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PET imaging of neuroinflammation: any credible alternatives to TSPO yet?
Over the last decades, the role of neuroinflammation in neuropsychiatric conditions has attracted an exponentially growing interest. A key driver for...
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A bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior
The single nucleotide polymorphism rs13166360, causing a substitution of valine (Val) 147 to leucine (Leu) in the adenylyl cyclase 2 (ADCY2), has...
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RET Inhibitors in RET Fusion-Positive Lung Cancers: Past, Present, and Future
While activating RET fusions are identified in various cancers, lung cancer represents the most common RET fusion-positive tumor. The clinical drug...
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Targeting DNA Damage Response Deficiency in Thoracic Cancers
Thoracic cancers comprise non-small cell lung cancers (NSCLCs), small cell lung cancers (SCLCs) and malignant pleural mesotheliomas (MPM)....
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Multimodal training protocols on unstable rather than stable surfaces better improve dynamic balance ability in older adults
BackgroundThere has been growing interest in using unstable devices in training protocols. This study aimed to assess the effectiveness of two...
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Estrogen receptor beta signaling enhances extinction memory recall for heroin-conditioned cues in a sex- and region-specific manner
Return to use, or relapse, is a major challenge in the treatment of opioid use disorder (OUD). Relapse can be precipitated by several factors,...
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Trauma, adversity, and biological aging: behavioral mechanisms relevant to treatment and theory
Although stress and adversity are largely universal experiences, people exposed to greater hardship are at increased risk for negative health...
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Sleep profiles of different psychiatric traits
Disturbed sleep comes in many forms. While the key role of sleep in mental health is undisputed, our understanding of the type of slee** problems...
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Machine Learning Approach in Dosage Individualization of Isoniazid for Tuberculosis
IntroductionIsoniazid is a first-line antituberculosis agent with high variability, which would profit from individualized dosing. Concentrations of...
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Patterns of Pregabalin Users from Substance Abuse Treatment Facilities: Results from the French OPPIDUM Program from 2008 to 2022
IntroductionIn recent years, pregabalin has received growing attention due to its abuse liability. The aim of this study was to further characterize...
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Leveraging continuous glucose monitoring as a catalyst for behaviour change: a sco** review
BackgroundAmidst the escalating prevalence of glucose-related chronic diseases, the advancements, potential uses, and growing accessibility of...
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The Association of Gabapentin Initiation with Cognitive and Behavioral Changes in Older Adults with Cognitive Impairment: A Retrospective Cohort Study
BackgroundAlthough gabapentin has been increasingly prescribed to older adults, the relation between gabapentin initiation and longer-term...
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Behaviour change interventions to improve physical activity in adults: a systematic review of economic evaluations
BackgroundBehaviour change interventions can result in lasting improvements in physical activity (PA). A broad implementation of behaviour change...
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Lichen Planus: What is New in Diagnosis and Treatment?
Lichen planus (LP), an idiopathic, multifaceted chronic inflammatory disease with a heterogeneous clinical presentation, affects approximately 0.5–1%...
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Pre-clinical Models for Geriatric Pharmacotherapy
With ageing of the population worldwide and discovery of new medications for prevention and management of age-related conditions, there is increasing...
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Use of Muscle Relaxants After Surgery in Traditional Medicare Part D Enrollees
BackgroundSurgeons have come under increased scrutiny for postoperative pain management, particularly for opioid prescribing. To decrease opioid use...
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Serum dysregulation of serine and glycine metabolism as predictive biomarker for cognitive decline in frail elderly subjects
Frailty is a common age-related clinical syndrome characterized by a decline in the function of multiple organ systems, increased vulnerability to...
