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Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells
Therapeutic genome editing of haematopoietic stem cells (HSCs) would provide long-lasting treatments for multiple diseases. However, the in vivo...
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Enhanced homing of mesenchymal stem cells for in situ niche remodeling and bone regeneration
Mesenchymal stem cells (MSCs) transplantation is a promising strategy for osteoporosis treatment. However, limited sources and poor tissue-homing...
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Shilajit Boosts Osteogenic Ability of Mesenchymal Stem Cells for Regeneration of Rat Bone Defect
PurposeMesenchymal stem cell (MSC) therapy and using herbal extracts such as Shilajit have shown promising results in bone fracture repair. The...
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3D printed OCP bone scaffold with alginate enhancing osteogenic differentiation in MG-63 cells
3D printing technology using calcium phosphate materials such as octacalcium phosphate (OCP, Ca 8 H 2 [PO 4 ] 6 ·5H 2 O) has emerged as a precise approach for...
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A novel, microfluidic high-throughput single-cell encapsulation of human bone marrow mesenchymal stromal cells
The efficacy of stem-cell therapy depends on the ability of the transplanted cells to escape early immunological reactions and to be retained at the...
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Biology of Ceramic Bone Substitutes
The human skeleton has the miraculous capacity of healing itself when needed through a cascade known as bone remodeling. However, bone tissue is not... -
Behavioural responses of bone-like cells on dense and porous dicalcium phosphate dihydrate-coated β-tricalcium phosphate granules
The present study investigated the behavioural response of bone-like cells towards dense and porous dicalcium phosphate dihydrate (DCPD)-coated...
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Cartilage-like protein-polysaccharide hybrid hydrogel for enhancing chondrogenic differentiation of bone marrow mesenchymal stem cells
The regeneration of articular cartilage posed a formidable challenge due to the restricted treatment efficacy of existing therapies. Scaffold-based...
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A bone adhesive enhances osteoporotic fracture repair by regulating bone homeostasis
Patients suffering from osteoporotic fractures often require effective fixation and subsequent bone repair. However, the currently available...
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Three-dimensional printed polylactic acid and hydroxyapatite composite scaffold with urine-derived stem cells as a treatment for bone defects
Bone defects still pose various challenges in osteology. As one treatment method for bone defects, tissue engineering requires biomaterials with good...
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Apoptotic vesicles rejuvenate mesenchymal stem cells via Rab7-mediated autolysosome formation and alleviate bone loss in aging mice
Aging skeletons display decreased bone mass, increased marrow adiposity, and impaired bone marrow mesenchymal stem cells (MSCs). Apoptosis is a...
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Guided bone regeneration in long-bone defect with a bilayer mineralized collagen membrane
Bone regeneration for large, critical-sized bone defects remains a clinical challenge nowadays. Guided bone regeneration (GBR) is a promising...
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Polymeric Biodegradable Biomaterials for Tissue Bioengineering and Bone Rejuvenation
The necessity for multiple surgeries is decreased by tissue engineering techniques, which also lessen donor site morbidity in graft procedures.... -
Effect of Bone Marrow Mesenchymal Stem Cells on a Short-Term Induced Diabetic Retinopathy in Adult Female Albino Rats
BackgroundWorldwide, diabetic retinopathy (DR) remains the leading cause of visual impairment that often leads to irreversible vision loss. Despite...
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Bone Marrow Mesenchymal Stem Cells Expanded Inside the Nichoid Micro-Scaffold: a Focus on Anti-Inflammatory Response
PurposeMesenchymal stem cells (MSCs) represent a promising source for stem cell therapies in numerous diseases, including pediatric respiratory...
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Psoralen synergies with zinc implants to promote bone repair by regulating ZIP4 in rats with bone defect
BackgroundThe regulation of dose-dependent biological effects induced by biodegradation is a challenge for the production of biodegradable...
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Polymeric Nano-Composite Scaffolds for Bone Tissue Engineering: Review
Bone tissues have an amazing ability to repair and regenerate. However, complex bone fractures and defects still present a significant challenge to... -
Biodegradable Nanocomposite as Advanced Bone Tissue Scaffold
The continuous advancements in nanotechnology, understanding of reinforcement procedures of nanoscale materials, and related fabrication technologies... -
The potential of the mineralized bone allograft block as an appropriate candidate for bone tissue engineering in periodontology
In this research, an allograft mineralized bone block was processed through decellularizing and lyophilizing after approving the sterility...
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Comparison of osteogenesis of bovine bone xenografts between true bone ceramics and decalcified bone matrix
Xenograft bone scaffolds have certain advantages such as mechanical strength, osteoinductive properties, sufficient source and safety. This study...