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Prevalence and correlates of common mental disorders among participants of the Uganda Genome Resource: Opportunities for psychiatric genetics research
Genetics research has potential to alleviate the burden of mental disorders in low- and middle-income-countries through identification of new...
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PET imaging of neuroinflammation: any credible alternatives to TSPO yet?
Over the last decades, the role of neuroinflammation in neuropsychiatric conditions has attracted an exponentially growing interest. A key driver for...
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A bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior
The single nucleotide polymorphism rs13166360, causing a substitution of valine (Val) 147 to leucine (Leu) in the adenylyl cyclase 2 (ADCY2), has...
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Assessment of Innovative Pharmacological Targets in Schizophrenia
Purpose of reviewSchizophrenia is a disorder with an approximate prevalence of 1% associated with great impairments in daily life functioning and...
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Problematic Gaming and Gambling: A Systematic Review of Task-Specific EEG Protocols
Even though gaming and gambling bear similar problematic behavioral aspects, there are no recognizable neurophysiological biomarkers or features...
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Microstructural characterization of multiple sclerosis lesion phenotypes using multiparametric longitudinal analysis
Background and objectivesIn multiple sclerosis (MS), slowly expanding lesions were shown to be associated with worse disability and prognosis. Their...
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Patients with complex and very-early-onset ATL1-related spastic paraplegia offer insights on genotype/phenotype correlations and support for autosomal recessive forms of SPG3A
Spastic paraplegia type 3A (SPG3A) is the second most common form of hereditary spastic paraplegia (HSP). This autosomal-dominant-inherited motor...
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Impact of the COVID-19 pandemic on antidepressant consumption in the Central region of Portugal: interrupted time series
PurposeTo evaluate the impact of the pandemic on the consumption of antidepressive agents in Central Portugal.
MethodsTo estimate the causal effect...
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School modality, race and ethnicity, and mental health of U.S. adolescents during the COVID-19 pandemic
BackgroundWhile minoritized ethnoracial groups were most likely to be in online learning during the COVID-19 pandemic, the impact of these...
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Esketamine in depression: putative biomarkers from clinical research
The discovery of racemic ( R , S )-ketamine as a rapid-acting antidepressant and the subsequent FDA approval of its ( S )-enantiomer, esketamine, for...
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Replacement of sedentary behavior with various physical activities and the risk of incident depression: a prospective analysis of accelerator-measured and self-reported UK Biobank data
PurposeTo examine the dose‒response relationships of sedentary behavior (SB) and physical activities (PAs) with depression, and to explore the...
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Surgical strategy in treatment of metopic synostosis in a single centre experience: technical note and quantitative analysis of the outcomes
PurposeTrigonocephaly is the most common craniosynostosis involving orbits. Although some degree of agreement has been reached regarding surgical...
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Application of GWAS summary data and drug-induced gene expression profiles of neural progenitor cells in psychiatric drug prioritization analysis
Common psychiatric disorders constitute one of the most substantial healthcare burdens worldwide. However, drug development in psychiatry remains...
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Association between negative life events and suicidal behavior in adolescents: roles of core self-evaluation, depression and gender
PurposeNegative life events are essential proximal factors that may induce suicidal behavior in adolescents, but the mechanisms connecting this link...
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Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number
Neuroligin-3 ( Nlgn3 ) is an autism-associated cell-adhesion molecule that interacts with neurexins and is robustly expressed in both neurons and...
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Sensory processing patterns among children with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) using short sensory profile and evoked potentials: a case–control study
BackgroundBoth autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are early neurodevelopmental disorders that present...
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Automated classification of brain MRI reports using fine-tuned large language models
PurposeThis study aimed to investigate the efficacy of fine-tuned large language models (LLM) in classifying brain MRI reports into pretreatment,...
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Multimodal training protocols on unstable rather than stable surfaces better improve dynamic balance ability in older adults
BackgroundThere has been growing interest in using unstable devices in training protocols. This study aimed to assess the effectiveness of two...
