characterized by a decline in the function of multiple organ systems, increased vulnerability to...
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DNA methylation profiles of cancer-related fatigue associated with markers of inflammation and immunometabolism
Cancer patients are commonly affected by fatigue. Herein, we sought to examine epigenetic modifications (i.e., DNA methylation) related to fatigue in...
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Brain Networks, Neurotransmitters and Psychedelics: Towards a Neurochemistry of Self-Awareness
Purpose of ReviewSelf-awareness can be defined as the capacity of becoming the object of one’s own awareness and, increasingly, it has been the...
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Terminologia Anatomica 2nd edition: perspectives from anatomy educators in the United Kingdom
English anatomical terminology has evolved over the long history of anatomical practice, with major influences from ancient Greek, classical Latin,...
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Distribution pattern of the celiac, cranial mesenteric, and caudal mesenteric arteries to the gastrointestinal tract in the common marmoset (Callithrix jacchus)
Gastrointestinal diseases pose problems to captive common marmosets. Therefore, knowledge of the anatomy of the arterial supply to the...
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Cognition and Activity of Daily Living Function in people with Parkinson’s disease
The ability to perform activities of daily living (ADL) function is a multifaceted construct that reflects functionality in different daily life...
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Modulation of dlPFC function and decision-making capacity by repetitive transcranial magnetic stimulation in methamphetamine use disorder
This study explores the impact of repetitive transcranial magnetic stimulation (rTMS) on decision-making capabilities in individuals with...
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Neurosteroids and translocator protein 18 kDa (TSPO) ligands as novel treatment options in depression
Recently, the gamma-aminobutyric acid (GABA) system has come into focus for the treatment of anxiety, postpartum depression, and major depressive...
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TREK-1 channel as a therapeutic target for dexmedetomidine-mediated neuroprotection in cerebral ischemia
Our objective is to explore the protective effect of Dexmedetomidine on brain apoptosis and its mechanism through TREK-1 pathway. Forty male...
