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Stereotactic body radiation therapy for multiple lung cancers in a patient with six primary cancers: a case report
BackgroundSurgery is the standard care for patients with early-stage lung cancer, and stereotactic body radiation therapy is an option for those who...
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Sex-dependent association of serum vitamin D with muscle strength in older adults: NHANES 2001–2002
BackgroundAlthough several studies have suggested a potential positive association between serum vitamin D levels and muscle strength in older...
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A double CYP27A1 gene mutation in spinal cerebrotendinous xanthomatosis in a patient presenting with spastic gait: a case report
BackgroundCerebrotendinous xanthomatosis (CTX, OMIM #213700) is a rare inherited metabolic disease caused by the mutation in the CYP27A1 gene....
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The RNA helicases DDX19A/B modulate selinexor sensitivity by regulating MCL1 mRNA nuclear export in leukemia cells
Selinexor, a first-in-class exportin1 (XPO1) inhibitor, is an attractive anti-tumor agent because of its unique mechanisms of action; however, its...
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Central nervous system involvement in chronic lymphocytic leukemia: a case report and review of literature
BackgroundCentral nervous system involvement in chronic lymphocytic leukemia rarely occurs, and there is no standard therapy for central nervous...
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The SHOW RESPECT adaptable framework of considerations for planning how to share trial results with participants, based on qualitative findings from trial participants and site staff
BackgroundSharing trial results with participants is a moral imperative, but too often does not happen in appropriate ways.
MethodsWe carried out...
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Dietary diversity and iron deficiency anemia among a cohort of singleton pregnancies: a cross-sectional study
BackgroundIron deficiency anemia (IDA) is considered one of the most common medical disorders observed during pregnancy. In low- and middle-income...
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Effect of NLRP3 gene knockdown on pyroptosis and ferroptosis in diabetic cardiomyopathy injury
Diabetic cardiomyopathy (DCM) is a chronic disease caused by diabetes mellitus, which is recognized as a worldwide challenging disease. This study...
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Tremor as a Neuropsychiatric Manifestation of Systemic Lupus Erythematosus: A Case Report and Review of Related Literature
Movement disorders in neuropsychiatric systemic lupus erythematosus (NPSLE) are rare. Chorea remains the predominant phenomenology whereas tremors...
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Estimation of age and sex from fingernail clip**s by using ATR-FTIR spectroscopy coupled with chemometric interpretation
Fingernails can act as important forensic evidence as they can be a source of DNA that may link the victim or accused to the crime scene and may also...
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Consequences of ionizing radiation exposure to the cardiovascular system
Ionizing radiation is widely used in various industrial and medical applications, resulting in increased exposure for certain populations. Lessons...
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Cardiovascular diseases as risk factors of post-COVID syndrome: a systematic review
BackgroundA growing proportion of people experience incomplete recovery months after contracting coronavirus disease 2019 (COVID-19). These COVID-19...
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Analytical quality by design (AQbD) based optimization of RP-UPLC method for determination of nivolumab and relatlimab in bulk and pharmaceutical dosage forms
BackgroundThe Analytical Quality by Design (AQbD) methodology extends the application of Quality by Design (QbD) principles to the management of the...
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Health-related quality of life and symptoms of chronic myeloid leukemia patients after discontinuation of tyrosine kinase inhibitors: results from the EURO-SKI Trial
Limited data is available on the health-related quality of life (HRQoL) and symptoms of patients with chronic myeloid leukemia (CML) who are in...
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Urine biomarkers in type 2 diabetes mellitus with or without microvascular complications
ObjectiveTo investigate the distribution of nine (9) urine biomarkers in people living with type 2 diabetes mellitus (T2DM), with or without...
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Evidence-based Prostate Cancer Screening Interventions for Black Men: A Systematic Review
AbstractProstate cancer is the second leading cause of death for men in the U.S. and Black men are twice as likely to die from the disease. However,...
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Butyrate and tributyrin reduce LPS-induced inflammatory cytokine production from human visceral fat
IntroductionThe current obesity crisis has resulted in many people with excess adipose tissue suffering from chronic inflammation. This inflammation...
