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Bufalin-loaded vitamin E succinate-grafted chitosan oligosaccharide/RGD-conjugated TPGS mixed micelles inhibit intraperitoneal metastasis of ovarian cancer
BackgroundIntraperitoneal metastasis is one of the major causes of the high mortality rate of ovarian cancer. Bufalin (BU) is an effective component...
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Safety evaluation of biopolymer immune implants in rats and rabbits as well as therapeutic effects on gastric cancer peritoneal metastasis carcinoma
Peritoneal metastasis carcinoma (PMC), as an extremely aggressive malignant tumor with high metastatic potential, typically exhibits an average...
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Recent Status of the Current Clinical Trials Going on for Superparamagnetic Materials
Superparamagnetic iron-oxide nanoparticles (SPIONS) due to their intrinsic property of superparamagnetism are widely explored and studied as a...
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Nanomaterials for visualized tumor surgical navigation and postoperative recurrence inhibition
Preoperative localization of the tumor sites and intraoperative real-time monitoring are essential for precise surgery but are meanwhile challenging...
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Engineering of ultrasound contracts agents-focused cabazitaxel-loaded microbubbles nanomaterials induces cell proliferation and enhancing apoptosis in cancer cells
Tumour-induced sentinel lymph node diagnosis and metastatic therapeutic techniques are limited by current strategies nowadays. Herein, we combined...
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Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment
AbstractThe perplexing issues related to positive surgical margins and the considerable negative consequences associated with systemic chemotherapy...
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Immunological conversion of solid tumours using a bispecific nanobioconjugate for cancer immunotherapy
Solid tumours display a limited response to immunotherapies. By contrast, haematological malignancies exhibit significantly higher response rates to...
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A preclinical platform for assessing long-term drug efficacy exploiting mechanically tunable scaffolds colonized by a three-dimensional tumor microenvironment
BackgroundLong-term drug evaluation heavily relies upon rodent models. Drug discovery methods to reduce animal models in oncology may include...
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Evaluation of the anticancer potential of CD44 targeted vincristine nanoformulation in prostate cancer xenograft model: a multi-dynamic approach for advanced pharmacokinetic evaluation
The in vivo anticancer potential of vincristine (VC) loaded, thiolated chitosan-based nanoformulation (NFs) with an outer hyaluronic acid (VC-loaded...
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Carboxymethyl Chitosan for Drug and Vaccine Delivery: An Overview
Chitosan is a biopolymer derived from natural chitin, which is the principal component of the exoskeletons of crustaceans and insects as well as of...
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Reprogramming the tumor microenvironment with biotechnology
The tumor microenvironment (TME) is a unique environment that is developed by the tumor and controlled by tumor-induced interactions with host cells...
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Potential Challenges in Anti-angiogenic Nanotherapies and Conclusion
Since last few decades, several nanoparticles-based medicines were tested and clinically used for various biomedical applications including cancer...
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Identification of LRG1 targeting peptide and its application in targeted imaging for breast cancer
Breast cancer remains a leading cause of morbidity and mortality among women worldwide, emphasizing the urgent need for enhanced diagnostic and...
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Albumin-binding photosensitizer capable of targeting glioma via the SPARC pathway
BackgroundMalignant glioma is among the most lethal and frequently occurring brain tumors, and the average survival period is 15 months. Existing...
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Impact of Stimuli-Responsive Biomaterials in Gynecological Cancer Therapy
Gynecological cancers, predominantly cervical, ovarian, uterine, and vaginal, are among the most challenging cancers to treat due to their complex...
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Targeted Therapy for Neurological Disorders Using Nanomaterial-Based Drug Delivery Vehicle
Globally, neurological disorders possess great impact on human health and social system. The available current medical therapies have increased the...
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Nanoparticles targeting tumor-associated macrophages: A novel anti-tumor therapy
The immunosuppressive tumor microenvironment (TME) is crucial in the occurrence of tumorigenesis, metastasis, and drug resistance. Among all stromal...
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Immunogenic camptothesome nanovesicles comprising sphingomyelin-derived camptothecin bilayers for safe and synergistic cancer immunochemotherapy
Despite the enormous therapeutic potential of immune checkpoint blockade (ICB), it benefits only a small subset of patients. Some chemotherapeutics...
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Entry and exit of extracellular vesicles to and from the blood circulation
Extracellular vesicles (EVs) are biological nanoparticles that promote intercellular communication by delivering bioactive cargo over short and long...
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A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells
Tumour heterogeneity remains a major challenge in cancer therapy owing to the different susceptibility of cells to chemotherapy within a solid...
