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Signatures of positive selection in the mitochondrial genome of neotropical freshwater stingrays provide clues about the transition from saltwater to freshwater environment
Neotropical freshwater stingrays (subfamily Potamotrygoninae) are carnivorous bottom feeder batoids widely distributed in most river basins of South...
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Loo** out of control: R-loops in transcription-replication conflict
Transcription-replication conflict is a major cause of replication stress that arises when replication forks collide with the transcription...
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Insight into the evolutionary and domesticated history of the most widely cultivated mushroom Agaricus bisporus via mitogenome sequences of 361 global strains
Agaricus bisporus is the most widely cultivated edible mushroom in the world with a only around three hundred years known history of cultivation....
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Intertwining roles of R-loops and G-quadruplexes in DNA repair, transcription and genome organization
R-loops are three-stranded nucleic acid structures that are abundant and widespread across the genome and that have important physiological roles in...
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Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids
RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and are crucial intermediates in these processes. When RNA–DNA...
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Exploring TRF2-Dependent DNA Distortion Through Single-DNA Manipulation Studies
TRF2 is a component of shelterin, a telomere-specific protein complex that protects the ends of mammalian chromosomes from DNA damage signaling and...
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Genoty** Genome-Edited Founders and Subsequent Generation
Targeted nucleases allow the production of many types of genetic mutations directly in the early embryo. However, the outcome of their activity is a...
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High-throughput techniques enable advances in the roles of DNA and RNA secondary structures in transcriptional and post-transcriptional gene regulation
The most stable structure of DNA is the canonical right-handed double helix termed B DNA. However, certain environments and sequence motifs favor...
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Plastome sequencing of South American Podocarpus species reveals low rearrangement rates despite ancient gondwanan disjunctions
BackgroundHistorical reconstructions within Podocarpaceae have provided valuable information to disentangle biogeographic scenarios that begun 65...
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Genome-based characterization of the deep-sea psychrotolerant bacterium Bacillus altitudinis SORB11 isolated from the Indian Sector of the Southern Ocean
Life under deep-sea undergoes unusual adaption, especially with darkness, increased pressure, cold, and recalcitrant carbon. Microbes in the deep sea...
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Introduction to Epigenetics
Epigenetics is the study of inherited variations in gene expression that do not involve changes to DNA sequences. Over 200 unique cell types in a...
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Genomics
The field of genomics is interdisciplinary, and it is defined as the study of genes present in an organism along with the various techniques...
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An invasive Haemophilus influenzae serotype b infection in an Anglo-Saxon plague victim
BackgroundThe human pathogen Haemophilus influenzae was the main cause of bacterial meningitis in children and a major cause of worldwide infant...
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Diurnal cycles drive rhythmic physiology and promote survival in facultative phototrophic bacteria
Bacteria have evolved many strategies to spare energy when nutrients become scarce. One widespread such strategy is facultative phototrophy, which...
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RNase H1, the Gold Standard for R-Loop Detection
RNase H1 has become an essential tool to uncover the physiological and pathological roles of R-loops, three-stranded structures consisting of and...
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Disrupted architecture and fast evolution of the mitochondrial genome of Argeia pugettensis (Isopoda): implications for speciation and fitness
BackgroundArgeia pugettensis is an isopod species that parasitizes other crustaceans. Its huge native geographic range spans the Pacific from China...
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Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference
BackgroundDNA methylation is a key epigenetic modification in human development and disease, yet there is limited understanding of its highly...
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Strand asymmetry influences mismatch resolution during single-strand annealing
BackgroundBiases of DNA repair can shape the nucleotide landscape of genomes at evolutionary timescales. The molecular mechanisms of those biases are...
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The whole-genome sequencing in predicting Mycobacterium tuberculosis drug susceptibility and resistance in Papua, Indonesia
BackgroundTuberculosis is one of the deadliest disease caused by Mycobacterium tuberculosis . Its treatment still becomes a burden for many countries...
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Regulatory R-loops as facilitators of gene expression and genome stability
R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form during transcription. R-loop misregulation is associated...
