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MAGE: Strain Level Profiling of Metagenome Samples
Metagenomic profiling from sequencing data aims to disentangle a microbial sample at lower ranks of taxonomy, such as species and strains. Deep... -
CONSULT-II: Taxonomic Identification Using Locality Sensitive Hashing
Metagenomics is widely used to study the microbiome using environmental samples, and taxonomic classification of reads is a precursor to many... -
OHMI: the ontology of host-microbiome interactions
BackgroundHost-microbiome interactions (HMIs) are critical for the modulation of biological processes and are associated with several...
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Symmetries and the Genetic Code
This essay is devoted to a few results in investigating symmetries in the genetic coding system. The focus is on symmetry relationships in the... -
Levels and building blocks—toward a domain granularity framework for the life sciences
BackgroundWith the emergence of high-throughput technologies, Big Data and eScience, the use of online data repositories and the establishment of new...
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MicrO: an ontology of phenotypic and metabolic characters, assays, and culture media found in prokaryotic taxonomic descriptions
BackgroundMicrO is an ontology of microbiological terms, including prokaryotic qualities and processes, material entities (such as cell components),...
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The Orthology Ontology: development and applications
BackgroundComputational comparative analysis of multiple genomes provides valuable opportunities to biomedical research. In particular, orthology...
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An Evolution Model for Sequence Length Based on Residue Insertion–Deletion Independent of Substitution: An Application to the GC Content in Bacterial Genomes
We introduce here a gene evolution model which is an extension of the time-continuous stochastic IDIS model (Lèbre and Michel in J. Comput. Biol....
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Computational methods in noncoding RNA research
Non protein-coding RNAs (ncRNAs) are a research hotspot in bioinformatics. Recent discoveries have revealed new ncRNA families performing a variety...
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Information capacity of nucleotide sequences and Its applications
The information capacity of nucleotide sequences is defined through the specific entropy of frequency dictionary of a sequence determined with...
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A multiple sequence comparison method
This article presents a new method for the comparison of multiple macromolecular sequences. It is based on a hierarchical sequence synthesis...
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A survey of multiple sequence comparison methods
Multiple sequence comparison refers to the search for similarity in three or more sequences. This article presents a survey of the exhaustive...
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Mathematical tools for molecular genetics data: An annotated bibliography
An annotated bibliography of mathematical and computer analyses of protein and nucleic acid sequences is presented. The major subject areas...