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Responsive biomaterials: optimizing control of cancer immunotherapy
Immunotherapy has emerged as an eminent and effective modality in the treatment of cancer. However, current cancer immunotherapies lack spatial and...
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Application of nanoscale metal–organic frameworks in tumor immunotherapy
Immunotherapy has attracted wide attention because it can not only kill tumor cells but also effectively prevent tumor recurrence. However, due to...
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Emerging biomaterials for tumor immunotherapy
BackgroundThe immune system interacts with cancer cells in various intricate ways that can protect the individual from overproliferation of cancer...
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Lipid nanoparticle-based mRNA delivery systems for cancer immunotherapy
Cancer immunotherapy, which harnesses the power of the immune system, has shown immense promise in the fight against malignancies. Messenger RNA...
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Dynamic shielding of bacterial outer membrane vesicles for safe and efficient chemo-immunotherapy against tumors
Bacterial outer membrane vesicles (OMVs) are potent immunostimulants of regulating the tumor microenvironment (TME) for immunotherapy, and can be...
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Research progress on tumor whole-cell vaccines prepared with nanoparticles for tumor immunotherapy
Tumor vaccines are a promising approach to activate patient’s own immune system to fight against tumor. Traditional tumor vaccines utilize tumor...
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Piperazine-derived ionizable lipids for enhanced mRNA delivery and cancer immunotherapy
Messenger ribonucleic acid (mRNA)-based therapeutics hold great prospects in disease treatment and lipid nanoparticles (LNPs) are the most...
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Bionic immunoactivator copresenting autophagy promoting and costimulatory molecules for synergistic cancer immunotherapy
Immunotherapy has great promise in improving malignant tumor treatment. However, the efficacy of existing strategies is often limited by the...
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NK cells encapsulated in micro/macropore-forming hydrogels via 3D bioprinting for tumor immunotherapy
BackgroundPatients face a serious threat if a solid tumor leaves behind partial residuals or cannot be completely removed after surgical resection....
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Responsive manganese-based nanoplatform amplifying cGAS-STING activation for immunotherapy
BackgroundThe activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signaling...
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Reprogramming tumor-immune cell communication with a radiosensitive nanoregulator for immunotherapy
Modulating tumor-associated macrophages from tumor-promoting M2 to tumoricidal M1 phenotype is promising for anti-tumor immunotherapy but remains...
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Multifunctional RGD coated a single-atom iron nanozyme: A highly selective approach to inducing ferroptosis and enhancing immunotherapy for pancreatic cancer
Nanozyme is a new promising approach to cancer therapy for its ability to induce ferroptosis by activating H 2 O 2 via a traditional radical pathway and...
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Novel bispecific aptamer targeting PD-1 and nucleolin for cancer immunotherapy
BackgroundImmune checkpoint blockade (ICB) is a promising strategy for cancer treatment and has achieved remarkable clinical results. Further...
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Black TiO2-based nanoparticles as Toll-like receptor stimulator delivery system for enhanced photothermal-immunotherapy of pancreatic cancer
BackgroundThe tumor-specific immune responses, essential for removing residual lesions and preventing tumor metastases, can be stimulated by...
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Oxyhaemoglobin saturation NIR-IIb imaging for assessing cancer metabolism and predicting the response to immunotherapy
In vivo quantitative assessment of oxyhaemoglobin saturation (sO 2 ) status in tumour-associated vessels could provide insights into cancer metabolism...
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Engineering TGF-β inhibitor-encapsulated macrophage-inspired multi-functional nanoparticles for combination cancer immunotherapy
BackgroundThe emergence of cancer immunotherapies, notably immune checkpoint inhibitors, has revolutionized anti-cancer treatments. These treatments,...
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Targeting nano-regulator based on metal–organic frameworks for enhanced immunotherapy of bone metastatic prostate cancer
Bone metastasis is the main cause of death in patients with prostate cancer (PCa), but there lacks effective treatment method. Immunotherapy shows...
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Immunogenic cell death effects induced by doxorubicin improved chemo-immunotherapy via restoration of granzyme B activity
Chemotherapy remains one of the irreplaceable treatments for cancer therapy. The use of immunogenic cell death (ICD)-inducing chemotherapeutic drugs...
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Light-activated arginine-rich peptide-modified nanoparticles for deep-penetrating chemo-photo-immunotherapy of solid tumor
Poor permeation of drugs and “immune-cold” tumor microenvironment in solid tumors are the two major challenges which lead to the inefficient...
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A composite peptide-supramolecular microneedle system for melanoma immunotherapy
Despite recent advances in melanoma treatment through the use of antibody immunotherapy, the clinical benefit remains restricted by its inefficient...
