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Mutually reinforcing nanofactory mimicking controllable “cluster bomb” for synergistic diagnosis and treatment of hypoxic cancer
Multimodal therapy presents one of the most promising strategies for combining multiple therapies to treat the usually complex and insidious tumor...
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Engineering of smart nanostructured lipid carriers encapsulated in gold nanocomposites and camptothecin for synergistic photothermal and chemotherapy treatment of ovarian cancer
Ovarian cancer describes a group of disorders that start in the ovaries or adjacent fallopian tubes and peritoneum. It is becoming increasingly clear...
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Dual-functional extracellular vesicles enable synergistic treatment via m6A reader YTHDF1-targeting epigenetic regulation and chemotherapy
Chemotherapy remains one of the most prevailing strategies for cancer treatment. However, its treatment effect is hampered by drug resistance,...
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Covalent organic framework-based nanozyme for cascade-amplified synergistic cancer therapy
Due to the limited concentration of hydrogen peroxide (H 2 O 2 ) in the tumor microenvironment, peroxidase (POD)-mimicking nanozyme-mediated catalytic...
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pH responsive dextran nanoparticles loaded with doxorubicin and RITA against cancer cells: synergistic inhibitory effects
Cancer is the second leading cause of death globally. Despite of significant advances in combination therapy of chemotherapeutic drugs, its...
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A pH-Sensitive nanodrug based on ortho ester-coupled ibuprofen and doxorubicin for synergistic treatment of tumors
Nano-drug delivery system (nDDS) that could be used for combination cancer therapy were expected to improve the chemotherapy effect of doxorubicin...
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Bionic immunoactivator copresenting autophagy promoting and costimulatory molecules for synergistic cancer immunotherapy
Immunotherapy has great promise in improving malignant tumor treatment. However, the efficacy of existing strategies is often limited by the...
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Hollow carbon nanospheres loaded with upconversion nanoparticles for chemo-photothermal synergistic cancer therapy
Nanomaterials possess multidisciplinary capabilities in cancer diagnosis and treatment, including imaging and therapeutic, and thus have wide range...
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Gold-capsuled polymeric nanomedicine for synergistic breast cancer photo-chemotherapy
Photo-chemotherapy is a potent anticancer therapeutic approach. Herein, we designed a gold-capsulated lapatinib nanomedicine for breast cancer...
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Smart nanoplatform with programmed release of dihydroartemisinin and Fe2+ self-supply for synergistic cancer therapy
Dihydroartemisinin (DHA) has caught worldwide attention as an innovative antitumor drug. However, the inherent defects of DHA reduce its transport...
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Charge-reversible crosslinked nanoparticle for pro-apoptotic peptide delivery and synergistic photodynamic cancer therapy
Although anti-cancer nanotherapeutics have made breakthroughs, many remain clinically unsatisfactory due to limited delivery efficiency and...
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Synergistic anticancer effect of Pistacia lentiscus essential oils and 5-Fluorouracil co-loaded onto biodegradable nanofibers against melanoma and breast cancer
Chemoresistance and severe toxicities represent major drawbacks of chemotherapy. Natural extracts, including the essential oils of Pistacia lentiscus ...
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Synergistic co-administration of docetaxel and curcumin to chemoresistant cancer cells using PEGylated and RIPL peptide-conjugated nanostructured lipid carriers
BackgroundA targeted co-administration system of docetaxel (DTX) and curcumin (CUR) using a PEG-modified RIPL peptide (IPLVVPLRRRRRRRRC)-conjugated...
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Enhanced cancer immunotherapy through synergistic ferroptosis and immune checkpoint blockade using cell membrane-coated nanoparticles
BackgroundImmune checkpoint blockade (ICB) has achieved unprecedented success in inhibiting the progression and metastasis of many cancers. However,...
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Assembling defined DNA nanostructures with anticancer drugs: a metformin/DNA complex nanoplatform with a synergistic antitumor effect for KRAS-mutated lung cancer therapy
Herein, a strategy is proposed to simultaneously deliver the small-molecule drug metformin and siRNA with self-assembled DNA nanostructures. The...
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A biodegradable nanodrug with highly efficient treatment effect by remodeling tumor microenvironment and manipulating energy metabolism against colorectal cancer
Cisplatin (CDDP), a widely used chemotherapy drug for colorectal cancer, suffers from rapid clearance, resistance, and nonspecific delivery....
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Biomimetic mesoporous polydopamine nanoparticles for MRI-guided photothermal-enhanced synergistic cascade chemodynamic cancer therapy
Traditional anticancer treatments fail to significantly improve prognoses, and exploration of novel promising therapeutic modalities is urgently...
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Organic–Inorganic Nanohybrids in Cancer Treatment
Nanohybrids more specifically organic–inorganic nanohybrids are providing a vast range of functionalities for diagnostics, drug delivery, and...
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Bionic natural small molecule co-assemblies towards targeted and synergistic Chemo/PDT/CDT
BackgroundMulti-component nano-delivery systems based on chemotherapy (chemo)- photodynamic therapy (PDT)- chemodynamic therapy (CDT) have gained...
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Carbon-coated magnetite nanoclusters with NIR-II absorbance for imaging-guided photothermal-chemodynamic synergistic therapy
Chemodynamic therapy (CDT) is an emerging therapeutic modality to treat cancer based on magnetite nanozymes. However, the low catalytic capacity and...
