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Spinal Cord Injury and Assays for Regeneration
Due to their renowned regenerative capacity, adult zebrafish are a premier vertebrate model to interrogate mechanisms of innate spinal cord...
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Deubiquitinase UCHL1 promotes angiogenesis and blood–spinal cord barrier function recovery after spinal cord injury by stabilizing Sox17
Improving the function of the blood–spinal cord barrier (BSCB) benefits the functional recovery of mice following spinal cord injury (SCI). The death...
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FUNDC1-induced mitophagy protects spinal cord neurons against ischemic injury
Local ischemia and hypoxia are the most important pathological processes in the early phase of secondary spinal cord injury (SCI), in which...
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Effect of Spinal Cord Injury on P2 Signaling in the Cholinergic Synapse
AbstractThoracic spinal cord injuries are well known to entail the degradation of spinal motoneurons, accompanied by axonal degeneration. In the...
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The activation of dormant ependymal cells following spinal cord injury
Ependymal cells, a dormant population of ciliated progenitors found within the central canal of the spinal cord, undergo significant alterations...
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Role of peripheral immune cells in spinal cord injury
Secondary spinal cord injury is caused by an inflammatory response cascade, and the process is irreversible. The immune system, as a mediator of...
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Nicotinamide Riboside Promotes the Proliferation of Endogenous Neural Stem Cells to Repair Spinal Cord Injury
AbstractActivation of endogenous neural stem cells (NSC) is one of the most potential measures for neural repair after spinal cord injury. However,...
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Regulation of axonal regeneration after mammalian spinal cord injury
One hundred years ago, Ramón y Cajal, considered by many as the founder of modern neuroscience, stated that neurons of the adult central nervous...
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Conditioned medium-enriched umbilical cord mesenchymal stem cells: a potential therapeutic strategy for spinal cord injury, unveiling transcriptomic and secretomic insights
IntroductionSpinal cord injury (SCI) leads to significant destruction of nerve tissue, causing the degeneration of axons and the formation of cystic...
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Combined transplantation of hiPSC-NSC and hMSC ameliorated neuroinflammation and promoted neuroregeneration in acute spinal cord injury
BackgroundSpinal cord injury (SCI) is a serious clinical condition that has pathological changes such as increased neuroinflammation and nerve tissue...
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Electrical stimulation affects the differentiation of transplanted regionally specific human spinal neural progenitor cells (sNPCs) after chronic spinal cord injury
BackgroundThere are currently no effective clinical therapies to ameliorate the loss of function that occurs after spinal cord injury. Electrical...
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UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury
Activation of endogenous neural stem cells (NSCs) is greatly significant for the adult neurogenesis; however, it is extremely limited in the spinal...
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Exosome-mediated repair of spinal cord injury: a promising therapeutic strategy
Spinal cord injury (SCI) is a catastrophic injury to the central nervous system (CNS) that can lead to sensory and motor dysfunction, which seriously...
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Spinal cord injury dysregulates fibro-adipogenic progenitors miRNAs signaling to promote neurogenic heterotopic ossifications
Neurogenic heterotopic ossifications are intramuscular bone formations develo** following central nervous system injury. The pathophysiology is...
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Research progress and prospects of benefit-risk assessment methods for umbilical cord mesenchymal stem cell transplantation in the clinical treatment of spinal cord injury
Over the past decade, we have witnessed the development of cell transplantation as a new strategy for repairing spinal cord injury (SCI). However,...
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Modulation of Inflammatory Responses to Enhance Nerve Recovery after Spinal Cord Injury
Inflammation can occur at the wound site, and immune cells are necessary to trigger wound healing and tissue regeneration after injury. It is partly...
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The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury
Spinal cord injury (SCI) is a complex tissue injury that results in a wide range of physical deficits, including permanent or progressive...
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Controlling the Immune Response to Zebrafish Spinal Cord Injury via Extracellular Vesicles Secreted by Activated Monocyte-like Cells
AbstractThe immune response to spinal cord injury (SCI) is implemented via local and systemic inflammation, followed by repair and...
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Developmental stage of transplanted neural progenitor cells influences anatomical and functional outcomes after spinal cord injury in mice
Neural progenitor cell (NPC) transplantation is a promising therapeutic strategy for replacing lost neurons following spinal cord injury (SCI)....
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Protocol paper: kainic acid excitotoxicity-induced spinal cord injury paraplegia in Sprague–Dawley rats
BackgroundExcitotoxicity-induced in vivo injury models are vital to reflect the pathophysiological features of acute spinal cord injury (SCI) in...
