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PATJ inhibits histone deacetylase 7 to control tight junction formation and cell polarity
The conserved multiple PDZ-domain containing protein PATJ stabilizes the Crumbs-Pals1 complex to regulate apical-basal polarity and tight junction...
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Proinflammatory cytokines suppress stemness-related properties and expression of tight junction in canine intestinal organoids
Recent advancements in canine intestinal organoid research have paved the way for the development of enhanced in vitro models, crucial for exploring...
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Aflatoxin M1 decreases the expression of genes encoding tight junction proteins and influences the intestinal epithelial integrity
Aflatoxin M1 (AFM1) is a mycotoxin that is commonly found as a milk contaminant, and its presence in milk has been linked to cytotoxicity. The...
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Tight Junctions in Inflammation and Cancer
This book provides an updated account of tight junctions of different epithelia and endothelia and addresses their anatomy, biochemistry, physiology,...
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The Role of Tight Junction Proteins in Cancer
Tight junctions (TJs) proteins are the network of proteins that play a major role in cell–cell communication and maintaining cell polarity. TJs...
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The role of mir-197-3p in regulating the tight junction permeability of celiac disease patients under gluten free diet
BackgroundCeliac disease (CD) is a hereditary immune-mediated disorder, which is along with the enormous production of pro-inflammatory cytokines and...
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Endocytosis of Tight Junction Proteins: A Pathway for Barrier Remodeling
The tight junction complex is a central component of barrier tissues by occluding the paracellular space. Environmental and intrinsic signals...
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Tight Junctions
This volume explores the dynamic topic of tight junctions. The book focuses on tight junctions' role in sealing adjacent epithelial cells in a narrow...
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Low-molecular-weight heparin ameliorates intestinal barrier dysfunction in aged male rats via protection of tight junction proteins
The intestinal barrier weakens and chronic gut inflammation occurs in old age, causing age-related illnesses. Recent research shows that...
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Decreased ZO1 expression causes loss of time-dependent tight junction function in the liver of ob/ob mice
Diabetes patients are at a high risk of develo** complications related to angiopathy and disruption of the signal transduction system. The liver is...
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NMMHC IIA triggered lipid metabolize reprogramming resulting in vascular endothelial cellular tight junction injury
Background and purposeNonmuscle myosin heavy chain IIA, played an essential role in the promotion of tight junction injury in vascular endothelial...
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Methyl-beta-Cyclodextrin Alters the Level of Tight Junction Proteins in the Rat Cerebrovascular Endothelium
AbstractThe blood–brain barrier (BBB) provides optimal conditions for the functioning of brain neurons. The barrier properties of the cerebrovascular...
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Regulation of Tight Junction by Cadherin Adhesion and Its Implication in Inflammation and Cancer
Epithelial cells interact with their cellular microenvironment through the formation of different interactions between the plasma membrane-localized...
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The Effects of Zinc Oxide Nanoparticles on Antioxidation, Inflammation, Tight Junction Integrity, and Apoptosis in Heat-Stressed Bovine Intestinal Epithelial Cells In Vitro
Zinc oxide nanoparticles (nano-ZnO) have diverse applications in numerous biomedical processes. The present study explored the effects of these...
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MiRNA-132/212 regulates tight junction stabilization in blood–brain barrier after stroke
MicroRNA-132/212 has been supposed as a critical gene related to the blood–brain barrier (BBB) protection after stroke, but its regulation pathway...
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Molecular Architecture and Function of Tight Junctions
Tight junctions, also called zonula occludens, are supramolecular cell–cell adhesion complexes crucial for the architecture of epithelial tissues and...
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Inflammation and Cancer: Role of Tight Junctions
Tight junctions are critical for the homeostatic maintenance of epithelial barrier integrity, especially in the gastrointestinal tract. In addition,...
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Tight Junction Proteins as Emerging Drug Targets: Expanding the Horizons from Inflammation to Cancer
Tight junctions (TJ), located at the most topical part of the cells, are multi-protein complexes that form a formidable barrier governing the...
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Endothelial-specific insulin receptor substrate-1 overexpression worsens neonatal hypoxic-ischemic brain injury via mTOR-mediated tight junction disassembly
Hypoxic-ischemic (HI) encephalopathy is the major cause of mortality and disability in newborns. The neurovascular unit is a major target of acute...
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Selenium Counteracts Tight Junction Disruption and Attenuates the NF-κB-Mediated Inflammatory Response in Staphylococcus aureus-Infected Mouse Mammary Glands
Tight junctions (TJs) are the key determinant of barrier function in the mammary gland, with their disruption being associated with the pathogenesis...
