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Milestones in tumor vascularization and its therapeutic targeting
Research into the mechanisms and manifestations of solid tumor vascularization was launched more than 50 years ago with the proposition and...
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HIF-1α promotes kidney organoid vascularization and applications in disease modeling
BackgroundKidney organoids derived from human pluripotent stem cells (HiPSCs) hold huge applications for drug screening, disease modeling, and cell...
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Advances in Biomaterials for Promoting Vascularization
Purpose of ReviewTissue engineered constructs (TECs)—commonly developed using natural or synthetic biomaterials—are crucially needed for addressing...
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Cerebral arterial vascularization of the scimitar-horned oryx (Oryx dammah)
The Scimitar-horned Oryx ( Oryx dammah) is a large terrestrial mammal native to Africa. Since the year 2000, it is classified as extinct in the wild....
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Methods for vascularization and perfusion of tissue organoids
Tissue organoids or “mini organs” can be invaluable tools for understanding health and disease biology, modeling tissue dynamics, or screening...
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Gene expression of iron transporters, markers of vascularization and structural integrity in placenta of mothers with and without anemia
ObjectiveTo compare the mRNA expression of placental iron transporters (TfR-1 and FPN), markers of placental vascularization (VEGF and sFLT1) and...
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Isolation of ready-made rat microvessels and its applications in effective in vivo vascularization and in angiogenic studies in vitro
Despite recent advances in the differentiation of human pluripotent stem cells into multiple cell types for application in replacement therapies,...
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Dynamic differentiation of F4/80+ tumor-associated macrophage and its role in tumor vascularization in a syngeneic mouse model of colorectal liver metastasis
Tumor-associated macrophages (TAMs) are highly heterogeneous and play vital roles in tumor progression. Here we adopted a C57BL/6 mouse model...
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Pelargonidin inhibits vascularization and metastasis of brain gliomas by blocking the PI3K/AKT/mTOR pathway
Pelargonidin has attracted much attention in many cancers. Whether the growth of glioma inhibited by pelargonidin is related to the PI3K/AKT/mTOR...
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Vascularization of Microvascular Fragment Isolates from Visceral and Subcutaneous Adipose Tissue of Mice
Background:Adipose tissue-derived microvascular fragments (MVF) represent effective vascularization units for tissue engineering. Most experimental...
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Toxicological Analysis by Assessment of Vascularization and Cell Viability Using the Chicken’s Chorioallantoic Membrane (CAM Assay)
The chorioallantoic membrane (CAM) assay is an increasingly popular method using a hen’s egg as an experimental organism. Animal models have been...
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Use of Human Gingival Fibroblasts for Pre-Vascularization Strategies in Oral Tissue Engineering
Background:Cocultures of human gingival fibrobasts (hGF) and endothelial cells could enhance regeneration and repair models as well as improve...
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Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction
Myocardial infarction (MI) is a leading cause of death worldwide, largely because efficient interventions to restore cardiac function after MI are...
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Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies
Cellular senescence is a state of permanent growth arrest that plays an important role in wound healing, tissue fibrosis, and tumor suppression....
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The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy
Millions of people have been affected ever since the emergence of the corona virus disease of 2019 (COVID-19) outbreak, leading to an urgent need for...
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The vascularization, innervation and myogenesis of early regenerated tail in Gekko japonicus
Many species of lizards are capable of tail regeneration. There has been increased interest in the study of lizard tail regeneration in recent years...
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Surface Creasing-Induced Micropatterned GelMA Using Heating-Hydration Fabrication for Effective Vascularization
BackgroundSurface modification is used to modify the biomaterials for the regulation of cell culture using different approaches, such as chemical...
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Exosomes derived from stem cells from apical papilla promote craniofacial soft tissue regeneration by enhancing Cdc42-mediated vascularization
BackgroundReconstruction of complex critical-size defects (CSD) in the craniofacial region is a major challenge, and soft tissue regeneration is...
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Apical Dominance and Vascularization
The hormonal signals that induce vascular differentiation are the controlling signals that synchronize plant development, organ growth regulation,...
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Multipotent adult progenitor cells grown under xenobiotic-free conditions support vascularization during wound healing
BackgroundCell therapy has been evaluated pre-clinically and clinically as a means to improve wound vascularization and healing. While translation of...
