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Protein receptors and ion channels
One essential requirement of sensory eukaryotic cells and single-cell organisms such as bacteria is to monitor the environment and to respond...
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A robust optimal control framework for controlling aberrant RTK signaling pathways in esophageal cancer
This study presents a new framework for obtaining personalized optimal treatment strategies targeting aberrant signaling pathways in esophageal...
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Modeling the Development of Cellular Exhaustion and Tumor-Immune Stalemate
Cellular exhaustion in various immune cells develops in response to prolonged stimulation and overactivation during chronic infections and in cancer....
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A Mathematical Model of Cell Clustering
This paper presents a numerical method for modelling cell migration. The aim of this research is to generate a model that accurately simulates to...
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Simulating Temporal and Spatial Changes in Biological Phenomena
In the previous chapter, we discussed the mathematical model of ordinary differential equations, which considers only the time derivative without...
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The Issues Regarding the Organization of the Human Retina: A Cybernetic Approach
The issues in the organization of the human retina are analyzed from the point of view of cybernetics. In particular, hypotheses are formed regarding...
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Realizing Synaptic Signal Transmission During Astrocyte-Neuron Interactions within the EMI Framework
The tripartite synapse or “neural threesome” refers to the interplay in the synapse between neighbouring neurons, the synaptic cleft, and the...
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Adaptive Filtering of Distributed Data Based on Modeling the Perception Mechanisms of Living Sensory Systems
The article is devoted to the results of the adaptive filtering synthesis in the frames of neuromorphic model inspired by biological sensory system....
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Modelling Plasmid-Mediated Horizontal Gene Transfer in Biofilms
In this study, we present a mathematical model for plasmid spread in a growing biofilm, formulated as a nonlocal system of partial differential...
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Inverse Modelling of the Cellular Immune Response to SARS-CoV-2
The ongoing struggle with COVID-19 persists as most researchers endeavour to find a successful method to curb global pandemics. Consequently, there...
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Mathematical Modeling of the Dimerization of EGFR and ErbB3 in Lung Adenocarcinoma
The most common driver mutations in lung adenocarcinoma occur in the EGFR gene. Gefitinib, an EGFR tyrosine kinase inhibitor, is an effective therapy...
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Travelling Wave Solutions and Stationary Solutions of a Reaction-Diffusion-ODE System
The aim of this paper is to study a reaction-diffusion-ODE system which describes coupling of fast reacting receptors with ligands via diffusion in a...
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Mathematical Characterization of Private and Public Immune Receptor Sequences
Diverse T and B cell repertoires play an important role in mounting effective immune responses against a wide range of pathogens and malignant cells....
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Biological Neural Networks
A biological neural network is composed of a group of connected neurons. A single neuron may be connected to many other neurons and the total number...
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The Search for Cancer Drivers
During the past decade, significant technological and computational advances have provided unprecedented opportunities for gaining a better...
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A Multi-Scale Immune System Simulator for the Onset of Type 2 Diabetes
Type 2 diabetes mellitus (T2D), the most common form of diabetes, is a chronic metabolic disorder characterized by hyperglycemia, insulin resistance,...
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Tumor Prediction Using Microarray Gene Expression Profiles Through SVM and CBFS
The introduction to microarray technology has created a breakthrough in gene profiling which in turn has led to precise prediction of tumors....
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Axons, dendrites, and synapses
Chapter 2 and chapter 3 considered single neuron models that idealised the nerve cell as a point or patch of cell membrane in which voltage is the...
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Modelling Cellular Interactions and Dynamics During Kidney Morphogenesis
Kidney disease and renal disorders account for a significant proportion of health complications in mid-late adulthood worldwide. Many renal...
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Percolation in Biological Systems
Most biological systems are so complex that they preclude any reasonable description in terms of the exact interactions among their fundamental...