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Ex Vivo Experiments Shed Light on the Innate Immune Response from Influenza Virus
The innate immune response is recognized as a key driver in controlling an influenza virus infection in a host. However, the mechanistic action of...
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Bifurcations in a Dynamical Model of the Innate Immune System Response to Initial Pulmonary Infection
We revisit a dynamical model of the innate immune system response to initial pulmonary infection. By supposing that large pathogen load may not be...
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Mathematical analysis of within-host dengue dynamics with innate and adaptive immune responsess
Dengue is among the most prevalent arboviral disease in humans worldwide. Infection with dengue can cause a wide spectrum of disease indications,...
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Inverse Modelling of the Cellular Immune Response to SARS-CoV-2
The ongoing struggle with COVID-19 persists as most researchers endeavour to find a successful method to curb global pandemics. Consequently, there...
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The Influence of Immune Response on Spreading of Viral Infection
AbstractIn this work we develop a model of viral infection in host tissues in order to study the influence of the immune response on the infection...
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Computational Modeling of Viral Infection and Immune Response in COVID-19 Patients
In December 2019, a novel coronavirus known as SARS-CoV-2 emerged in China and rapidly spread worldwide, resulting in a global pandemic with a...
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Compartmental Model Suggests Importance of Innate Immune Response to COVID-19 Infection in Rhesus Macaques
The pandemic outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly spread worldwide, creating a serious health crisis....
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Age-Related Changes to the Immune System Exacerbate the Inflammatory Response to Pandemic H1N1 Infection
Age-induced dysregulation of the immune response is a major contributor to the morbidity and mortality related to influenza a virus infections....
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Analysis of a mathematical model of immune response to fungal infection
Fungi are cells found as commensal residents, on the skin, and on mucosal surfaces of the human body, including the digestive track and urogenital...
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Modeling the Influenza Virus Dynamics Within a Host
Several mathematical models that describe the dynamics of a virus within a host have been proposed and analyzed. These studies are challenging as the...
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Modelling Immune Memory Development
The cellular adaptive immune response to influenza has been analyzed through several recent mathematical models. In particular, Zarnitsyna et al....
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The Role of Antigen-Competitive Dynamics in Regulating the Immune Response
The clonal expansion of T cells during an infection is tightly regulated to ensure an appropriate immune response against invading pathogens....
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The Interferon Influence on the Infection Wave Propagation
Viral infection spreads in the infected tissue or in cell culture as a reaction-diffusion wave due to virus replication in the infected cells and its...
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Mathematical Model of Triple-Negative Breast Cancer in Response to Combination Chemotherapies
Triple-negative breast cancer (TNBC) is a heterogenous disease that is defined by its lack of targetable receptors, thus limiting treatment options...
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Modeling the Effect of Memory in the Adaptive Immune Response
It is well understood that there are key differences between a primary immune response and subsequent responses. Specifically, memory T cells that...
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In-Host Dynamics of the Human Papillomavirus (HPV) in the Presence of Immune Response
High-risk human papillomaviruses (HPV) are one of the major causative agents of cervical cancer in women globally, and it is estimated that about 80%...
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Modeling dynamics of cancer virotherapy with immune response
Virotherapy is a therapeutic treatment for cancer. It uses genetically engineered viruses to selectively infect, replicate in, and destroy cancer...
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NIAID/SMB Workshop on Multiscale Modeling of Infectious and Immune-Mediated Diseases
On July 19th, 2023, the National Institute of Allergy and Infectious Diseases co-organized a workshop with the Society of Mathematical Biology, with...
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A Multi-Scale Immune System Simulator for the Onset of Type 2 Diabetes
Type 2 diabetes mellitus (T2D), the most common form of diabetes, is a chronic metabolic disorder characterized by hyperglycemia, insulin resistance,...
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COVID-19-associated pulmonary aspergillosis in immunocompetent patients: a virtual patient cohort study
The opportunistic fungus Aspergillus fumigatus infects the lungs of immunocompromised hosts, including patients undergoing chemotherapy or organ...
