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Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases
Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether...
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Soft tissue hemangioma of the right upper extremity with intraosseous extension and secondary intravascular papillary endothelial hyperplasia
Intravascular papillary endothelial hyperplasia (IPEH), also known as Masson’s tumor, is an uncommon exuberant form of organizing thrombus that may...
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Combined neurokinin-1 receptor antagonist and sorafenib is a promising approach for hepatocellular carcinoma therapy
BackgroundHCC (Hepatocellular carcinoma) is the most common primary malignant cancer in the liver. Treatment options to incurable HCC such as...
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Contemporary review of papillary renal cell carcinoma—current state and future directions
Historically, papillary renal cell carcinoma (PRCC) was divided into two types, type 1 and type 2, based solely on morphology. However, it is...
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DNA methylation patterns in the frontal lobe white matter of multiple system atrophy, Parkinson’s disease, and progressive supranuclear palsy: a cross-comparative investigation
Multiple system atrophy (MSA) is a rare neurodegenerative disease characterized by neuronal loss and gliosis, with oligodendroglial cytoplasmic...
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Anti-cancer potential of casein and its derivatives: novel strategies for cancer treatment
Cancer is one of the leading causes of death worldwide, with over 10 million fatalities annually. While tumors can be surgically removed and treated...
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Pediatric thyroid-like follicular renal cell carcinoma—a post-neuroblastoma case with comprehensive genomic profiling data
Thyroid-like follicular renal cell carcinoma (TLFRCC), an emerging subtype of renal cell carcinoma, presents diagnostic challenges due to its...
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Comprehensive analysis of transcription factors involved in odontoblast differentiation mechanism
Primary cultured odontoblasts rapidly lose their tissue-specific phenotype. To identify transcription factors (TF) that are important for the...
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Immunohistochemistry staining of Eag1 and p16/Ki-67 can help improve the management of patients with cervical intraepithelial Neoplasia after cold knife conversion
BackgroundImmunohistochemistry (IHC) is widely used in the management of patients with cervical intraepithelial neoplasia (CIN) but still has many...
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Stability of new psychoactive substances in crude wastewater
Those involved in drug testing continue to grapple with the dynamic nature of emerging psychoactive substances (NPS) and their rapid infiltration...
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Dynamic ultrasound assessment for insertional achilles tendinopathy: the COcco-RIcci (CORI) sign
ObjectiveTo describe a novel, dynamic ultrasound assessment of the Achilles tendon at the calcaneal insertion taking advantage of the effusion within...
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Hepatitis B virus in Egypt: the whole story
Hepatitis B virus (HBV) infection is a significant global public health threat with variable geographical distribution. Chronic infection with HBV...
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Situs inversus partialis (levocardia): an incidental discovery of an extremely rare case during the autopsy of a female with suicidal poisoning
BackgroundSitus inversus is a rare congenital anomaly. In this condition, the abdominal and chest organs are positioned in reverse, a mirror image of...
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Prevalence of hepatitis B among pregnant women in Libreville, Gabon
BackgroundHepatitis B virus (HBV) infection is one of the major public health problems worldwide. In pregnant women, there is a risk of...
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Small molecule inhibitors of the VEGF and tyrosine kinase for the treatment of cervical cancer
Cervical cancer accounts for most deaths due to cancer in women, majorly in develo** nations. The culprit behind this disease is the human...
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Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases
Proteolytic cell surface release (‘shedding’) of the prion protein (PrP), a broadly expressed GPI-anchored glycoprotein, by the metalloprotease...
