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An elderly case of paraneoplastic anti-NMDA receptor encephalitis associated with large cell neuroendocrine carcinoma of the lung
BackgroundRecent studies have suggested that N-methyl-D-aspartate (NMDA) receptors are involved in the cell proliferation in several tumors. However,...
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Transcriptomic Expression of T2-Inflammation Genes in Peripheral Blood Mononuclear Cells and Longitudinal Clinical Outcomes in Asthma: Insights from the COREA Study
BackgroundGene expression can provide distinct information compared to clinical biomarkers in the context of longitudinal clinical outcomes in asthma...
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Longitudinal lung function trajectories in response to azithromycin therapy for chronic lung disease in children with HIV infection: a secondary analysis of the BREATHE trial
BackgroundChronic lung disease (CLD) is common among children with HIV (CWH) including in those taking antiretroviral therapy (ART). Azithromycin has...
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Novel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods
PurposeContinuous positive airway pressure (CPAP) is the primary therapy for obstructive sleep apnea (OSA); however the effectiveness of CPAP remains...
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The utility of various predictive equations in patients with severe Obstructive Sleep Apnea: a clinical practice viewpoint in settings with limited resources
BackgroundThe continuous positive airway pressure (CPAP) needed for the treatment of obstructive sleep apnea (OSA) can be determined after a manual...
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Performing polysomnography in pre-school aged children: challenging parts of the procedure and risk factors for lead intolerance
PurposePediatric sleep apnea begins in toddlerhood when sleep is vital for neurocognitive development and rapid somatic growth. As polysomnography...
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The integrin receptor beta7 subunit mediates airway remodeling and hyperresponsiveness in allergen exposed mice
BackgroundFibroblast differentiation to a myofibroblast phenotype is a feature of airway remodeling in asthma. Lung fibroblasts express the integrin...
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Metagenomic next-generation sequencing promotes diagnosis and treatment of Pneumocystis jirovecii pneumonia in non-HIV infected children: a retrospective study
BackgroundMetagenomic next-generation sequencing (mNGS) excels in diagnosis of infection pathogens. We aimed to evaluate the performance of mNGS for...
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The Effect of Long-Term Azithromycin on Objective and Subjective Cough in Chronic Respiratory Disease: A Systematic Review and Meta-analysis of Randomised Controlled Trials and Noncomparative Studies
IntroductionAzithromycin is an effective treatment for various respiratory conditions but its effect on cough is poorly understood. We synthesised...
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Childhood asthma and mould in homes—A meta-analysis
Asthma is a multifaceted and multicausal disease. Childhood asthma is strongly influenced by genetic traits and is characterized by hyperreactivity...
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Lower or higher oxygenation targets in the intensive care unit: an individual patient data meta-analysis
PurposeOptimal oxygenation targets for patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are not clearly defined due...
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Tezepelumab for refractory eosinophilic granulomatosis with polyangiitis-related asthma
Conventional immunosuppressants are ineffective for the management of EGPA-related asthma. Tezepelumab is a human monoclonal antibody that inhibits...
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Physiologic and anatomic determinants of hyoid motion during drug-induced sleep endoscopy
PurposeTo examine factors accounting for differences in hyoid motion during obstructive breathing events amongst obstructive sleep apnea (OSA)...
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Burden of illness in patients with pulmonary hypertension due to interstitial lung disease: a real-world analysis
BackgroundPulmonary hypertension due to interstitial lung disease (PH-ILD) is associated with high rates of respiratory failure and death. Healthcare...