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Advances in Network-Based Drug Repositioning
Network-based drug repositioning is a fast-growing approach to computational drug repositioning that has had a powerful impulse at the onset of the...
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Verifying Hypotheses of Drug Bioequivalence
AbstractThe problem of testing pharmaceuticals on their bioequivalence is considered. Investigations of drug bioequivalence are the basis for...
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Optimal dosing strategy and sensitivity analysis of a within-host drug resistance model with continuous and impulsive drug treatment
In this work, we investigate the dynamics of the drug-resistance models with the continuous and impulsive drug treatment. Firstly, a mathematical...
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Multiple sampling schemes and deep learning improve active learning performance in drug-drug interaction information retrieval analysis from the literature
BackgroundDrug-drug interaction (DDI) information retrieval (IR) is an important natural language process (NLP) task from the PubMed literature. For...
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Statistical Analysis of Two-Compartment Pharmacokinetic Models with Drug Non-adherence
Poor drug adherence is considered one of major barriers to achieving the clinical and public health benefits of many pharmacotherapies. In the...
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Mathematical modeling and bifurcation analysis for a biological mechanism of cancer drug resistance
Drug resistance is one of the most intractable issues in targeted therapy for cancer diseases. It has also been demonstrated to be related to cancer...
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Enriching the
FIDEO ontology with food-drug interactions from online knowledge sourcesThe increasing number of articles on adverse interactions that may occur when specific foods are consumed with certain drugs makes it difficult to...
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Modeling Mutation-Driven Emergence of Drug-Resistance: A Case Study of SARS-CoV-2
Drug-Resistance (DR) remains a global public health concern for managing several infectious diseases, but little work has been done to explore its...
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Co-dynamic Model of Drug Trafficking and Money Laundering Coupled with Fractional Derivative
Drug trafficking and money laundering are nation destroyers which need rapid solution to the mayhem because the menace has ruined livelihoods and...
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A Spatial Analysis of Drug Dealing in Mexico City
This paper presents an application of global and local Moran’s IMoran’s index measures of spatial association in the detection of drug dealingDrug...
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Numerical Simulation and Validation of a Nonlinear Differential System for Drug Release Boosted by Light
In this work, motivated by the mathematical modeling of light-enhanced drug delivery, we look at the numerical solution of a nonlinear system of...
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Electromechanical In Silico Testing Alters Predicted Drug-Induced Risk to Develop Torsade de Pointes
Torsade de Pointes (TdP) is a type of ventricular tachycardia that can occur as a side effect of several medications. The Comprehensive in vitro...
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A Multi-Drug Pharmacokinectic Optimal Control Approach in Cancer Chemotherapy
The mathematical study of the growth and treatment of cancer has been of great interest to researchers in the recent past as that can help clinical...
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Designing Drug Regimens that Mitigate Nonadherence
Medication adherence is a well-known problem for pharmaceutical treatment of chronic diseases. Understanding how nonadherence affects treatment...
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Design Framework and Tools for Solid Drug Product Manufacturing Processes
This chapter presents a design framework and associated new assessment tools for solid drug product manufacturing processes. The framework describes...
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An Application of the Grünwald-Letinkov Fractional Derivative to a Study of Drug Diffusion in Pharmacokinetic Compartmental Models
In this study, we present the application of fractional calculus (FC) in biomedicine. We present three different integer order pharmacokinetics...
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The Impact of Mechano-Electric Feedback on Drug- and Stretch- Induced Arrhythmia Using a Computational Model of Cardiac Electromechanics
Mechano-electric feedback (MEF) is thought to be an important factor in the increased arrhythmic risk observed clinically in heart failure and...
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Investigation of a Drug Release Moving Boundary Problem in a Swelling Polymeric Device
This paper considers a drug delivery polymeric device in contact with a solvent as a nonlinear moving boundary problem. In this problem, the drug...
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QSAR—An Important In-Silico Tool in Drug Design and Discovery
QSAR (Quantitative structure–activity relationship) study is important thirst area in drug design and discovery via computational studies of...
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Optimal Interruption of P. vivax Malaria Transmission Using Mass Drug Administration
Plasmodium vivax is the most geographically widespread malaria-causing parasite resulting in significant associated global morbidity and mortality....
