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1. SHR-A1811 (antibody-drug conjugate) in advanced HER2-mutant non-small cell lung cancer: a multicenter, open-label, phase 1/2 study

   A dose-escalation and expansion, phase 1/2 study (ClinicalTrials.gov, NCT04818333) was conducted to assess the novel antibody-drug conjugate...

   Ziming Li, Zhengbo Song, ... Shun Lu in Signal Transduction and Targeted Therapy

   Article Open access 15 July 2024
   

2. Map** alternative splicing events in colorectal cancer

   Although aberrant splicing events of genes are closely related to the development and progression of colorectal cancer (CRC), the map** of abnormal...

   Yifeng Zheng, Guoqiang Zhong, ... Mingsong Li in Discover Oncology

   Article Open access 15 July 2024
   

3. Mavorixafor: First Approval

   Mavorixafor (XOLREMDI™) is an oral, selective C-X-C chemokine receptor 4 (CXCR4) antagonist developed by X4 Pharmaceuticals that blocks the binding...

   Sheridan M. Hoy in Drugs

   Article 15 July 2024
   

4. Detection and characterization of autoreactive memory stem T-cells in children with acute immune thrombocytopenia

   Primary immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by an isolated decrease in platelets below 100 × 10 ⁹ /l after...

   Asmaa M. Zahran, Omnia H. El-Badawy, ... Khalid I. Elsayh in Clinical and Experimental Medicine

   Article Open access 15 July 2024
   

5. Efficacy and Safety of Salvage-line Nivolumab Monotherapy for Advanced Esophageal Squamous Cell Carcinoma: Comparison of 240 mg Versus 480 mg Doses

   Background

   Nivolumab monotherapy is the standard second-line treatment for advanced esophageal squamous cell carcinoma (ESCC) after failure of...

   Yuko Murashima, Shun Yamamoto, ... Ken Kato in Journal of Gastrointestinal Cancer

   Article Open access 15 July 2024
   

6. Evaluating [²²⁵Ac]Ac-FAPI-46 for the treatment of soft-tissue sarcoma in mice

   Purpose

   Fibroblast Activation Protein (FAP) is an emerging theranostic target that is highly expressed on cancer-associated fibroblasts and on certain...

   Marco F. Taddio, Suraj Doshi, ... Christine E. Mona in European Journal of Nuclear Medicine and Molecular Imaging

   Article Open access 15 July 2024
   

7. Disclosing tumor biology by means of molecular imaging in a patient with malignant melanoma and chronic lymphatic leukemia

   Alexander Gäble, Johanna S. Enke, ... Malte Kircher in European Journal of Nuclear Medicine and Molecular Imaging

   Article Open access 15 July 2024
   

8. Effect of dorsal capsular imbrication on intraoperative DRUJ instability following arthroscopic TFCC repair surgery

   Background

   To assess the clinical outcomes and identify the ideal indication for implementing dorsal distal radioulnar joint (DRUJ) capsular...

   Chen-Wei Yeh, Cheng-En Hsu, ... Yung-Cheng Chiu in BMC Musculoskeletal Disorders

   Article Open access 15 July 2024
   

9. Evaluation of the clinical efficacy of using an inverted triangular cannulated compression screw in combination with positive or negative buttress reduction for the healing of femoral neck fractures

   Objective

   We aimed to compare the clinical efficacy of inverted triangular cannulated compression screws combined with Gotfried positive or negative...

   Gang Wang, Cui Tang, ... Gaokai Li in BMC Musculoskeletal Disorders

   Article Open access 15 July 2024
   

10. Tanshinone IIA through the PGK1/PDHK1 Pathway Affecting Macrophage Reprogramming in the Repair Process of Myocardial Infarction

    Ming Li, Li Xu in Cardiovascular Drugs and Therapy

    Article 15 July 2024

11. Global longitudinal active strain energy density (GLASED): age and sex differences between young and veteran athletes

    Background

    Global longitudinal active strain energy density (GLASED) is an innovative method for assessing myocardial function and quantifies the work...

    David H. MacIver, Henggui Zhang, ... David Oxborough in Echo Research & Practice

    Article Open access 15 July 2024
    

12. Impact on Glycemia Risk Index and other metrics in type 1 adult patients switching to Advanced Hybrid Closed-Loop systems: a one-year real-life experience

    Background

    Advanced Hybrid Closed-Loop system (AHCL) has profoundly changed type 1 diabetes therapy. This study primarily aimed to assess the impact...

    Eugenia Resmini, Emanuela Zarra, ... Angela Girelli in European Journal of Medical Research

    Article Open access 15 July 2024
    

13. Correction: Role of hypoxia-mediated pyroptosis in the development of extending knee joint contracture in rats

    Quan-Bing Zhang, Lei Huo, ... Yun Zhou in European Journal of Medical Research

    Article Open access 15 July 2024
    

14. Sex ratio at birth across 100 years in Sweden and risk of cardiovascular disease and all-cause mortality – a national register study

    The human sex ratio at birth (SRB) undergoes temporary changes around a mean proportion of 0.51 male births. SRB has been well studied for...

    Peter M. Nilsson, Kristina Sundquist, ... **njun Li in European Journal of Epidemiology

    Article Open access 15 July 2024
    

15. Epidemiology, outcomes and prognosis of infective endocarditis in Northern Morocco

    Introduction

    Infective endocarditis is a rare but potentially severe disease, associated with significant morbidity and mortality. Our study aims to...

    Badre El Boussaadani, Ilias Soussan, ... Zainab Raissuni in BMC Infectious Diseases

    Article Open access 15 July 2024
    

16. The Ca²⁺-sensing receptor and the pocketome: comparing nature’s complexity with human intervention in receptor modulation

    Edda S. F. Matthees, Carsten Hoffmann in Signal Transduction and Targeted Therapy

    Article Open access 15 July 2024
    

17. Estimated Incidence of Hospitalizations Attributable to RSV Infection Among Adults in Ontario, Canada, Between 2013 and 2019

    Introduction

    Adult respiratory syncytial virus (RSV) burden is underestimated due to non-specific symptoms, limited standard-of-care and delayed...

    Marianna Mitratza, Malak Elsobky, ... Elizabeth Begier in Infectious Diseases and Therapy

    Article Open access 15 July 2024

18. Development of a novel approach for restoration of the meniscus using silk-elastin in a rabbit meniscus injury model

    Background

    Limited healing potential of the meniscus remains a burden for the successful repair of meniscus injuries in the orthopaedic fields....

    Tadashi Inoue, Toshiya Kano, ... Nobuo Adachi in BMC Musculoskeletal Disorders

    Article Open access 15 July 2024
    

19. Changes in the anteroposterior position of the femur relative to the tibia impact patient satisfaction in total knee arthroplasty

    Background

    In this study, we aimed to investigate the preoperative and postoperative anteroposterior position (AP) of the femur relative to the tibia...

    Tomofumi Kinoshita, Kazunori Hino, ... Masaki Takao in BMC Musculoskeletal Disorders

    Article Open access 15 July 2024
    

20. YAP/TAZ interacts with RBM39 to confer resistance against indisulam

    The Hippo pathway and its downstream effectors, Yes-associated protein/transcriptional coactivator with PDZ-binding motif (YAP/TAZ), are essential...

    Toshinori Ando, Kento Okamoto, ... Mikihito Kajiya in Oncogenesis

    Article Open access 15 July 2024